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- W3131650987 endingPage "632" @default.
- W3131650987 startingPage "616" @default.
- W3131650987 abstract "Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of upper and lower motor neurons with high burden on society. Despite tremendous efforts over the last several decades, there is still no definite cure for ALS. Up to now, only two disease-modifying agents, riluzole and edaravone, are approved by U.S. Food and Drug Administration (FDA) for ALS treatment, which only modestly improves survival and disease progression. Major challenging issues to find an effective therapy are heterogeneity in the pathogenesis and genetic variability of ALS. As such, stem cell therapy has been recently a focus of both preclinical and clinical investigations of ALS. This is because stem cells have multifaceted features that can potentially target multiple pathogenic mechanisms in ALS even though its underlying mechanisms are not completely elucidated. Methods & Results: Here, we will have an overview of stem cell therapy in ALS, including their therapeutic mechanisms, the results of recent clinical trials as well as ongoing clinical trials. In addition, we will further discuss complications and limitations of stem cell therapy in ALS. Conclusion: The determination of whether stem cells offer a viable treatment strategy for ALS rests on well-designed and appropriately powered future clinical trials. Randomized, double-blinded, and sham-controlled studies would be valuable." @default.
- W3131650987 created "2021-03-01" @default.
- W3131650987 creator A5002639429 @default.
- W3131650987 creator A5051922970 @default.
- W3131650987 creator A5091578932 @default.
- W3131650987 date "2021-02-25" @default.
- W3131650987 modified "2023-09-30" @default.
- W3131650987 title "Overview of stem cells therapy in amyotrophic lateral sclerosis" @default.
- W3131650987 cites W1493382393 @default.
- W3131650987 cites W1503916499 @default.
- W3131650987 cites W1564282316 @default.
- W3131650987 cites W1680874712 @default.
- W3131650987 cites W1690963752 @default.
- W3131650987 cites W1785382835 @default.
- W3131650987 cites W1947857796 @default.
- W3131650987 cites W1963646113 @default.
- W3131650987 cites W1965265324 @default.
- W3131650987 cites W1972681625 @default.
- W3131650987 cites W1977791285 @default.
- W3131650987 cites W1986643185 @default.
- W3131650987 cites W1989464571 @default.
- W3131650987 cites W1990565287 @default.
- W3131650987 cites W2012663773 @default.
- W3131650987 cites W2014258285 @default.
- W3131650987 cites W2016879629 @default.
- W3131650987 cites W2022009847 @default.
- W3131650987 cites W2023509574 @default.
- W3131650987 cites W2026406888 @default.
- W3131650987 cites W2032269048 @default.
- W3131650987 cites W2040773899 @default.
- W3131650987 cites W2042305406 @default.
- W3131650987 cites W2045574035 @default.
- W3131650987 cites W2045655578 @default.
- W3131650987 cites W2047266355 @default.
- W3131650987 cites W2052332287 @default.
- W3131650987 cites W2058851462 @default.
- W3131650987 cites W2065566057 @default.
- W3131650987 cites W2077861515 @default.
- W3131650987 cites W2077962324 @default.
- W3131650987 cites W2078904608 @default.
- W3131650987 cites W2079691345 @default.
- W3131650987 cites W2080474239 @default.
- W3131650987 cites W2086332063 @default.
- W3131650987 cites W2089502182 @default.
- W3131650987 cites W2092390300 @default.
- W3131650987 cites W2092580783 @default.
- W3131650987 cites W2103824500 @default.
- W3131650987 cites W2111199774 @default.
- W3131650987 cites W2119665388 @default.
- W3131650987 cites W2121500739 @default.
- W3131650987 cites W2121589895 @default.
- W3131650987 cites W2123402756 @default.
- W3131650987 cites W2125987139 @default.
- W3131650987 cites W2128061107 @default.
- W3131650987 cites W2128203287 @default.
- W3131650987 cites W2134585986 @default.
- W3131650987 cites W2135522980 @default.
- W3131650987 cites W2135718342 @default.
- W3131650987 cites W2138475604 @default.
- W3131650987 cites W2138917119 @default.
- W3131650987 cites W2138977668 @default.
- W3131650987 cites W2139264742 @default.
- W3131650987 cites W2142337984 @default.
- W3131650987 cites W2144730964 @default.
- W3131650987 cites W2145041062 @default.
- W3131650987 cites W2150523249 @default.
- W3131650987 cites W2150994376 @default.
- W3131650987 cites W2154945114 @default.
- W3131650987 cites W2156969855 @default.
- W3131650987 cites W2157811993 @default.
- W3131650987 cites W2160249662 @default.
- W3131650987 cites W2165915651 @default.
- W3131650987 cites W2186898572 @default.
- W3131650987 cites W2234902113 @default.
- W3131650987 cites W2239163788 @default.
- W3131650987 cites W2250201184 @default.
- W3131650987 cites W2288912078 @default.
- W3131650987 cites W2376741234 @default.
- W3131650987 cites W2380796370 @default.
- W3131650987 cites W2411026168 @default.
- W3131650987 cites W2462775742 @default.
- W3131650987 cites W2466362243 @default.
- W3131650987 cites W2468114364 @default.
- W3131650987 cites W2508206631 @default.
- W3131650987 cites W2518689955 @default.
- W3131650987 cites W2539567223 @default.
- W3131650987 cites W2567376791 @default.
- W3131650987 cites W2569961244 @default.
- W3131650987 cites W2581446635 @default.
- W3131650987 cites W2590354685 @default.
- W3131650987 cites W2591814334 @default.
- W3131650987 cites W2594036075 @default.
- W3131650987 cites W2604429195 @default.
- W3131650987 cites W2607420694 @default.
- W3131650987 cites W2609919034 @default.
- W3131650987 cites W2610189828 @default.
- W3131650987 cites W2611743264 @default.
- W3131650987 cites W2617594540 @default.