Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131955877> ?p ?o ?g. }
- W3131955877 endingPage "105758" @default.
- W3131955877 startingPage "105758" @default.
- W3131955877 abstract "The bioavailability of conventional eye drops is very low due to different physiological barriers. Commercial latanoprost (LAT) eye drops (Xalatan®) need to be refrigerated and protected from light. The purpose of this study was to develop novel LAT eye drops to improve ocular bioavailability and stability. Ophthalmic suspension containing LAT/γ-cyclodextrin (γCD) aggregates was designed and the preparation process was sufficiently studied. The prepared formulations were evaluated for pH, viscosity, osmolality, particle size, entrapment efficiency and in vitro release study. In vitro permeability study using Human Corneal Epithelial Cells and in vivo studies on rabbits were also performed. LAT/γCD aggregates were formed and confirmed by scanning electron microscopy. LAT/γCD eye drops showed obvious sustained release profiles and were more stable than Xalatan®. In vitro corneal permeation study indicated LAT/γCD eye drops had no significant cytotoxicity and had higher cell permeability. In vivo precorneal retention study showed AUC0–6 h, Cmax, and mean residence time (MRT) of LAT/γCD eye drops were 3.98, 2.12, and 2.07 times higher than those of Xalatan®, respectively. In vivo ocular distribution study revealed that AUC0–24 h, Cmax, and MRT for latanoprost acid in aqueous humor exhibited 2.60-fold, 1.36-fold, and 1.99-fold increase in LAT/γCD eye drops group than those of Xalatan® group, respectively. Cyclodextrin microaggregate suspension eye drops represent a potential strategy for enhanced bioavailability and stability of LAT." @default.
- W3131955877 created "2021-03-01" @default.
- W3131955877 creator A5016597797 @default.
- W3131955877 creator A5021758916 @default.
- W3131955877 creator A5022526821 @default.
- W3131955877 creator A5061857531 @default.
- W3131955877 creator A5069263167 @default.
- W3131955877 date "2021-05-01" @default.
- W3131955877 modified "2023-10-18" @default.
- W3131955877 title "Latanoprost-loaded cyclodextrin microaggregate suspension eye drops for enhanced bioavailability and stability" @default.
- W3131955877 cites W1545517239 @default.
- W3131955877 cites W1568412294 @default.
- W3131955877 cites W162422877 @default.
- W3131955877 cites W1913115111 @default.
- W3131955877 cites W1969373623 @default.
- W3131955877 cites W1985689227 @default.
- W3131955877 cites W1988801567 @default.
- W3131955877 cites W1994438083 @default.
- W3131955877 cites W2005090059 @default.
- W3131955877 cites W2034011121 @default.
- W3131955877 cites W2059183805 @default.
- W3131955877 cites W2064135629 @default.
- W3131955877 cites W2065249270 @default.
- W3131955877 cites W2065419721 @default.
- W3131955877 cites W2074582913 @default.
- W3131955877 cites W2079863919 @default.
- W3131955877 cites W2080292900 @default.
- W3131955877 cites W2094486190 @default.
- W3131955877 cites W2102002215 @default.
- W3131955877 cites W2119967773 @default.
- W3131955877 cites W2342776814 @default.
- W3131955877 cites W2599118345 @default.
- W3131955877 cites W2605156143 @default.
- W3131955877 cites W2767842869 @default.
- W3131955877 cites W2796642336 @default.
- W3131955877 cites W2799627453 @default.
- W3131955877 cites W2799889452 @default.
- W3131955877 cites W2908945477 @default.
- W3131955877 cites W2986903386 @default.
- W3131955877 cites W3016073025 @default.
- W3131955877 cites W4206485229 @default.
- W3131955877 doi "https://doi.org/10.1016/j.ejps.2021.105758" @default.
- W3131955877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33588044" @default.
- W3131955877 hasPublicationYear "2021" @default.
- W3131955877 type Work @default.
- W3131955877 sameAs 3131955877 @default.
- W3131955877 citedByCount "15" @default.
- W3131955877 countsByYear W31319558772021 @default.
- W3131955877 countsByYear W31319558772022 @default.
- W3131955877 countsByYear W31319558772023 @default.
- W3131955877 crossrefType "journal-article" @default.
- W3131955877 hasAuthorship W3131955877A5016597797 @default.
- W3131955877 hasAuthorship W3131955877A5021758916 @default.
- W3131955877 hasAuthorship W3131955877A5022526821 @default.
- W3131955877 hasAuthorship W3131955877A5061857531 @default.
- W3131955877 hasAuthorship W3131955877A5069263167 @default.
- W3131955877 hasConcept C118487528 @default.
- W3131955877 hasConcept C150903083 @default.
- W3131955877 hasConcept C181389837 @default.
- W3131955877 hasConcept C185592680 @default.
- W3131955877 hasConcept C207001950 @default.
- W3131955877 hasConcept C22979827 @default.
- W3131955877 hasConcept C2776740260 @default.
- W3131955877 hasConcept C2777625524 @default.
- W3131955877 hasConcept C2778527774 @default.
- W3131955877 hasConcept C2779433975 @default.
- W3131955877 hasConcept C41625074 @default.
- W3131955877 hasConcept C43617362 @default.
- W3131955877 hasConcept C50670333 @default.
- W3131955877 hasConcept C55493867 @default.
- W3131955877 hasConcept C71924100 @default.
- W3131955877 hasConcept C86803240 @default.
- W3131955877 hasConcept C98274493 @default.
- W3131955877 hasConceptScore W3131955877C118487528 @default.
- W3131955877 hasConceptScore W3131955877C150903083 @default.
- W3131955877 hasConceptScore W3131955877C181389837 @default.
- W3131955877 hasConceptScore W3131955877C185592680 @default.
- W3131955877 hasConceptScore W3131955877C207001950 @default.
- W3131955877 hasConceptScore W3131955877C22979827 @default.
- W3131955877 hasConceptScore W3131955877C2776740260 @default.
- W3131955877 hasConceptScore W3131955877C2777625524 @default.
- W3131955877 hasConceptScore W3131955877C2778527774 @default.
- W3131955877 hasConceptScore W3131955877C2779433975 @default.
- W3131955877 hasConceptScore W3131955877C41625074 @default.
- W3131955877 hasConceptScore W3131955877C43617362 @default.
- W3131955877 hasConceptScore W3131955877C50670333 @default.
- W3131955877 hasConceptScore W3131955877C55493867 @default.
- W3131955877 hasConceptScore W3131955877C71924100 @default.
- W3131955877 hasConceptScore W3131955877C86803240 @default.
- W3131955877 hasConceptScore W3131955877C98274493 @default.
- W3131955877 hasFunder F4320321001 @default.
- W3131955877 hasLocation W31319558771 @default.
- W3131955877 hasOpenAccess W3131955877 @default.
- W3131955877 hasPrimaryLocation W31319558771 @default.
- W3131955877 hasRelatedWork W1966103856 @default.
- W3131955877 hasRelatedWork W2005720293 @default.
- W3131955877 hasRelatedWork W2010632629 @default.
- W3131955877 hasRelatedWork W2018483608 @default.