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• W3131486283 abstract "Introduction Global progress in reducing malaria has stalled since 2015. Analysis of the situation is particularly needed in Nigeria, the country with by far the largest share of the burden, where approximately a quarter of all cases in the world are estimated to occur. Methods We analysed data from three nationwide surveys (Malaria Indicator Surveys in 2010 and 2015 and a National Demographic and Health Survey in 2018), with malaria parasite prevalence in children under 5 years of age determined by sampling from all 36 states of Nigeria, and blood slide microscopy performed in the same accredited laboratory for all samples. Changes over time were evaluated by calculating prevalence ratio (PR) values with 95% CIs for each state, together with Mantel-Haenszel-adjusted PRs (PR adj ) for each of the six major geopolitical zones of the country. Results Between 2010 and 2018, there were significant reductions in parasite prevalence in 25 states, but not in the remaining 11 states. Prevalence decreased most in southern zones of the country (South West PR adj =0.53; South East PR adj =0.59; South South PR adj =0.51) and the North Central zone (PR adj =0.36). Changes in the north were less marked, but were significant and indicated overall reductions by more than 20% (North-West PR adj =0.74; North East PR adj =0.70). Changes in the south occurred mostly between 2010 and 2015, whereas those in the north were more gradual and most continued after 2015. Recent changes were not correlated with survey-reported variation in use of preventive measures. Conclusion Reductions in malaria infection in children under 5 have occurred in most individual states in Nigeria since 2010, but substantial geographical variation in the timing and extent indicate challenges to be overcome to enable global malaria reduction." @default.
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• W3131486283 date "2021-02-01" @default.
• W3131486283 modified "2023-09-26" @default.
• W3131486283 title "Geographical and temporal variation in reduction of malaria infection among children under 5 years of age throughout Nigeria" @default.
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• W3131486283 doi "https://doi.org/10.1136/bmjgh-2020-004250" @default.
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