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- W3132017404 abstract "Vascular abnormalities are a hallmark of most solid tumors including NSCLC and facilitate immune evasion. Nintedanib is oral multitarget angiokinase inhibitor, and in combination with docetaxel is an important and effective second-line treatment option for locally advanced, metastatic or locally recurrent NSCLC of adenocarcinoma tumor histology with the maximum benefit in patients who progressed within 9 months after start of first-line treatment or with progressive disease as best response to first-line chemotherapy. However, immunotherapy is now playing the main role. Recent studies showed the potential clinical benefit of nintedanib plus docetaxel in patients who failed prior immune checkpoint inhibitor. Besides nintedanib with docetaxel should be the preferred choice of a second-line treatment after platinum-based doublet chemotherapy in case of early progression, low level or negative expression of PD-L1, concomitant use of steroids." @default.
- W3132017404 created "2021-03-01" @default.
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- W3132017404 date "2019-11-22" @default.
- W3132017404 modified "2023-09-24" @default.
- W3132017404 title "Antiangiogenic therapy of advanced non-squamous non-small cell lung cancer in era of immuno-oncology: role, place and optimization of treatment approaches" @default.
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- W3132017404 doi "https://doi.org/10.33667/2078-5631-2019-3-28(403)-18-24" @default.
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