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- W3131764429 abstract "Abstract Thioredoxin (Trx) system plays a crucial role as an electron donor for ribonucleotide reductase (RNR), which catalyzes the formation of deoxyribonucleotides for DNA synthesis. Here, we show that the S‐nitrosylation of the R1 subunit inhibits RNR catalysis and that the enzyme activity is restored via denitrosylation mediated by shuttle dithiols (in a CXXC motif) of the R1 C‐terminal tail or by an externally supplied R1 C‐terminal peptide (containing vicinal dithiols), in case of a R1 C‐terminal mutant. The Trx system was found to be necessary for regeneration of the oxidized vicinal dithiols in the C‐terminal tail/peptide. Our results with recombinant RNR highlighted the importance of C‐terminal vicinal dithiols of R1, in regenerating the RNR activity of S‐nitrosylated R1 subunits. This study will contribute towards a better understanding of S‐(de)nitrosylation mediated regulation of RNR activity." @default.
- W3131764429 created "2021-03-01" @default.
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- W3131764429 date "2021-02-19" @default.
- W3131764429 modified "2023-10-03" @default.
- W3131764429 title "S‐Denitrosylation by the C‐Terminal Swinging Arm of R1 Subunit: A Novel Mechanism to Restore Ribonucleotide Reductase Activity" @default.
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- W3131764429 doi "https://doi.org/10.1002/slct.202100153" @default.
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