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• W3131799440 abstract "La préservation de la fertilité est indispensable avant tout traitement du cancer. En cas d’échec à la conservation de spermatozoïdes éjaculés, un prélèvement chirurgical de tissu testiculaire est possible dans le cadre d’une Onco-TESE (Oncological Testicular Sperm Extraction) afin d’isoler des spermatozoïdes. Nous rapportons notre expérience d’Onco-TESE chez les patients atteints d’un cancer du testicule, au sein du CHU de Rouen. Étude rétrospective incluant l’ensemble des hommes pubères, prise en charge pour un cancer du testicule, uni ou bilatéral, avant tout traitement carcinologique, ayant bénéficié d’une Onco-TESE au CHU de Rouen. Le poids des fragments, la présence de spermatozoïdes ou de ses précurseurs ont été analysés. Une relecture histologique des pièces d’orchidectomies a été effectuée. Pour chaque prélèvement positif, des paillettes ont été conservées au CECOS. Vingt-quatres patients ont eu une Onco-TESE : 58,34 % altération sévère du spermogramme (ASS) et 41,36 % échec de recueil de sperme (ERS), entre 1996 et 2019. L’âge moyen était de 26,6 (±5,29) ans. Les durées moyennes de l’intervention et de séjour étaient respectivement de 71 minutes (±30,7) et de 3,75 jours (±2,83). Le taux de biopsies testiculaire (BT) positives était de 58,33 % de façon général et de 66,67 % en cas de BT sur testicule tumoral. Un patient a présenté une complication Clavien III. Le nombre moyen de paillettes conservées par patient était de 14,28 (±15,34) pour 7,14 % d’utilisation. Nos résultats semblent confirmer que l’Onco-TESE est une solution efficace pour préserver la fertilité des hommes atteints de cancer du testicule en cas d’ASS ou d’ERS. III. Fertility preservation is essential before cancer treatment. When ejaculated sperm preservation is not possible, testicular tissue can be surgically collected by Onco-TESE technic (Oncological Testicular Sperm Extraction) to isolate sperm. We report on our experience with Onco-TESE in testicular cancer patients at the Rouen University Hospital. Retrospective study including all pubescent men, treated for testicular cancer, uni- or bilateral, before any carcinological therapy, who have undergone Onco-TESE at the Rouen University Hospital. Fragment weight, detection of sperm or its precursors were analysed. A histological interpretation of the testicular tumor was carried out. For each positive sample, straws were kept at the French Sperm Bank. Twenty-four patients had an Onco-TESE: 58.34% severe sperm alteration (SSA) and 41.36% sperm collection failure (SCF), between 1996 and 2019. The mean age was 26.6 (±5.29) years. The mean procedure and length of stay were 71 minutes (±30.7) and 3.75 days (±2.83), respectively. The rate of positive testicular biopsies (TB) was 58.33% overall and 66,67% in the case of TB on tumour testis. One patient had a Clavian-Dindo III complication. The mean number of straws preserved per patient was 14.28 (±15.34) for 7.14% use. Our results seem to confirm that Onco-TESE is an effective solution for preserving fertility in men with testicular cancer in cases of SSA or SCF. III." @default.
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• W3131799440 date "2021-04-01" @default.
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• W3131799440 title "Onco-TESE et cancer du testicule" @default.
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• W3131799440 doi "https://doi.org/10.1016/j.purol.2020.09.019" @default.
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