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- W3131454261 endingPage "551" @default.
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- W3131454261 abstract "The irinotecan-loaded double-reverse thermosensitive hydrogel (DRTH) is a dispersed system of irinotecan-loaded solid lipid nanoparticles (SLN) in a thermosensitive hydrogel. To optimise the particle and gel properties of DRTHs for rectal administration of irinotecan, SLNs and DRTHs were prepared with tricaprin, triethanolamine, Tween 80, and Span 20. Among the SLNs tested, an SLN composed of 1 g irinotecan, 0.5 g lipid mixture, and 0.5 g combined surfactant gave the highest entrapment efficiency and smallest particle size. A DRTH composed of (poloxamer 407/poloxamer 188/combined surfactant/SLN dispersion/H2O (10/15/17/4/54%)) showed easy administration, fast gelling, and strong gel-forming in the body." @default.
- W3131454261 created "2021-03-01" @default.
- W3131454261 creator A5034418015 @default.
- W3131454261 creator A5040128343 @default.
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- W3131454261 date "2021-02-13" @default.
- W3131454261 modified "2023-10-18" @default.
- W3131454261 title "Particle and Gel Characterization of Irinotecan-Loaded Double-Reverse Thermosensitive Hydrogel" @default.
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- W3131454261 doi "https://doi.org/10.3390/polym13040551" @default.
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- W3131454261 hasPublicationYear "2021" @default.
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