FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131488837> ?p ?o ?g. }

• W3131488837 abstract "Abstract Introduction The first 1000 days of life could contribute to individual susceptibility to the later development of chronic non-communicable diseases. Nutrition in early life appears to be an important determinant factor for a sustainable child’s health. In this study, we propose to investigate the impact of exclusive breastfeeding on gut health in children. Methods and analysis A prospective cohort of newborns (n=350) will be recruited at birth and followed up to 4 years of age. The main objective is to evaluate the link between exclusive breastfeeding for at least 3 months and the gut health of the child at 4 years. The primary endpoint of assessment of gut health will be based on the non-invasive measurement of fecal secretory immunoglobulin A (sIgA) as a sensitive biomarker of the intestinal ecosystem. The presence of gastrointestinal disorders will be defined according to the clinical criteria of ROME IV. Information on parent’s nutritional habits and life style, breastfeeding duration and child’s complementary feeding will be collected along the follow-up. Cord blood cells and plasma at birth will be purified for further analysis. The meconium and stools collected at birth, 6 months, 2 years and 4 years of age will allow sIgA analysis. Ethics and dissemination This clinical study has obtained the approval from the national ethical committee. We plan to publish the results of the study in peer-review journals and by means of national and international conference. Trial registration number NCT04195425 Strengths and limitations of the study - This is a prospective and longitudinal mother/child cohort with minimal constraints (3 visits over 4 years) and minimal risk (no intervention and minimally invasive procedures). - The study will collect a great deal of longitudinal information on children during the first years of life, their parents and their environment via questionnaires and biological samples (cord blood, meconium, stools). - This study will obtain precise data on breastfeeding practices and their short- and medium-term effects on the health of the child, in particular and in an innovative way on gut health through stool samples for immunological analysis, and by using the ROME IV paediatric questionnaire. - Weaknesses could be relied to confounding factors at the selection process and during the follow-up. - Due to the non-interventional study design we will be able to study association but no causal relationship. - The nutritional survey during the study is primarily based on reports from parents and is retrospective which could contribute to inaccuracies due to long delay between each visit." @default.
• W3131488837 created "2021-03-01" @default.
• W3131488837 creator A5013990412 @default.
• W3131488837 creator A5016677949 @default.
• W3131488837 creator A5023851321 @default.
• W3131488837 creator A5031872603 @default.
• W3131488837 creator A5034643275 @default.
• W3131488837 creator A5039664930 @default.
• W3131488837 creator A5041737432 @default.
• W3131488837 creator A5048527762 @default.
• W3131488837 creator A5054090085 @default.
• W3131488837 creator A5081460836 @default.
• W3131488837 date "2021-02-23" @default.
• W3131488837 modified "2023-10-03" @default.
• W3131488837 title "Impact of early life nutrition on gut health in children: A prospective clinical study" @default.
• W3131488837 cites W1745675679 @default.
• W3131488837 cites W1976335360 @default.
• W3131488837 cites W1990379298 @default.
• W3131488837 cites W1992052312 @default.
• W3131488837 cites W2040244187 @default.
• W3131488837 cites W2058571502 @default.
• W3131488837 cites W2061478557 @default.
• W3131488837 cites W2079973462 @default.
• W3131488837 cites W2086224292 @default.
• W3131488837 cites W2090538642 @default.
• W3131488837 cites W2115098571 @default.
• W3131488837 cites W2118502261 @default.
• W3131488837 cites W2137457675 @default.
• W3131488837 cites W2148195572 @default.
• W3131488837 cites W2267159071 @default.
• W3131488837 cites W2287199420 @default.
• W3131488837 cites W2350379238 @default.
• W3131488837 cites W2604393173 @default.
• W3131488837 cites W2746545692 @default.
• W3131488837 cites W2767360135 @default.
• W3131488837 cites W2785246265 @default.
• W3131488837 cites W2799953554 @default.
• W3131488837 cites W2990164947 @default.
• W3131488837 cites W3022248945 @default.
• W3131488837 cites W3045283100 @default.
• W3131488837 doi "https://doi.org/10.1101/2021.02.19.21252039" @default.
• W3131488837 hasPublicationYear "2021" @default.
• W3131488837 type Work @default.
• W3131488837 sameAs 3131488837 @default.
• W3131488837 citedByCount "0" @default.
• W3131488837 crossrefType "posted-content" @default.
• W3131488837 hasAuthorship W3131488837A5013990412 @default.
• W3131488837 hasAuthorship W3131488837A5016677949 @default.
• W3131488837 hasAuthorship W3131488837A5023851321 @default.
• W3131488837 hasAuthorship W3131488837A5031872603 @default.
• W3131488837 hasAuthorship W3131488837A5034643275 @default.
• W3131488837 hasAuthorship W3131488837A5039664930 @default.
• W3131488837 hasAuthorship W3131488837A5041737432 @default.
• W3131488837 hasAuthorship W3131488837A5048527762 @default.
• W3131488837 hasAuthorship W3131488837A5054090085 @default.
• W3131488837 hasAuthorship W3131488837A5081460836 @default.
• W3131488837 hasBestOaLocation W31314888371 @default.
• W3131488837 hasConcept C126322002 @default.
• W3131488837 hasConcept C187212893 @default.
• W3131488837 hasConcept C188816634 @default.
• W3131488837 hasConcept C2776283161 @default.
• W3131488837 hasConcept C512399662 @default.
• W3131488837 hasConcept C71924100 @default.
• W3131488837 hasConceptScore W3131488837C126322002 @default.
• W3131488837 hasConceptScore W3131488837C187212893 @default.
• W3131488837 hasConceptScore W3131488837C188816634 @default.
• W3131488837 hasConceptScore W3131488837C2776283161 @default.
• W3131488837 hasConceptScore W3131488837C512399662 @default.
• W3131488837 hasConceptScore W3131488837C71924100 @default.
• W3131488837 hasLocation W31314888371 @default.
• W3131488837 hasLocation W31314888372 @default.
• W3131488837 hasLocation W31314888373 @default.
• W3131488837 hasLocation W31314888374 @default.
• W3131488837 hasOpenAccess W3131488837 @default.
• W3131488837 hasPrimaryLocation W31314888371 @default.
• W3131488837 hasRelatedWork W1698251213 @default.
• W3131488837 hasRelatedWork W2039947885 @default.
• W3131488837 hasRelatedWork W2041963815 @default.
• W3131488837 hasRelatedWork W2138459844 @default.
• W3131488837 hasRelatedWork W2295722933 @default.
• W3131488837 hasRelatedWork W2799473411 @default.
• W3131488837 hasRelatedWork W2980657228 @default.
• W3131488837 hasRelatedWork W4283585209 @default.
• W3131488837 hasRelatedWork W4291618142 @default.
• W3131488837 hasRelatedWork W4298204368 @default.
• W3131488837 isParatext "false" @default.
• W3131488837 isRetracted "false" @default.
• W3131488837 magId "3131488837" @default.
• W3131488837 workType "article" @default.