Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131484568> ?p ?o ?g. }
- W3131484568 endingPage "328" @default.
- W3131484568 startingPage "328" @default.
- W3131484568 abstract "Oxidative stress is one of the main causes of brain cell death in neurological disorders. The use of natural antioxidants to maintain redox homeostasis contributes to alleviating neurodegeneration. Glutamate is an excitatory neurotransmitter that plays a critical role in many brain functions. However, excessive glutamate release induces excitotoxicity and oxidative stress, leading to programmed cell death. Our study aimed to evaluate the effect of osmundacetone (OAC), isolated from Elsholtzia ciliata (Thunb.) Hylander, against glutamate-induced oxidative toxicity in HT22 hippocampal cells. The effect of OAC treatment on excess reactive oxygen species (ROS), intracellular calcium levels, chromatin condensation, apoptosis, and the expression level of oxidative stress-related proteins was evaluated. OAC showed a neuroprotective effect against glutamate toxicity at a concentration of 2 μM. By diminishing the accumulation of ROS, as well as stimulating the expression of heat shock protein 70 (HSP70) and heme oxygenase-1 (HO-1), OAC triggered the self-defense mechanism in neuronal cells. The anti-apoptotic effect of OAC was demonstrated through its inhibition of chromatin condensation, calcium accumulation, and reduction of apoptotic cells. OAC significantly suppressed the phosphorylation of mitogen-activated protein kinases (MAPKs), including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 kinases. Thus, OAC could be a potential agent for supportive treatment of neurodegenerative diseases." @default.
- W3131484568 created "2021-03-01" @default.
- W3131484568 creator A5013351576 @default.
- W3131484568 creator A5034078083 @default.
- W3131484568 creator A5072186443 @default.
- W3131484568 creator A5090156025 @default.
- W3131484568 creator A5090681630 @default.
- W3131484568 date "2021-02-22" @default.
- W3131484568 modified "2023-10-09" @default.
- W3131484568 title "Protective Effect of Osmundacetone against Neurological Cell Death Caused by Oxidative Glutamate Toxicity" @default.
- W3131484568 cites W1032629512 @default.
- W3131484568 cites W133186721 @default.
- W3131484568 cites W1495220312 @default.
- W3131484568 cites W1933803332 @default.
- W3131484568 cites W1963844828 @default.
- W3131484568 cites W1966169165 @default.
- W3131484568 cites W1979089280 @default.
- W3131484568 cites W1991413218 @default.
- W3131484568 cites W1999055613 @default.
- W3131484568 cites W2016575029 @default.
- W3131484568 cites W2024765816 @default.
- W3131484568 cites W2036264982 @default.
- W3131484568 cites W2044708797 @default.
- W3131484568 cites W2044971638 @default.
- W3131484568 cites W2049822863 @default.
- W3131484568 cites W2051344987 @default.
- W3131484568 cites W2053486814 @default.
- W3131484568 cites W2053630894 @default.
- W3131484568 cites W2054683291 @default.
- W3131484568 cites W2057495929 @default.
- W3131484568 cites W2060630008 @default.
- W3131484568 cites W2066768357 @default.
- W3131484568 cites W2070497389 @default.
- W3131484568 cites W2082879602 @default.
- W3131484568 cites W2097744068 @default.
- W3131484568 cites W2114282533 @default.
- W3131484568 cites W2114576740 @default.
- W3131484568 cites W2147034321 @default.
- W3131484568 cites W2147993424 @default.
- W3131484568 cites W2150266267 @default.
- W3131484568 cites W2156246932 @default.
- W3131484568 cites W2252909698 @default.
- W3131484568 cites W2340338776 @default.
- W3131484568 cites W2418076494 @default.
- W3131484568 cites W2612801017 @default.
- W3131484568 cites W2678510013 @default.
- W3131484568 cites W2697719093 @default.
- W3131484568 cites W2731248427 @default.
- W3131484568 cites W2773261440 @default.
- W3131484568 cites W2897537084 @default.
- W3131484568 cites W2904968162 @default.
- W3131484568 cites W2911226018 @default.
- W3131484568 cites W2937074474 @default.
- W3131484568 cites W3010258615 @default.
- W3131484568 cites W4292752127 @default.
- W3131484568 cites W69095940 @default.
- W3131484568 doi "https://doi.org/10.3390/biom11020328" @default.
- W3131484568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7926874" @default.
- W3131484568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33671577" @default.
- W3131484568 hasPublicationYear "2021" @default.
- W3131484568 type Work @default.
- W3131484568 sameAs 3131484568 @default.
- W3131484568 citedByCount "9" @default.
- W3131484568 countsByYear W31314845682021 @default.
- W3131484568 countsByYear W31314845682022 @default.
- W3131484568 countsByYear W31314845682023 @default.
- W3131484568 crossrefType "journal-article" @default.
- W3131484568 hasAuthorship W3131484568A5013351576 @default.
- W3131484568 hasAuthorship W3131484568A5034078083 @default.
- W3131484568 hasAuthorship W3131484568A5072186443 @default.
- W3131484568 hasAuthorship W3131484568A5090156025 @default.
- W3131484568 hasAuthorship W3131484568A5090681630 @default.
- W3131484568 hasBestOaLocation W31314845681 @default.
- W3131484568 hasConcept C126322002 @default.
- W3131484568 hasConcept C170493617 @default.
- W3131484568 hasConcept C184235292 @default.
- W3131484568 hasConcept C185592680 @default.
- W3131484568 hasConcept C190283241 @default.
- W3131484568 hasConcept C25498285 @default.
- W3131484568 hasConcept C2776151105 @default.
- W3131484568 hasConcept C2776925932 @default.
- W3131484568 hasConcept C2779134260 @default.
- W3131484568 hasConcept C2781012912 @default.
- W3131484568 hasConcept C31573885 @default.
- W3131484568 hasConcept C48349386 @default.
- W3131484568 hasConcept C51551487 @default.
- W3131484568 hasConcept C55493867 @default.
- W3131484568 hasConcept C57074206 @default.
- W3131484568 hasConcept C61174792 @default.
- W3131484568 hasConcept C71924100 @default.
- W3131484568 hasConcept C86803240 @default.
- W3131484568 hasConcept C95444343 @default.
- W3131484568 hasConcept C98274493 @default.
- W3131484568 hasConceptScore W3131484568C126322002 @default.
- W3131484568 hasConceptScore W3131484568C170493617 @default.
- W3131484568 hasConceptScore W3131484568C184235292 @default.
- W3131484568 hasConceptScore W3131484568C185592680 @default.
- W3131484568 hasConceptScore W3131484568C190283241 @default.