FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131662034> ?p ?o ?g. }

• W3131662034 abstract "Background: Serum lactic acid is considered a prognostic indicator in critically ill patients. However, studies on linezolid-induced lactic acidosis (LILA) are still limited. Individuals older than 85 years old (very elderly) have limited capacity for organ compensation, and LILA data from these patients are lacking. In this study, we evaluated the risk factors for LILA in patients older than 85 years and established a risk prediction model for geriatric practice. Methods: In this retrospective cohort study, blood gas analysis data and arterial lactate levels were monitored in patients older than 85 years during the use of teicoplanin or linezolid. After propensity score matching analyses, we compared the incidence of lactic acidosis between the teicoplanin and linezolid therapy groups and identified the risk factors of LILA. Results: The incidence of lactic acidosis was found to be much lower in the group receiving teicoplanin than those receiving linezolid therapy (0 vs. 35.7%; p &lt; 0.0001). A duration of linezolid therapy ≥ 9 days [odds ratio (OR), 3.541; 95% confidence interval (CI), 1.161–10.793; p = 0.026], an arterial blood glucose level ≥ 8 mmol/L (OR, 4.548; 95% CI, 1.507–13.725; p = 0.007), and a high sequential organ failure assessment score (OR, 1.429; 95% CI, 1.213–1.685; p &lt; 0.0001) were risk factors for LILA. The constructed risk model could be used to predict LILA (area under the curve, 0.849; specificity, 65.1%; sensitivity, 91.4%, with a negative predictive value of 93.2% and a positive predictive value of 59.3%). Conclusions: LILA can occur in patients older than 85 years after a relatively shorter duration of linezolid therapy. Therefore, close monitoring of blood gas and arterial lactate levels during linezolid therapy in the very elderly population is necessary." @default.
• W3131662034 created "2021-03-01" @default.
• W3131662034 creator A5009598980 @default.
• W3131662034 creator A5019685128 @default.
• W3131662034 creator A5034845971 @default.
• W3131662034 creator A5041324566 @default.
• W3131662034 creator A5044856789 @default.
• W3131662034 creator A5062907871 @default.
• W3131662034 creator A5076863688 @default.
• W3131662034 creator A5079670607 @default.
• W3131662034 creator A5085857963 @default.
• W3131662034 date "2021-02-25" @default.
• W3131662034 modified "2023-10-01" @default.
• W3131662034 title "Incidence and Associated Risk Factors for Lactic Acidosis Induced by Linezolid Therapy in a Case–Control Study in Patients Older Than 85 Years" @default.
• W3131662034 cites W1967055281 @default.
• W3131662034 cites W1978377718 @default.
• W3131662034 cites W1988279180 @default.
• W3131662034 cites W1994320720 @default.
• W3131662034 cites W1999479119 @default.
• W3131662034 cites W2009289882 @default.
• W3131662034 cites W2013303722 @default.
• W3131662034 cites W2027256091 @default.
• W3131662034 cites W2048860161 @default.
• W3131662034 cites W2059294934 @default.
• W3131662034 cites W2090649521 @default.
• W3131662034 cites W2092973221 @default.
• W3131662034 cites W2098301775 @default.
• W3131662034 cites W2108169618 @default.
• W3131662034 cites W2111883268 @default.
• W3131662034 cites W2112826871 @default.
• W3131662034 cites W2113140757 @default.
• W3131662034 cites W2132670832 @default.
• W3131662034 cites W2138781338 @default.
• W3131662034 cites W2142616307 @default.
• W3131662034 cites W2164326034 @default.
• W3131662034 cites W2171152889 @default.
• W3131662034 cites W2268054989 @default.
• W3131662034 cites W2280404143 @default.
• W3131662034 cites W2322964898 @default.
• W3131662034 cites W2512409286 @default.
• W3131662034 cites W2516982490 @default.
• W3131662034 cites W2527444122 @default.
• W3131662034 cites W2529945803 @default.
• W3131662034 cites W2564499404 @default.
• W3131662034 cites W2617318576 @default.
• W3131662034 cites W2773447229 @default.
• W3131662034 cites W2889989302 @default.
• W3131662034 doi "https://doi.org/10.3389/fmed.2021.604680" @default.
• W3131662034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7959744" @default.
• W3131662034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33732712" @default.
• W3131662034 hasPublicationYear "2021" @default.
• W3131662034 type Work @default.
• W3131662034 sameAs 3131662034 @default.
• W3131662034 citedByCount "1" @default.
• W3131662034 countsByYear W31316620342021 @default.
• W3131662034 crossrefType "journal-article" @default.
• W3131662034 hasAuthorship W3131662034A5009598980 @default.
• W3131662034 hasAuthorship W3131662034A5019685128 @default.
• W3131662034 hasAuthorship W3131662034A5034845971 @default.
• W3131662034 hasAuthorship W3131662034A5041324566 @default.
• W3131662034 hasAuthorship W3131662034A5044856789 @default.
• W3131662034 hasAuthorship W3131662034A5062907871 @default.
• W3131662034 hasAuthorship W3131662034A5076863688 @default.
• W3131662034 hasAuthorship W3131662034A5079670607 @default.
• W3131662034 hasAuthorship W3131662034A5085857963 @default.
• W3131662034 hasBestOaLocation W31316620341 @default.
• W3131662034 hasConcept C120665830 @default.
• W3131662034 hasConcept C121332964 @default.
• W3131662034 hasConcept C126322002 @default.
• W3131662034 hasConcept C156957248 @default.
• W3131662034 hasConcept C167135981 @default.
• W3131662034 hasConcept C17923572 @default.
• W3131662034 hasConcept C2778980435 @default.
• W3131662034 hasConcept C2779489039 @default.
• W3131662034 hasConcept C2780317664 @default.
• W3131662034 hasConcept C2781414143 @default.
• W3131662034 hasConcept C50440223 @default.
• W3131662034 hasConcept C523546767 @default.
• W3131662034 hasConcept C54355233 @default.
• W3131662034 hasConcept C61511704 @default.
• W3131662034 hasConcept C71924100 @default.
• W3131662034 hasConcept C86803240 @default.
• W3131662034 hasConceptScore W3131662034C120665830 @default.
• W3131662034 hasConceptScore W3131662034C121332964 @default.
• W3131662034 hasConceptScore W3131662034C126322002 @default.
• W3131662034 hasConceptScore W3131662034C156957248 @default.
• W3131662034 hasConceptScore W3131662034C167135981 @default.
• W3131662034 hasConceptScore W3131662034C17923572 @default.
• W3131662034 hasConceptScore W3131662034C2778980435 @default.
• W3131662034 hasConceptScore W3131662034C2779489039 @default.
• W3131662034 hasConceptScore W3131662034C2780317664 @default.
• W3131662034 hasConceptScore W3131662034C2781414143 @default.
• W3131662034 hasConceptScore W3131662034C50440223 @default.
• W3131662034 hasConceptScore W3131662034C523546767 @default.
• W3131662034 hasConceptScore W3131662034C54355233 @default.
• W3131662034 hasConceptScore W3131662034C61511704 @default.
• W3131662034 hasConceptScore W3131662034C71924100 @default.
• W3131662034 hasConceptScore W3131662034C86803240 @default.
• W3131662034 hasLocation W31316620341 @default.
• W3131662034 hasLocation W31316620342 @default.

• next