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- W3132103665 abstract "Objective: Several reports have proposed that lncRNAs, as potential biomarkers, participate in the progression and growth ofmalignant tumors. HIF1A-AS2 is a novel lncRNA and potential biomarker, involved in the genesis and development of carcinomas.However, the molecular mechanism of HIF1A-AS2 in renal carcinoma is unclear. Methods: The relative expression levels of HIF1A-AS2 and miR-30a-5p were detected using RT-qPCR in renal carcinoma tissuesand cell lines. Using loss-of-function and overexpression, the biological effects of HIF1A-AS2 and miR-30a-5p in kidney carcinomaprogression were characterized. Dual luciferase reporter gene analysis and Western blot were used to detect the potential mechanismof HIF1A-AS2 in renal carcinomas. Results: HIF1A-AS2 was upregulated in kidney carcinoma tissues when compared with para-carcinoma tissues (P < 0.05). Inaddition, tumor size, tumor node mestastasis stage and differentiation were identified as being closely associated with HIF1A-AS2expression (P < 0.05). Knockdown or overexpression of HIF1A-AS2 either restrained or promoted the malignant phenotype andWNT/β-catenin signaling in renal carcinoma cells (P < 0.05). MiR-30a-5p was downregulated in renal cancers and partially reversedHIF1A-AS2 functions in malignant renal tumor cells. HIF1A-AS2 acted as a microRNA sponge that actively regulated the relativeexpression of SOX4 in sponging miR-30a-5p and subsequently increased the malignant phenotypes of renal carcinomas. HIF1A-AS2showed a carcinogenic effect and miR-30a-5p acted as an antagonist of the anti-oncogene effects in the pathogenesis of renalcarcinomas. Conclusions: The HIF1A-AS2-miR-30a-5p-SOX4 axis was associated with the malignant progression and development of renalcarcinoma. The relative expression of HIF1A-AS2 was negatively correlated with the expression of miR-30a-5p, and was closelycorrelated with SOX4 mRNA levels in renal cancers." @default.
- W3132103665 created "2021-03-01" @default.
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- W3132103665 date "2021-01-01" @default.
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- W3132103665 title "LncRNA HIF1A-AS2 accelerates malignant phenotypes of renal carcinoma by modulating miR-30a-5p/SOX4 axis as a ceRNA" @default.
- W3132103665 doi "https://doi.org/10.20892/j.issn.2095-3941.2020.0209" @default.
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