Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131713514> ?p ?o ?g. }
- W3131713514 endingPage "103291" @default.
- W3131713514 startingPage "103291" @default.
- W3131713514 abstract "Given that heterosexual transmission of HIV across the genital mucosa is the most common route of infection in women, an in-depth understanding of the biological mechanisms associated with HIV risk in the female genital tract (FGT) is essential for effective control of the epidemic. Genital pro-inflammatory cytokines are well-described biological co-factors to HIV risk. Increased levels of pro-inflammatory cytokines in the FGT have been associated with a 3-fold higher-risk of acquiring HIV, presumably through involvement in barrier compromise and the recruitment of highly activated HIV target cells to the site of initial viral infection and replication. Sexually transmitted infections (STIs) and bacterial vaginosis (BV) are suggested possible contributors to genital inflammation in the FGT, and this, coupled with the relationship between genital inflammation and HIV risk, underscores the importance of effective treatment of STI and BV in the promotion of women's health. In most low- and middle-income countries, STIs are treated syndromically, a practice providing rapid treatment without identifying the infection source. However, this approach has been associated with over-diagnosis and the overuse of drugs. Further, because many women with STIs are asymptomatic, syndromic management also fails to treat a vast proportion of infected women. Although several studies have explored the role of STIs and the vaginal microbiome on genital inflammation and HIV risk, the impact of STI and BV management on genital inflammation remains poorly understood. This review aimed to collate the evidence on how BV and STI management efforts affect genital inflammation and the genital microbiome in women." @default.
- W3131713514 created "2021-03-01" @default.
- W3131713514 creator A5004892469 @default.
- W3131713514 creator A5007528258 @default.
- W3131713514 creator A5019395957 @default.
- W3131713514 creator A5043098641 @default.
- W3131713514 creator A5066294945 @default.
- W3131713514 date "2021-06-01" @default.
- W3131713514 modified "2023-10-17" @default.
- W3131713514 title "HIV susceptibility in women: The roles of genital inflammation, sexually transmitted infections and the genital microbiome" @default.
- W3131713514 cites W148594346 @default.
- W3131713514 cites W1535411667 @default.
- W3131713514 cites W1548772785 @default.
- W3131713514 cites W1919603305 @default.
- W3131713514 cites W1942052314 @default.
- W3131713514 cites W1966676297 @default.
- W3131713514 cites W1978962263 @default.
- W3131713514 cites W1979325171 @default.
- W3131713514 cites W2013386415 @default.
- W3131713514 cites W2016168268 @default.
- W3131713514 cites W2023506796 @default.
- W3131713514 cites W2025615480 @default.
- W3131713514 cites W2032329981 @default.
- W3131713514 cites W2034736786 @default.
- W3131713514 cites W2036140706 @default.
- W3131713514 cites W2036951019 @default.
- W3131713514 cites W2038136652 @default.
- W3131713514 cites W2046435095 @default.
- W3131713514 cites W2046625034 @default.
- W3131713514 cites W2050332051 @default.
- W3131713514 cites W2051033048 @default.
- W3131713514 cites W2058566083 @default.
- W3131713514 cites W2060817045 @default.
- W3131713514 cites W2062250995 @default.
- W3131713514 cites W2062761055 @default.
- W3131713514 cites W2065032362 @default.
- W3131713514 cites W2066218616 @default.
- W3131713514 cites W2071366643 @default.
- W3131713514 cites W2078489697 @default.
- W3131713514 cites W2081875375 @default.
- W3131713514 cites W2089549507 @default.
- W3131713514 cites W2097250129 @default.
- W3131713514 cites W2097304393 @default.
- W3131713514 cites W2097648465 @default.
- W3131713514 cites W2098952861 @default.
- W3131713514 cites W2100727985 @default.
- W3131713514 cites W2102344946 @default.
- W3131713514 cites W2104635909 @default.
- W3131713514 cites W2105053076 @default.
- W3131713514 cites W2112059343 @default.
- W3131713514 cites W2112965458 @default.
- W3131713514 cites W2115792826 @default.
- W3131713514 cites W2117874572 @default.
- W3131713514 cites W2119268665 @default.
- W3131713514 cites W2125189266 @default.
- W3131713514 cites W2132950641 @default.
- W3131713514 cites W2138310412 @default.
- W3131713514 cites W2140074301 @default.
- W3131713514 cites W2140940913 @default.
- W3131713514 cites W2143197985 @default.
- W3131713514 cites W2143300095 @default.
- W3131713514 cites W2144191726 @default.
- W3131713514 cites W2145261922 @default.
- W3131713514 cites W2145845923 @default.
- W3131713514 cites W2147004466 @default.
- W3131713514 cites W2154319118 @default.
- W3131713514 cites W2156478713 @default.
- W3131713514 cites W2160226661 @default.
- W3131713514 cites W2161358581 @default.
- W3131713514 cites W2162703129 @default.
- W3131713514 cites W2163488022 @default.
- W3131713514 cites W2168782703 @default.
- W3131713514 cites W2169881537 @default.
- W3131713514 cites W2337781952 @default.
- W3131713514 cites W2340517588 @default.
- W3131713514 cites W2406234593 @default.
- W3131713514 cites W2462257795 @default.
- W3131713514 cites W2511956165 @default.
- W3131713514 cites W2552883321 @default.
- W3131713514 cites W2554468640 @default.
- W3131713514 cites W2557801288 @default.
- W3131713514 cites W2569893930 @default.
- W3131713514 cites W2571049130 @default.
- W3131713514 cites W2588188994 @default.
- W3131713514 cites W2605651569 @default.
- W3131713514 cites W2734302978 @default.
- W3131713514 cites W2755799373 @default.
- W3131713514 cites W2761941565 @default.
- W3131713514 cites W2772115897 @default.
- W3131713514 cites W2792916938 @default.
- W3131713514 cites W2810934340 @default.
- W3131713514 cites W2884221096 @default.
- W3131713514 cites W2884579947 @default.
- W3131713514 cites W2887815749 @default.
- W3131713514 cites W2890794725 @default.
- W3131713514 cites W2902250991 @default.
- W3131713514 cites W2907659791 @default.
- W3131713514 cites W2923155713 @default.