Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131859000> ?p ?o ?g. }
- W3131859000 endingPage "113936" @default.
- W3131859000 startingPage "113936" @default.
- W3131859000 abstract "Synthetic drugs used for cancer treatment have side effects that may be immunosupressive, can cause liver, kidney and cardiac toxicity, and infertility and ovarian failure, among others. Thus, herbal drugs could be used in the cancer treatment as an adjuvant therapy. Andrographis paniculata (Burm.f.) Nees (AP) is one of the traditional herbs used in different alternative medicinal systems such as Ayurveda, Unani, Chinese, Malayi, Siddha, etc. for the treatment of various disorders and diseases including cancer. The aim of writing this review is to highlight the medicinal importance of AP and its main phytoconstituent andrographolide (AG). The main emphasis was given on the anticancer activity of AG, its proposed mechanisms of action, novel approaches used to improve its biopharmaceutical properties with the perspective of evidence-based research, and its development as an adjuvant therapy for cancer treatment in future. Literature survey was conducted and research papers were retrieved from different databases such as Pubmed, Google Scholar, ACS, Wiley online library, ScienceDirect, Springer, and Scopus during 1970–2020. Research articles, review articles, and short communications, etc. were used for this purpose. The papers were selected on the basis of exclusion and inclusion criteria. Different anticancer mechanisms of AG have been reportedly proven such as cell cycle arrest, apoptosis, NF-κβ inhibition, antiangiogenesis, cytokine inhibition, etc. whereas its pharmacokinetic properties showed its highly protein bound nature, Cyt P400 (CYP) inhibition, low aqueous solubility, poor oral bioavailability, etc. Different novel formulations of AG have been investigated to increase its bioavailability for better efficacy. This review can provide knowledge about the potential applicability of AP or AG as an adjuvant therapy in cancer treatment. Further research is needed before making any conclusion about the efficacy in humans as an adjuvant therapy in cancer." @default.
- W3131859000 created "2021-03-01" @default.
- W3131859000 creator A5007712340 @default.
- W3131859000 creator A5024883122 @default.
- W3131859000 creator A5034826221 @default.
- W3131859000 creator A5040819285 @default.
- W3131859000 creator A5041292243 @default.
- W3131859000 creator A5048747823 @default.
- W3131859000 creator A5056003187 @default.
- W3131859000 creator A5075627594 @default.
- W3131859000 creator A5087937019 @default.
- W3131859000 date "2021-05-01" @default.
- W3131859000 modified "2023-09-27" @default.
- W3131859000 title "Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action" @default.
- W3131859000 cites W104311899 @default.
- W3131859000 cites W1505278194 @default.
- W3131859000 cites W1551309927 @default.
- W3131859000 cites W1966286435 @default.
- W3131859000 cites W1967020486 @default.
- W3131859000 cites W1967492443 @default.
- W3131859000 cites W1972566887 @default.
- W3131859000 cites W1979376672 @default.
- W3131859000 cites W1979571397 @default.
- W3131859000 cites W1979959757 @default.
- W3131859000 cites W1987147444 @default.
- W3131859000 cites W1989694559 @default.
- W3131859000 cites W1990092707 @default.
- W3131859000 cites W1991921320 @default.
- W3131859000 cites W1993034915 @default.
- W3131859000 cites W1995898317 @default.
- W3131859000 cites W1997359763 @default.
- W3131859000 cites W1997790083 @default.
- W3131859000 cites W2000252737 @default.
- W3131859000 cites W2001332591 @default.
- W3131859000 cites W2005193397 @default.
- W3131859000 cites W2007105598 @default.
- W3131859000 cites W2008608828 @default.
- W3131859000 cites W2008879251 @default.
- W3131859000 cites W2011805324 @default.
- W3131859000 cites W2012804923 @default.
- W3131859000 cites W2013873169 @default.
- W3131859000 cites W2016648276 @default.
- W3131859000 cites W2017294609 @default.
- W3131859000 cites W2018352938 @default.
- W3131859000 cites W2019162634 @default.
- W3131859000 cites W2019649444 @default.
- W3131859000 cites W2019997499 @default.
- W3131859000 cites W2020518991 @default.
- W3131859000 cites W2020963879 @default.
- W3131859000 cites W2021980400 @default.
- W3131859000 cites W2022622460 @default.
- W3131859000 cites W2023659954 @default.
- W3131859000 cites W2024211026 @default.
- W3131859000 cites W2025967915 @default.
- W3131859000 cites W2027502736 @default.
- W3131859000 cites W2029597938 @default.
- W3131859000 cites W2030889457 @default.
- W3131859000 cites W2031345071 @default.
- W3131859000 cites W2037403296 @default.
- W3131859000 cites W2038018133 @default.
- W3131859000 cites W2038581426 @default.
- W3131859000 cites W2041224389 @default.
- W3131859000 cites W2043577758 @default.
- W3131859000 cites W2045792033 @default.
- W3131859000 cites W2045985825 @default.
- W3131859000 cites W2048945841 @default.
- W3131859000 cites W2050111264 @default.
- W3131859000 cites W2052671216 @default.
- W3131859000 cites W2053302596 @default.
- W3131859000 cites W2054618769 @default.
- W3131859000 cites W2057575288 @default.
- W3131859000 cites W2058017479 @default.
- W3131859000 cites W2061176839 @default.
- W3131859000 cites W2062531379 @default.
- W3131859000 cites W2064247666 @default.
- W3131859000 cites W2065081315 @default.
- W3131859000 cites W2065715669 @default.
- W3131859000 cites W2068084252 @default.
- W3131859000 cites W2068142406 @default.
- W3131859000 cites W2068290654 @default.
- W3131859000 cites W2068626280 @default.
- W3131859000 cites W2069464990 @default.
- W3131859000 cites W2071425979 @default.
- W3131859000 cites W2076497495 @default.
- W3131859000 cites W2076841532 @default.
- W3131859000 cites W2083202884 @default.
- W3131859000 cites W2083447035 @default.
- W3131859000 cites W2084634883 @default.
- W3131859000 cites W2087929997 @default.
- W3131859000 cites W2088455943 @default.
- W3131859000 cites W2091038079 @default.
- W3131859000 cites W2092981916 @default.
- W3131859000 cites W2095383156 @default.
- W3131859000 cites W2104136026 @default.
- W3131859000 cites W2110278147 @default.
- W3131859000 cites W2110777903 @default.
- W3131859000 cites W2114531054 @default.
- W3131859000 cites W2116002233 @default.