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- W3131885224 endingPage "296" @default.
- W3131885224 startingPage "296" @default.
- W3131885224 abstract "Sickle cell disease (SCD) is the most common hereditary disorder of hemoglobin (Hb), which affects approximately a million people worldwide. It is characterized by a single nucleotide substitution in the β-globin gene, leading to the production of abnormal sickle hemoglobin (HbS) with multi-system consequences. HbS polymerization is the primary event in SCD. Repeated polymerization and depolymerization of Hb causes oxidative stress that plays a key role in the pathophysiology of hemolysis, vessel occlusion and the following organ damage in sickle cell patients. For this reason, reactive oxidizing species and the (end)-products of their oxidative reactions have been proposed as markers of both tissue pro-oxidant status and disease severity. Although more studies are needed to clarify their role, antioxidant agents have been shown to be effective in reducing pathological consequences of the disease by preventing oxidative damage in SCD, i.e., by decreasing the oxidant formation or repairing the induced damage. An improved understanding of oxidative stress will lead to targeted antioxidant therapies that should prevent or delay the development of organ complications in this patient population." @default.
- W3131885224 created "2021-03-01" @default.
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- W3131885224 creator A5062137970 @default.
- W3131885224 creator A5065762789 @default.
- W3131885224 creator A5065873008 @default.
- W3131885224 date "2021-02-16" @default.
- W3131885224 modified "2023-10-03" @default.
- W3131885224 title "Sickle Cell Disease: Role of Oxidative Stress and Antioxidant Therapy" @default.
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