FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132075680> ?p ?o ?g. }

• W3132075680 abstract "One new aporphine, dicentrine-β-N-oxide (1), together with five related known alkaloids dehydrodicentrine (2), predicentrine (3), N-methyllaurotetanine (4), cassythicine (5), and dicentrine (6) were isolated from the leaves of Ocotea puberula (Lauraceae). Antiprotozoal activity of the isolated compounds was evaluated in vitro against trypomastigote forms of Trypanosoma cruzi. Among the tested compounds, alkaloid 1 exhibited higher potential with EC50 value of 18.2 μM and reduced toxicity against NCTC cells (CC50>200 μM – SI>11.0), similar to positive control benznidazole (EC50 of 17.7 μM and SI=10.7). Considering the promising results of dicentrine-β-N-oxide (1) against trypomastigotes, the mechanism of parasite death caused by this alkaloid was investigated. As observed, this compound reached the plasma membrane electric potential directly after 2 h of incubation and triggered mitochondrial depolarization, which probably leads to trypomastigote death. Therefore, dicentrine-β-N-oxide (1), reported for the first time in this work, can contribute to future works for the development of new trypanocidal agents." @default.
• W3132075680 created "2021-03-01" @default.
• W3132075680 creator A5008833161 @default.
• W3132075680 creator A5013388360 @default.
• W3132075680 creator A5016258179 @default.
• W3132075680 creator A5021139108 @default.
• W3132075680 creator A5033551689 @default.
• W3132075680 creator A5037968243 @default.
• W3132075680 creator A5039265931 @default.
• W3132075680 creator A5070734904 @default.
• W3132075680 creator A5075274613 @default.
• W3132075680 creator A5082931819 @default.
• W3132075680 date "2021-03-01" @default.
• W3132075680 modified "2023-10-18" @default.
• W3132075680 title "Aporphine Alkaloids from <i>Ocotea puberula</i> with Anti‐ <i>Trypanosoma Cruzi</i> Potential – Activity of Dicentrine‐β‐ <i>N</i> ‐Oxide in the Plasma Membrane Electric Potentials" @default.
• W3132075680 cites W1493835226 @default.
• W3132075680 cites W1772829880 @default.
• W3132075680 cites W1983595846 @default.
• W3132075680 cites W2002746961 @default.
• W3132075680 cites W2007060537 @default.
• W3132075680 cites W2008091140 @default.
• W3132075680 cites W2015300191 @default.
• W3132075680 cites W2026314724 @default.
• W3132075680 cites W2028791900 @default.
• W3132075680 cites W2030299761 @default.
• W3132075680 cites W2032754817 @default.
• W3132075680 cites W2037328302 @default.
• W3132075680 cites W2040615565 @default.
• W3132075680 cites W2044356003 @default.
• W3132075680 cites W2050042093 @default.
• W3132075680 cites W2050282059 @default.
• W3132075680 cites W2065432726 @default.
• W3132075680 cites W2072101316 @default.
• W3132075680 cites W2088687100 @default.
• W3132075680 cites W2092023218 @default.
• W3132075680 cites W2104645257 @default.
• W3132075680 cites W2145367956 @default.
• W3132075680 cites W2147460950 @default.
• W3132075680 cites W2148103881 @default.
• W3132075680 cites W2317366094 @default.
• W3132075680 cites W2318262213 @default.
• W3132075680 cites W2328397252 @default.
• W3132075680 cites W2763660888 @default.
• W3132075680 cites W2939367718 @default.
• W3132075680 cites W2942741556 @default.
• W3132075680 cites W2990483612 @default.
• W3132075680 cites W2994717461 @default.
• W3132075680 cites W3011366455 @default.
• W3132075680 cites W3033764597 @default.
• W3132075680 cites W403781288 @default.
• W3132075680 cites W4239568869 @default.
• W3132075680 doi "https://doi.org/10.1002/cbdv.202001022" @default.
• W3132075680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33635585" @default.
• W3132075680 hasPublicationYear "2021" @default.
• W3132075680 type Work @default.
• W3132075680 sameAs 3132075680 @default.
• W3132075680 citedByCount "3" @default.
• W3132075680 countsByYear W31320756802022 @default.
• W3132075680 countsByYear W31320756802023 @default.
• W3132075680 crossrefType "journal-article" @default.
• W3132075680 hasAuthorship W3132075680A5008833161 @default.
• W3132075680 hasAuthorship W3132075680A5013388360 @default.
• W3132075680 hasAuthorship W3132075680A5016258179 @default.
• W3132075680 hasAuthorship W3132075680A5021139108 @default.
• W3132075680 hasAuthorship W3132075680A5033551689 @default.
• W3132075680 hasAuthorship W3132075680A5037968243 @default.
• W3132075680 hasAuthorship W3132075680A5039265931 @default.
• W3132075680 hasAuthorship W3132075680A5070734904 @default.
• W3132075680 hasAuthorship W3132075680A5075274613 @default.
• W3132075680 hasAuthorship W3132075680A5082931819 @default.
• W3132075680 hasConcept C12554922 @default.
• W3132075680 hasConcept C136764020 @default.
• W3132075680 hasConcept C185592680 @default.
• W3132075680 hasConcept C202751555 @default.
• W3132075680 hasConcept C2776171842 @default.
• W3132075680 hasConcept C2777625466 @default.
• W3132075680 hasConcept C2777667214 @default.
• W3132075680 hasConcept C2778079118 @default.
• W3132075680 hasConcept C2778625465 @default.
• W3132075680 hasConcept C41008148 @default.
• W3132075680 hasConcept C4141045 @default.
• W3132075680 hasConcept C55493867 @default.
• W3132075680 hasConcept C59822182 @default.
• W3132075680 hasConcept C71240020 @default.
• W3132075680 hasConcept C71928629 @default.
• W3132075680 hasConcept C86803240 @default.
• W3132075680 hasConcept C96529984 @default.
• W3132075680 hasConceptScore W3132075680C12554922 @default.
• W3132075680 hasConceptScore W3132075680C136764020 @default.
• W3132075680 hasConceptScore W3132075680C185592680 @default.
• W3132075680 hasConceptScore W3132075680C202751555 @default.
• W3132075680 hasConceptScore W3132075680C2776171842 @default.
• W3132075680 hasConceptScore W3132075680C2777625466 @default.
• W3132075680 hasConceptScore W3132075680C2777667214 @default.
• W3132075680 hasConceptScore W3132075680C2778079118 @default.
• W3132075680 hasConceptScore W3132075680C2778625465 @default.
• W3132075680 hasConceptScore W3132075680C41008148 @default.
• W3132075680 hasConceptScore W3132075680C4141045 @default.
• W3132075680 hasConceptScore W3132075680C55493867 @default.
• W3132075680 hasConceptScore W3132075680C59822182 @default.

• next