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• W3131727259 endingPage "110578" @default.
• W3131727259 startingPage "110578" @default.
• W3131727259 abstract "MiR-150 is a microRNA (miRNA) present in a number of teleost species, but its target and regulation mechanism are unknown. Similarly, lysosome membrane protein 2-like (LMP2L) is a gene identified in fish but with unknown function. In this study, we examined the regulation mechanism and function of flounder miR-150 (named pol-miR-150) and its target gene LMP2L (named PoLMP2L) in association with bacterial and viral infection. We found that pol-miR-150 expression was not only modulated by the bacterial pathogen Streptococcus iniae but also by the viral pathogen megalocytivirus. Pol-miR-150 targeted PoLMP2L by binding to the 3′-untranslated region (3'-UTR) of PoLMP2L and inhibited PoLMP2L expression in vitro and in vivo . PoLMP2L is a member of the CD36 superfamily of scavenger receptors and homologous to but phylogenetically distinct from lysosomal integral membrane protein type 2 (LIMP2). PoLMP2L was localized mainly in the lysosomes and expressed in multiple organs of flounder. In vivo knockdown and overexpression of PoLMP2L enhanced and suppressed, respectively, S. iniae dissemination in flounder tissues, whereas in vivo knockdown and overexpression of pol-miR-150 produced the opposite effects on S. iniae dissemination. In addition, pol-miR-150 knockdown also significantly inhibited the replication of megalocytivirus. The results of this study revealed the regulation mechanism and immune functions of fish miR-150 and LMP2L, and indicated that LMP2L and miR-150 play an important role in the antimicrobial immunity of fish. • Pol-miR-150 expression was regulated by Streptococcus iniae and megalocytivirus. • PoLMP2L was the target gene of pol-miR-150 and inhibited by the latter. • PoLMP2L was localized mainly in the lysosomes and expressed in multiple tissues. • Overexpression/knockdown of PoLMP2L and pol-miR-150 affected S . iniae infection. • Pol-miR-150 knockdown also significantly affected megalocytivirus replication." @default.
• W3131727259 created "2021-03-01" @default.
• W3131727259 creator A5005411386 @default.
• W3131727259 creator A5027619452 @default.
• W3131727259 creator A5061849630 @default.
• W3131727259 date "2021-06-01" @default.
• W3131727259 modified "2023-10-17" @default.
• W3131727259 title "Pol-miR-150 regulates anti-bacterial and viral infection in Japanese flounder (Paralichthys olivaceus) via the lysosomal protein LMP2L" @default.
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• W3131727259 doi "https://doi.org/10.1016/j.cbpb.2021.110578" @default.
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