Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132093483> ?p ?o ?g. }
- W3132093483 endingPage "1870" @default.
- W3132093483 startingPage "1861" @default.
- W3132093483 abstract "Abstract In the vast majority of cases, glomerular filtration rate (GFR) is estimated using serum creatinine, which is highly influenced by age, sex, muscle mass, body composition, severe chronic illness and many other factors. This often leads to misclassification of patients or potentially puts patients at risk for inappropriate clinical decisions. Possible solutions are the use of cystatin C as an alternative endogenous marker or performing direct measurement of GFR using an exogenous marker such as iohexol. The purpose of this review is to highlight clinical scenarios and conditions such as extreme body composition, Black race, disagreement between creatinine- and cystatin C–based estimated GFR (eGFR), drug dosing, liver cirrhosis, advanced chronic kidney disease and the transition to kidney replacement therapy, non-kidney solid organ transplant recipients and living kidney donors where creatinine-based GFR estimation may be invalid. In contrast to the majority of literature on measured GFR (mGFR), this review does not include aspects of mGFR for research or public health settings but aims to reach practicing clinicians and raise their understanding of the substantial limitations of creatinine. While including cystatin C as a renal biomarker in GFR estimating equations has been shown to increase the accuracy of the GFR estimate, there are also limitations to eGFR based on cystatin C alone or the combination of creatinine and cystatin C in the clinical scenarios described above that can be overcome by measuring GFR with an exogenous marker. We acknowledge that mGFR is not readily available in many centres but hope that this review will highlight and promote the expansion of kidney function diagnostics using standardized mGFR procedures as an important milestone towards more accurate and personalized medicine." @default.
- W3132093483 created "2021-03-01" @default.
- W3132093483 creator A5013305242 @default.
- W3132093483 creator A5031580643 @default.
- W3132093483 creator A5037203909 @default.
- W3132093483 creator A5037597028 @default.
- W3132093483 creator A5043090203 @default.
- W3132093483 creator A5046569845 @default.
- W3132093483 creator A5059227599 @default.
- W3132093483 creator A5060577916 @default.
- W3132093483 creator A5073579980 @default.
- W3132093483 creator A5080291040 @default.
- W3132093483 creator A5086132292 @default.
- W3132093483 creator A5087776349 @default.
- W3132093483 creator A5091846684 @default.
- W3132093483 date "2021-02-22" @default.
- W3132093483 modified "2023-10-13" @default.
- W3132093483 title "Assessment of kidney function: clinical indications for measured GFR" @default.
- W3132093483 cites W1480965731 @default.
- W3132093483 cites W1550111394 @default.
- W3132093483 cites W1773156881 @default.
- W3132093483 cites W1832098425 @default.
- W3132093483 cites W1867440651 @default.
- W3132093483 cites W1920547475 @default.
- W3132093483 cites W1966462384 @default.
- W3132093483 cites W1972440844 @default.
- W3132093483 cites W1982428643 @default.
- W3132093483 cites W1987388617 @default.
- W3132093483 cites W1988039564 @default.
- W3132093483 cites W1989860515 @default.
- W3132093483 cites W1994112911 @default.
- W3132093483 cites W2008905653 @default.
- W3132093483 cites W2010520337 @default.
- W3132093483 cites W2015607415 @default.
- W3132093483 cites W2017389988 @default.
- W3132093483 cites W2024335572 @default.
- W3132093483 cites W2029439479 @default.
- W3132093483 cites W2038730677 @default.
- W3132093483 cites W2046393754 @default.
- W3132093483 cites W2050851526 @default.
- W3132093483 cites W2053601215 @default.
- W3132093483 cites W2055864845 @default.
- W3132093483 cites W2059692241 @default.
- W3132093483 cites W2063240381 @default.
- W3132093483 cites W2066220235 @default.
- W3132093483 cites W2068718128 @default.
- W3132093483 cites W2075057933 @default.
- W3132093483 cites W2079416423 @default.
- W3132093483 cites W2080381604 @default.
- W3132093483 cites W2084020470 @default.
- W3132093483 cites W2088238946 @default.
- W3132093483 cites W2088646036 @default.
- W3132093483 cites W2089814424 @default.
- W3132093483 cites W2091680374 @default.
- W3132093483 cites W2093470872 @default.
- W3132093483 cites W2096423612 @default.
- W3132093483 cites W2098025063 @default.
- W3132093483 cites W2098987087 @default.
- W3132093483 cites W2099531681 @default.
- W3132093483 cites W2100757193 @default.
- W3132093483 cites W2105121012 @default.
- W3132093483 cites W2108670430 @default.
- W3132093483 cites W2109290349 @default.
- W3132093483 cites W2111767923 @default.
- W3132093483 cites W2113525844 @default.
- W3132093483 cites W2116996913 @default.
- W3132093483 cites W2118625269 @default.
- W3132093483 cites W2119160857 @default.
- W3132093483 cites W2119284279 @default.
- W3132093483 cites W2123655973 @default.
- W3132093483 cites W2125924337 @default.
- W3132093483 cites W2145886426 @default.
- W3132093483 cites W2147928550 @default.
- W3132093483 cites W2148032390 @default.
- W3132093483 cites W2152843986 @default.
- W3132093483 cites W2155965977 @default.
- W3132093483 cites W2156398152 @default.
- W3132093483 cites W2156486561 @default.
- W3132093483 cites W2171223411 @default.
- W3132093483 cites W2172000846 @default.
- W3132093483 cites W2193661310 @default.
- W3132093483 cites W2206849760 @default.
- W3132093483 cites W2269022859 @default.
- W3132093483 cites W2317301101 @default.
- W3132093483 cites W2321909854 @default.
- W3132093483 cites W2321925611 @default.
- W3132093483 cites W2377313522 @default.
- W3132093483 cites W2402005785 @default.
- W3132093483 cites W2517255048 @default.
- W3132093483 cites W2534956713 @default.
- W3132093483 cites W2556511787 @default.
- W3132093483 cites W2561950437 @default.
- W3132093483 cites W2586372027 @default.
- W3132093483 cites W2595446086 @default.
- W3132093483 cites W2599677725 @default.
- W3132093483 cites W2601858507 @default.
- W3132093483 cites W2620865376 @default.
- W3132093483 cites W2739262366 @default.