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- W3131591698 abstract "FOXC1, a transcription factor involved in cell differentiation and embryogenesis, is demonstrated to be a negative regulator of Nanog in this study. FOXC1 is up-regulated in retinoic acid-induced differentiation of F9 Embryonal Carcinoma (EC) cells; furthermore, FOXC1 specifically inhibits the core pluripotency factor Nanog by binding to the proximal promoter. Overexpression of FOXC1 in F9 or knockdown in 3T3 results in the down-regulation or up-regulation of Nanog mRNA and proteins, respectively. In order to explain the mechanism by which FOXC1 inhibits Nanog expression, we identified the co-repressor HDAC2 from the FOXC1 interactome. FOXC1 recruits HDAC2 to Nanog promoter to decrease H3K27ac enrichment, resulting in transcription inhibition of Nanog. To the best of our knowledge, this is the first report that FOXC1 is involved in the epigenetic regulation of gene expression." @default.
- W3131591698 created "2021-03-01" @default.
- W3131591698 creator A5022812446 @default.
- W3131591698 creator A5030619489 @default.
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- W3131591698 creator A5062121324 @default.
- W3131591698 creator A5066532917 @default.
- W3131591698 creator A5066843850 @default.
- W3131591698 date "2021-02-24" @default.
- W3131591698 modified "2023-10-18" @default.
- W3131591698 title "FOXC1 Downregulates Nanog Expression by Recruiting HDAC2 to Its Promoter in F9 Cells Treated by Retinoic Acid" @default.
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