Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131479438> ?p ?o ?g. }
- W3131479438 endingPage "435" @default.
- W3131479438 startingPage "427" @default.
- W3131479438 abstract "A structurally defined konjac glucomannan oligosaccharide (KGMOS) with a relatively high molecular weight and narrow molecular weight distribution (molecular weight ranging from 3000 to 4000 Da, degree of polymerization (dp) 8–11) was prepared from native konjac glucomannan (KGM), and the beneficial effects and molecular mechanisms of KGMOS on colonic functions were investigated in C57BL/6 mice. The results are the first to reveal that KGMOS regulated intestinal microflora composition to facilitate the production of colonic butyrate. Elevated butyrate production further increased the acetylation of histone proteins H3 and H4 and thus enhanced the transcription of the major colonic mucin gene Muc2 and the secretion of mucin elements, which represents a new molecular mechanism of KGM oligosaccharide consumption. The findings indicate that KGM oligosaccharides with specific molecular sizes have highly desirable functional properties and potentially could improve gut health by promoting the barrier function of the colonic mucosa." @default.
- W3131479438 created "2021-03-01" @default.
- W3131479438 creator A5051064175 @default.
- W3131479438 creator A5077139370 @default.
- W3131479438 creator A5078995006 @default.
- W3131479438 creator A5080944719 @default.
- W3131479438 creator A5085815447 @default.
- W3131479438 date "2021-02-15" @default.
- W3131479438 modified "2023-10-17" @default.
- W3131479438 title "A Purified Glucomannan Oligosaccharide from <i>Amorphophallus konjac</i> Improves Colonic Mucosal Barrier Function via Enhancing Butyrate Production and Histone Protein H3 and H4 Acetylation" @default.
- W3131479438 cites W1793535310 @default.
- W3131479438 cites W1965985248 @default.
- W3131479438 cites W1974477809 @default.
- W3131479438 cites W1977726627 @default.
- W3131479438 cites W1988821718 @default.
- W3131479438 cites W2001374011 @default.
- W3131479438 cites W2002703043 @default.
- W3131479438 cites W2046349950 @default.
- W3131479438 cites W2050920580 @default.
- W3131479438 cites W2076386438 @default.
- W3131479438 cites W2086216523 @default.
- W3131479438 cites W2092354724 @default.
- W3131479438 cites W2114277486 @default.
- W3131479438 cites W2133856765 @default.
- W3131479438 cites W2136633470 @default.
- W3131479438 cites W2163229571 @default.
- W3131479438 cites W2169330513 @default.
- W3131479438 cites W2184135312 @default.
- W3131479438 cites W2200002105 @default.
- W3131479438 cites W2314548403 @default.
- W3131479438 cites W2478229596 @default.
- W3131479438 cites W2525398874 @default.
- W3131479438 cites W2550084345 @default.
- W3131479438 cites W2557717486 @default.
- W3131479438 cites W2588083087 @default.
- W3131479438 cites W2800579225 @default.
- W3131479438 cites W2816202300 @default.
- W3131479438 cites W2892205465 @default.
- W3131479438 cites W2900192196 @default.
- W3131479438 cites W2911943333 @default.
- W3131479438 cites W2917904707 @default.
- W3131479438 cites W2937564598 @default.
- W3131479438 cites W2966039191 @default.
- W3131479438 cites W2978573041 @default.
- W3131479438 cites W2984389064 @default.
- W3131479438 cites W3000859460 @default.
- W3131479438 cites W3025192260 @default.
- W3131479438 cites W3027118763 @default.
- W3131479438 cites W4233585647 @default.
- W3131479438 doi "https://doi.org/10.1021/acs.jnatprod.0c01125" @default.
- W3131479438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33587639" @default.
- W3131479438 hasPublicationYear "2021" @default.
- W3131479438 type Work @default.
- W3131479438 sameAs 3131479438 @default.
- W3131479438 citedByCount "5" @default.
- W3131479438 countsByYear W31314794382021 @default.
- W3131479438 countsByYear W31314794382022 @default.
- W3131479438 countsByYear W31314794382023 @default.
- W3131479438 crossrefType "journal-article" @default.
- W3131479438 hasAuthorship W3131479438A5051064175 @default.
- W3131479438 hasAuthorship W3131479438A5077139370 @default.
- W3131479438 hasAuthorship W3131479438A5078995006 @default.
- W3131479438 hasAuthorship W3131479438A5080944719 @default.
- W3131479438 hasAuthorship W3131479438A5085815447 @default.
- W3131479438 hasConcept C100544194 @default.
- W3131479438 hasConcept C104317684 @default.
- W3131479438 hasConcept C119157956 @default.
- W3131479438 hasConcept C179264091 @default.
- W3131479438 hasConcept C185592680 @default.
- W3131479438 hasConcept C2776979534 @default.
- W3131479438 hasConcept C2777726330 @default.
- W3131479438 hasConcept C2780179618 @default.
- W3131479438 hasConcept C55493867 @default.
- W3131479438 hasConcept C64927066 @default.
- W3131479438 hasConceptScore W3131479438C100544194 @default.
- W3131479438 hasConceptScore W3131479438C104317684 @default.
- W3131479438 hasConceptScore W3131479438C119157956 @default.
- W3131479438 hasConceptScore W3131479438C179264091 @default.
- W3131479438 hasConceptScore W3131479438C185592680 @default.
- W3131479438 hasConceptScore W3131479438C2776979534 @default.
- W3131479438 hasConceptScore W3131479438C2777726330 @default.
- W3131479438 hasConceptScore W3131479438C2780179618 @default.
- W3131479438 hasConceptScore W3131479438C55493867 @default.
- W3131479438 hasConceptScore W3131479438C64927066 @default.
- W3131479438 hasFunder F4320321001 @default.
- W3131479438 hasFunder F4320322665 @default.
- W3131479438 hasIssue "2" @default.
- W3131479438 hasLocation W31314794381 @default.
- W3131479438 hasOpenAccess W3131479438 @default.
- W3131479438 hasPrimaryLocation W31314794381 @default.
- W3131479438 hasRelatedWork W162737621 @default.
- W3131479438 hasRelatedWork W1988871235 @default.
- W3131479438 hasRelatedWork W2004118219 @default.
- W3131479438 hasRelatedWork W2025964357 @default.
- W3131479438 hasRelatedWork W2107270084 @default.
- W3131479438 hasRelatedWork W2122841964 @default.
- W3131479438 hasRelatedWork W3000851497 @default.
- W3131479438 hasRelatedWork W3131479438 @default.