Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131620481> ?p ?o ?g. }
- W3131620481 abstract "Significance T cells recognize their targets via their T-cell receptors (TCRs), which in the case of CD8 + T cells bind to MHC-I:antigen complexes on the surface of target cells. Many cancer cells evade immune recognition and killing by down-regulating MHC-I AgPPM. Here, we show how the histone acetyl transferases p300/CBP together with NF-κB epigenetically regulate expression of MHC-I molecules, immunoproteasome subunits, and peptide transporter to enable proper MHC-I antigen presentation. Notably, this pathway is frequently disrupted in human cancers. We now show that certain chemotherapeutics can augment MHC-I antigen presentation via NF-κB and p300/CBP activation, thereby enhancing cancer cell recognition and killing by effector CD8 + CTLs." @default.
- W3131620481 created "2021-03-01" @default.
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- W3131620481 date "2021-02-18" @default.
- W3131620481 modified "2023-10-14" @default.
- W3131620481 title "Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation" @default.
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