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- W313149855 abstract "The divalent cation calcium Ca2+ is an almost universal intracellular messenger. Ca2+ is used by cells to control a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation. There are a number of different fluorescence microscopy techniques, which allow the visualization of intracellular changes of this ion. Time course confocal microscopy is helping to provide a spatial and temporal insight into the signalling mechanisms which control morphological and functional cellular changes in living cells. We are studying the nature of the non-genomic effects of steroids on human endometrial cells using physiological and anatomical methods. These studies are providing an insight into the dialogue between the epithelial and stromal compartments of this dynamic tissue. They are also providing clues as to the molecular/signalling mechanisms that underlie the ability of the endometrium to accept or reject a blastocyst. These mechanisms are fundamental to reproduction but similar mechanisms are common to all embryonic epithelial/mesenchymal interactions. The analysis of dynamic confocal data sets poses significant data analysis challenges. A large part of this complexity derives from the necessity to simultaneously consider both spatial and temporal components of variation. Adaptations of various multivariate analysis methods including clustering, factor analysis, principal components and mixture modelling are of considerable practical interest. This presentation is concerned with mixture analysis. In mixture analysis pixel-level time course data are approximated as a weighted linear combination of a number of dominant time-course characteristics represented in the data. The analysis has the effect of separating spatial and temporal variation which can facilitate local metabolic analysis. This methodology was originally developed for application to PET and MRI studies, however, it also seems to allow an objective spatial and temporal resolution of intracellular calcium dynamics." @default.
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- W313149855 date "2004-12-01" @default.
- W313149855 modified "2023-09-23" @default.
- W313149855 title "P35: Locally constrained mixture representation of dynamic imaging data of calcium fluctuations obtained from dynamic confocal microscopy studies" @default.
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