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• W3131579362 abstract "Abstract Background & Aims Late recurrence of hepatocellular carcinoma (HCC) is regarded as de novo HCC from chronic hepatitis. This study investigated clinicopathological and molecular factors to develop a nomogram for predicting late HCC recurrence (>2 years after curative resection). Methods The training and validation cohorts included HCC patients with a major aetiology of hepatitis B who underwent curative resection. Clinicopathological features including lobular and porto‐periportal inflammatory activity, fibrosis and liver cell change were evaluated. Proteins encoded by genes related to late recurrence were identified using a reverse phase protein array of 95 non‐tumourous liver tissues. Immunoexpression of phosphorylated signal transducer and activator of transcription 3 (pSTAT3), plasminogen activator inhibitor‐1, phosphorylated extracellular signal‐regulated kinase 1/2 (pERK1/2) and spleen tyrosine kinase (SYK) was measured. Results Late recurrence occurred in 74/402 (18%) and 47/243 (19%) in the training and validation cohorts respectively. Cirrhosis, moderate/severe lobular inflammatory activity, and expression of pSTAT3, pERK1/2, and SYK proteins correlated to the gene signature of hepatocyte injury and regeneration were independently associated with late recurrence, with odds ratios (95% confidence intervals) of 2.0 (1.2‐3.3), 21.1 (4.3‐102.7) and 6.0 (2.1‐17.7) respectively ( P < .05 for all). A nomogram based on these variables (histological parameters and immunohistochemical marker combinations) showed high reliability in both the training and validation cohorts (Harrell’s C index: 0.701 and 0.716; 95% confidence intervals: 0.64‐0.76 and 0.64‐0.79 respectively). Conclusions The combination of pSTAT3, pERK1/2 and SYK immunoexpression with high lobular inflammatory activity and cirrhosis (fibrosis) predicts late HCC recurrence." @default.
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• W3131579362 date "2021-03-25" @default.
• W3131579362 modified "2023-10-17" @default.
• W3131579362 title "Pathological predictive factors for late recurrence of hepatocellular carcinoma in chronic liver disease" @default.
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• W3131579362 doi "https://doi.org/10.1111/liv.14835" @default.
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