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• W3131650725 abstract "Tumor-infiltrating lymphocytes (TILs) have important roles in predicting tumor therapeutic responses and progression, however, the method of evaluating TILs is complicated. We attempted to explore the association of TILs with clinicopathological characteristics and blood indicators, and to develop nomograms to predict the density of TILs in patients with high-grade serous ovarian cancer (HGSOC).The clinical profiles of 197 consecutive postoperative HGSOC patients were retrospectively analyzed. Tumor tissues and matched normal fallopian tubes were immunostained for CD3+, CD8+, and CD4+ T cells on corresponding tissue microarrays and the numbers of TILs were counted using the NIH ImageJ software. The patients were classified into low- or high-density groups for each marker (CD3, CD4, CD8). The associations of the investigated TILs to clinicopathological characteristics and blood indicators were assessed and the related predictors for densities of TILs were used to develop nomograms; which were then further evaluated using the C-index, receiver operating characteristic (ROC) curves and calibration plots.Menopausal status, estrogen receptor (ER), Ki-67 index, white blood cell (WBC), platelets (PLT), lactate dehydrogenase (LDH), and carbohydrate antigen 153 (CA153) had significant association with densities of tumor-infiltrating CD3+, CD8+, or CD4+ T cells. The calibration curves of the CD3+ (C-index = 0.748), CD8+ (C-index = 0.683) and CD4+ TILs nomogram (C-index = 0.759) demonstrated excellent agreement between predictions and actual observations. ROC curves of internal validation indicated good discrimination for the CD8+ TILs nomogram [area under the curve (AUC) = 0.659, 95% CI 0.582-0.736] and encouraging performance for the CD3+ (AUC= 0.708, 95% CI 0.636-0.781) and CD4+ TILs nomogram (AUC = 0.730, 95% CI 0.659-0.801).Menopausal status, ER, Ki-67 index, WBC, PLT, LDH, and CA153 could reflect the densities of T cells in the tumor microenvironment. Novel nomograms are conducive to monitor the immune status of patients with HGSOC and help doctors to formulate the appropriate treatment strategies." @default.
• W3131650725 created "2021-03-01" @default.
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• W3131650725 date "2021-02-25" @default.
• W3131650725 modified "2023-10-13" @default.
• W3131650725 title "Nomograms to Predict the Density of Tumor-Infiltrating Lymphocytes in Patients With High-Grade Serous Ovarian Cancer" @default.
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• W3131650725 cites W1972506570 @default.
• W3131650725 cites W1991941102 @default.
• W3131650725 cites W1996145004 @default.
• W3131650725 cites W2005936795 @default.
• W3131650725 cites W2006983673 @default.
• W3131650725 cites W2007463346 @default.
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• W3131650725 cites W2021202339 @default.
• W3131650725 cites W2027646895 @default.
• W3131650725 cites W2027726380 @default.
• W3131650725 cites W2033707203 @default.
• W3131650725 cites W2036159305 @default.
• W3131650725 cites W2038152856 @default.
• W3131650725 cites W2055727380 @default.
• W3131650725 cites W2065079849 @default.
• W3131650725 cites W2071181338 @default.
• W3131650725 cites W2075295437 @default.
• W3131650725 cites W2078492832 @default.
• W3131650725 cites W2081177143 @default.
• W3131650725 cites W2090491560 @default.
• W3131650725 cites W2102004732 @default.
• W3131650725 cites W2105459360 @default.
• W3131650725 cites W2106010518 @default.
• W3131650725 cites W2111900617 @default.
• W3131650725 cites W2116906103 @default.
• W3131650725 cites W2117087685 @default.
• W3131650725 cites W2117600467 @default.
• W3131650725 cites W2120431466 @default.
• W3131650725 cites W2127387778 @default.
• W3131650725 cites W2127999139 @default.
• W3131650725 cites W2130310310 @default.
• W3131650725 cites W2136849848 @default.
• W3131650725 cites W2138644182 @default.
• W3131650725 cites W2145360445 @default.
• W3131650725 cites W2153505392 @default.
• W3131650725 cites W2208365536 @default.
• W3131650725 cites W2208367991 @default.
• W3131650725 cites W2329342162 @default.
• W3131650725 cites W2407719071 @default.
• W3131650725 cites W2498119267 @default.
• W3131650725 cites W2506186937 @default.
• W3131650725 cites W2514623274 @default.
• W3131650725 cites W2515679040 @default.
• W3131650725 cites W2519020116 @default.
• W3131650725 cites W2538171015 @default.
• W3131650725 cites W2561042881 @default.
• W3131650725 cites W2611950171 @default.
• W3131650725 cites W2735971721 @default.
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• W3131650725 doi "https://doi.org/10.3389/fonc.2021.590414" @default.
• W3131650725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7946970" @default.
• W3131650725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33718143" @default.
• W3131650725 hasPublicationYear "2021" @default.
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