Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132100036> ?p ?o ?g. }
- W3132100036 endingPage "1356" @default.
- W3132100036 startingPage "1343" @default.
- W3132100036 abstract "Piezo1 forms a mechanically activated calcium-permeable nonselective cation channel that is functionally important in many cell types. Structural data exist for C-terminal regions, but we lack information about N-terminal regions and how the entire channel interacts with the lipid bilayer. Here, we use computational approaches to predict the three-dimensional structure of the full-length Piezo1 and simulate it in an asymmetric membrane. A number of novel insights are suggested by the model: 1) Piezo1 creates a trilobed dome in the membrane that extends beyond the radius of the protein, 2) Piezo1 changes the lipid environment in its vicinity via preferential interactions with cholesterol and phosphatidylinositol 4,5-bisphosphate (PIP2) molecules, and 3) cholesterol changes the depth of the dome and PIP2 binding preference. In vitro alteration of cholesterol concentration inhibits Piezo1 activity in a manner complementing some of our computational findings. The data suggest the importance of N-terminal regions of Piezo1 for dome structure and membrane cholesterol and PIP2 interactions." @default.
- W3132100036 created "2021-03-01" @default.
- W3132100036 creator A5012284811 @default.
- W3132100036 creator A5024901095 @default.
- W3132100036 creator A5027312074 @default.
- W3132100036 creator A5031616336 @default.
- W3132100036 creator A5036019223 @default.
- W3132100036 creator A5061099924 @default.
- W3132100036 creator A5064518084 @default.
- W3132100036 creator A5068112587 @default.
- W3132100036 date "2021-04-01" @default.
- W3132100036 modified "2023-10-16" @default.
- W3132100036 title "Modeling of full-length Piezo1 suggests importance of the proximal N-terminus for dome structure" @default.
- W3132100036 cites W1031578623 @default.
- W3132100036 cites W1521591940 @default.
- W3132100036 cites W1526447302 @default.
- W3132100036 cites W1928745964 @default.
- W3132100036 cites W1973724314 @default.
- W3132100036 cites W1979709047 @default.
- W3132100036 cites W1980374511 @default.
- W3132100036 cites W1983897833 @default.
- W3132100036 cites W1989979419 @default.
- W3132100036 cites W1990815583 @default.
- W3132100036 cites W1991643569 @default.
- W3132100036 cites W1994215475 @default.
- W3132100036 cites W1995435834 @default.
- W3132100036 cites W1999613945 @default.
- W3132100036 cites W2034566079 @default.
- W3132100036 cites W2035266068 @default.
- W3132100036 cites W2040438591 @default.
- W3132100036 cites W2044832274 @default.
- W3132100036 cites W2052027527 @default.
- W3132100036 cites W2057477511 @default.
- W3132100036 cites W2064746504 @default.
- W3132100036 cites W2065283382 @default.
- W3132100036 cites W2072167784 @default.
- W3132100036 cites W2072917759 @default.
- W3132100036 cites W2080709055 @default.
- W3132100036 cites W2081693079 @default.
- W3132100036 cites W2082179247 @default.
- W3132100036 cites W2092526634 @default.
- W3132100036 cites W2094458603 @default.
- W3132100036 cites W2094909794 @default.
- W3132100036 cites W2101762911 @default.
- W3132100036 cites W2104989250 @default.
- W3132100036 cites W2105275058 @default.
- W3132100036 cites W2112153736 @default.
- W3132100036 cites W2113018006 @default.
- W3132100036 cites W2113755495 @default.
- W3132100036 cites W2121516676 @default.
- W3132100036 cites W2132629607 @default.
- W3132100036 cites W2134577432 @default.
- W3132100036 cites W2142142115 @default.
- W3132100036 cites W2149079172 @default.
- W3132100036 cites W2153187042 @default.
- W3132100036 cites W2171517688 @default.
- W3132100036 cites W2178135303 @default.
- W3132100036 cites W2193068214 @default.
- W3132100036 cites W2194585050 @default.
- W3132100036 cites W2252707930 @default.
- W3132100036 cites W2256087259 @default.
- W3132100036 cites W2260991120 @default.
- W3132100036 cites W2272911234 @default.
- W3132100036 cites W2301678655 @default.
- W3132100036 cites W2314292783 @default.
- W3132100036 cites W2322467581 @default.
- W3132100036 cites W2327174080 @default.
- W3132100036 cites W2335823606 @default.
- W3132100036 cites W2528566479 @default.
- W3132100036 cites W2530833951 @default.
- W3132100036 cites W2555705980 @default.
- W3132100036 cites W2560380241 @default.
- W3132100036 cites W2584847871 @default.
- W3132100036 cites W2611792444 @default.
- W3132100036 cites W2747918806 @default.
- W3132100036 cites W2769558023 @default.
- W3132100036 cites W2774142732 @default.
- W3132100036 cites W2779962245 @default.
- W3132100036 cites W2890020800 @default.
- W3132100036 cites W2902875048 @default.
- W3132100036 cites W2903035331 @default.
- W3132100036 cites W2903534151 @default.
- W3132100036 cites W2911421449 @default.
- W3132100036 cites W2921245417 @default.
- W3132100036 cites W2941112903 @default.
- W3132100036 cites W2968420254 @default.
- W3132100036 cites W2969551943 @default.
- W3132100036 cites W2969725318 @default.
- W3132100036 cites W2969829558 @default.
- W3132100036 cites W2973598194 @default.
- W3132100036 cites W2978100335 @default.
- W3132100036 cites W2979879484 @default.
- W3132100036 cites W3017074454 @default.
- W3132100036 cites W3026969263 @default.
- W3132100036 cites W3036575374 @default.
- W3132100036 cites W3037395564 @default.
- W3132100036 cites W3081570112 @default.
- W3132100036 cites W4239340399 @default.