FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132012093> ?p ?o ?g. }

• W3132012093 abstract "Dysregulation of RNA binding proteins (RBPs) is closely associated with tumor events. However, the function of RBPs in hepatocellular carcinoma (HCC) has not been fully elucidated. The RNA sequences and relevant clinical data of HCC were retrieved from the The Cancer Genome Atlas (TCGA) database to identify distinct RBPs. Subsequently, univariate and multivariate cox regression analysis was performed to evaluate the overall survival (OS)-associated RBPs. The expression levels of prognostic RBP genes and survival information were analyzed using a series of bioinformatics tool. A total of 365 samples with 1,542 RBPs were included in this study. One hundred and eighty-seven differently RBPs were screened, including 175 up-regulated and 12 down-regulated. The independent OS-associated RBPs of NHP2, UPF3B , and SMG5 were used to develop a prognostic model. Survival analysis showed that low-risk patients had a significantly longer OS and disease-free survival (DFS) when compared to high-risk patients ( HR : 2.577, 95% CI : 1.793–3.704, P &lt; 0.001 and HR : 1.599, 95% CI : 1.185–2.159, P = 0.001, respectively). The International Cancer Genome Consortium (ICGC) database was used to externally validate the model, and the OS of low-risk patients were found to be longer than that of high-risk patients ( P &lt; 0.001). The Nomograms of OS and DFS were plotted to help in clinical decision making. These results showed that the model was effective and may help in prognostic stratification of HCC patients. The prognostic prediction model based on RBPs provides new insights for HCC diagnosis and personalized treatment." @default.
• W3132012093 created "2021-03-01" @default.
• W3132012093 creator A5010458663 @default.
• W3132012093 creator A5014120734 @default.
• W3132012093 creator A5014191568 @default.
• W3132012093 creator A5015716870 @default.
• W3132012093 creator A5026946651 @default.
• W3132012093 creator A5062051935 @default.
• W3132012093 creator A5088638269 @default.
• W3132012093 date "2021-02-12" @default.
• W3132012093 modified "2023-10-16" @default.
• W3132012093 title "A Prognostic Model Based on RNA Binding Protein Predicts Clinical Outcomes in Hepatocellular Carcinoma Patients" @default.
• W3132012093 cites W1977145129 @default.
• W3132012093 cites W1986077139 @default.
• W3132012093 cites W1989017470 @default.
• W3132012093 cites W1997535872 @default.
• W3132012093 cites W2009671859 @default.
• W3132012093 cites W2024395213 @default.
• W3132012093 cites W2063614307 @default.
• W3132012093 cites W2064508685 @default.
• W3132012093 cites W2099789788 @default.
• W3132012093 cites W2117692326 @default.
• W3132012093 cites W2122834552 @default.
• W3132012093 cites W2136850043 @default.
• W3132012093 cites W2146512944 @default.
• W3132012093 cites W2155804510 @default.
• W3132012093 cites W2159675211 @default.
• W3132012093 cites W2161817637 @default.
• W3132012093 cites W2169353806 @default.
• W3132012093 cites W2170956993 @default.
• W3132012093 cites W2321647501 @default.
• W3132012093 cites W2323911351 @default.
• W3132012093 cites W2590180796 @default.
• W3132012093 cites W2735636412 @default.
• W3132012093 cites W2762810610 @default.
• W3132012093 cites W2801693495 @default.
• W3132012093 cites W2900569176 @default.
• W3132012093 cites W2900674638 @default.
• W3132012093 cites W2902348364 @default.
• W3132012093 cites W2903384460 @default.
• W3132012093 cites W2917612467 @default.
• W3132012093 cites W2925287488 @default.
• W3132012093 cites W2954785163 @default.
• W3132012093 cites W2960027376 @default.
• W3132012093 cites W2969802526 @default.
• W3132012093 cites W2976277286 @default.
• W3132012093 cites W2980163489 @default.
• W3132012093 cites W3000080936 @default.
• W3132012093 cites W3000207214 @default.
• W3132012093 cites W3091945274 @default.
• W3132012093 cites W4232620598 @default.
• W3132012093 doi "https://doi.org/10.3389/fonc.2020.613102" @default.
• W3132012093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7907500" @default.
• W3132012093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33643914" @default.
• W3132012093 hasPublicationYear "2021" @default.
• W3132012093 type Work @default.
• W3132012093 sameAs 3132012093 @default.
• W3132012093 citedByCount "6" @default.
• W3132012093 countsByYear W31320120932021 @default.
• W3132012093 countsByYear W31320120932022 @default.
• W3132012093 countsByYear W31320120932023 @default.
• W3132012093 crossrefType "journal-article" @default.
• W3132012093 hasAuthorship W3132012093A5010458663 @default.
• W3132012093 hasAuthorship W3132012093A5014120734 @default.
• W3132012093 hasAuthorship W3132012093A5014191568 @default.
• W3132012093 hasAuthorship W3132012093A5015716870 @default.
• W3132012093 hasAuthorship W3132012093A5026946651 @default.
• W3132012093 hasAuthorship W3132012093A5062051935 @default.
• W3132012093 hasAuthorship W3132012093A5088638269 @default.
• W3132012093 hasBestOaLocation W31320120931 @default.
• W3132012093 hasConcept C104317684 @default.
• W3132012093 hasConcept C105795698 @default.
• W3132012093 hasConcept C126322002 @default.
• W3132012093 hasConcept C143998085 @default.
• W3132012093 hasConcept C144301174 @default.
• W3132012093 hasConcept C161584116 @default.
• W3132012093 hasConcept C199163554 @default.
• W3132012093 hasConcept C2778019345 @default.
• W3132012093 hasConcept C33923547 @default.
• W3132012093 hasConcept C34626388 @default.
• W3132012093 hasConcept C38180746 @default.
• W3132012093 hasConcept C41282012 @default.
• W3132012093 hasConcept C50382708 @default.
• W3132012093 hasConcept C55493867 @default.
• W3132012093 hasConcept C67705224 @default.
• W3132012093 hasConcept C71924100 @default.
• W3132012093 hasConcept C86803240 @default.
• W3132012093 hasConceptScore W3132012093C104317684 @default.
• W3132012093 hasConceptScore W3132012093C105795698 @default.
• W3132012093 hasConceptScore W3132012093C126322002 @default.
• W3132012093 hasConceptScore W3132012093C143998085 @default.
• W3132012093 hasConceptScore W3132012093C144301174 @default.
• W3132012093 hasConceptScore W3132012093C161584116 @default.
• W3132012093 hasConceptScore W3132012093C199163554 @default.
• W3132012093 hasConceptScore W3132012093C2778019345 @default.
• W3132012093 hasConceptScore W3132012093C33923547 @default.
• W3132012093 hasConceptScore W3132012093C34626388 @default.
• W3132012093 hasConceptScore W3132012093C38180746 @default.
• W3132012093 hasConceptScore W3132012093C41282012 @default.
• W3132012093 hasConceptScore W3132012093C50382708 @default.

• next