Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131987965> ?p ?o ?g. }
- W3131987965 abstract "GLP-1 analogs have been widely used to treat patients with type 2 diabetes in recent years and studies have found that GLP-1 analogs have multiple organ benefits. However, the role of GLP-1 analogs in diabetic retinopathy (DR), a common complication of diabetes mellitus (DM), remains controversial. Retinal ganglion cells (RGCs) are the only afferent neurons responsible for transmitting visual information to the visual center and are vulnerable in the early stage of DR. Protection of RGC is vital for visual function. The incretin glucagon-like peptide-1 (GLP-1), which is secreted by L-cells after food ingestion, could lower blood glucose level through stimulating the release of insulin. In the present study, we evaluated the effects of GLP-1 analog on RGCs both in vitro and in vivo . We established diabetic rat models in vivo and applied an RGC-5 cell line in vitro . The results showed that in high glucose conditions, GLP-1 analog alleviated the damage of RGCs. In addition, GLP-1 analog prevented mitophagy through the PINK1/Parkin pathway. Here we demonstrated the neuroprotective effect of GLP-1 analog, which may be beneficial for retinal function, and we further elucidated a novel mechanism in GLP-1 analog-regulated protection of the retina. These findings may expand the multi-organ benefits of GLP-1 analogs and provide new insights for the prevention of DR." @default.
- W3131987965 created "2021-03-01" @default.
- W3131987965 creator A5021762767 @default.
- W3131987965 creator A5024736961 @default.
- W3131987965 creator A5026542035 @default.
- W3131987965 creator A5029015256 @default.
- W3131987965 creator A5041927337 @default.
- W3131987965 creator A5059844042 @default.
- W3131987965 creator A5063268197 @default.
- W3131987965 creator A5091054508 @default.
- W3131987965 date "2021-02-12" @default.
- W3131987965 modified "2023-10-13" @default.
- W3131987965 title "Neuroprotective Role of GLP-1 Analog for Retinal Ganglion Cells via PINK1/Parkin-Mediated Mitophagy in Diabetic Retinopathy" @default.
- W3131987965 cites W126188432 @default.
- W3131987965 cites W1488049042 @default.
- W3131987965 cites W1569812687 @default.
- W3131987965 cites W1968843321 @default.
- W3131987965 cites W1979637734 @default.
- W3131987965 cites W1979766264 @default.
- W3131987965 cites W1985124617 @default.
- W3131987965 cites W1993249979 @default.
- W3131987965 cites W1993968665 @default.
- W3131987965 cites W1996609490 @default.
- W3131987965 cites W1996953529 @default.
- W3131987965 cites W2002757015 @default.
- W3131987965 cites W2004252899 @default.
- W3131987965 cites W2009715420 @default.
- W3131987965 cites W2020722847 @default.
- W3131987965 cites W2021439462 @default.
- W3131987965 cites W2028536701 @default.
- W3131987965 cites W2030270894 @default.
- W3131987965 cites W2037612627 @default.
- W3131987965 cites W2039762060 @default.
- W3131987965 cites W2039935344 @default.
- W3131987965 cites W2041485080 @default.
- W3131987965 cites W2041940338 @default.
- W3131987965 cites W2047242847 @default.
- W3131987965 cites W2055971882 @default.
- W3131987965 cites W2058837644 @default.
- W3131987965 cites W2078613171 @default.
- W3131987965 cites W2080199676 @default.
- W3131987965 cites W2087609283 @default.
- W3131987965 cites W2089728480 @default.
- W3131987965 cites W2116562304 @default.
- W3131987965 cites W2121836743 @default.
- W3131987965 cites W2123111197 @default.
- W3131987965 cites W2131007152 @default.
- W3131987965 cites W2151283457 @default.
- W3131987965 cites W2155528804 @default.
- W3131987965 cites W2168458739 @default.
- W3131987965 cites W2174781702 @default.
- W3131987965 cites W2196507910 @default.
- W3131987965 cites W2322869984 @default.
- W3131987965 cites W2335833703 @default.
- W3131987965 cites W2341475075 @default.
- W3131987965 cites W2417645219 @default.
- W3131987965 cites W2474000300 @default.
- W3131987965 cites W2539863867 @default.
- W3131987965 cites W2557944616 @default.
- W3131987965 cites W2578438729 @default.
- W3131987965 cites W2605488394 @default.
- W3131987965 cites W2726754850 @default.
- W3131987965 cites W2742669393 @default.
- W3131987965 cites W2775187110 @default.
- W3131987965 cites W2789933302 @default.
- W3131987965 cites W2794100172 @default.
- W3131987965 cites W2889608418 @default.
- W3131987965 cites W2902832527 @default.
- W3131987965 cites W2922318839 @default.
- W3131987965 cites W2936115703 @default.
- W3131987965 cites W2938989462 @default.
- W3131987965 cites W2944447415 @default.
- W3131987965 cites W2949110934 @default.
- W3131987965 cites W2965471311 @default.
- W3131987965 cites W4205771076 @default.
- W3131987965 cites W4211031298 @default.
- W3131987965 cites W4234207800 @default.
- W3131987965 cites W4244017022 @default.
- W3131987965 cites W4254304544 @default.
- W3131987965 cites W4256659255 @default.
- W3131987965 doi "https://doi.org/10.3389/fphar.2020.589114" @default.
- W3131987965 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7928389" @default.
- W3131987965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33679385" @default.
- W3131987965 hasPublicationYear "2021" @default.
- W3131987965 type Work @default.
- W3131987965 sameAs 3131987965 @default.
- W3131987965 citedByCount "17" @default.
- W3131987965 countsByYear W31319879652021 @default.
- W3131987965 countsByYear W31319879652022 @default.
- W3131987965 countsByYear W31319879652023 @default.
- W3131987965 crossrefType "journal-article" @default.
- W3131987965 hasAuthorship W3131987965A5021762767 @default.
- W3131987965 hasAuthorship W3131987965A5024736961 @default.
- W3131987965 hasAuthorship W3131987965A5026542035 @default.
- W3131987965 hasAuthorship W3131987965A5029015256 @default.
- W3131987965 hasAuthorship W3131987965A5041927337 @default.
- W3131987965 hasAuthorship W3131987965A5059844042 @default.
- W3131987965 hasAuthorship W3131987965A5063268197 @default.
- W3131987965 hasAuthorship W3131987965A5091054508 @default.
- W3131987965 hasBestOaLocation W31319879651 @default.