FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132118255> ?p ?o ?g. }

• W3132118255 endingPage "100874" @default.
• W3132118255 startingPage "100874" @default.
• W3132118255 abstract "Infertility is a reproductive health problem that affects 13%–18% of couples in the human population. Genetic factors contributing to infertility are a major cause of concern in couples seeking assisted reproductive techniques. Testis-expressed gene 11 ( TEX11 ) is an X-linked gene responsible for a number of genetic infertility cases. Screening and identification of most deleterious non-synonymous SNPs (nsSNPs) in the human TEX11 gene associated with male infertility via various sequence and structural bioinformatics tools. A systematic insilico analysis was performed using pathogenicity prediction tools including SIFT, PolyPhen, PROVEAN, PHDSNP, and MutPred to identify the damaging nsSNPs of TEX11 . Protein stability changes were observed with I Mutant and MuPro. Molecular modeling and insilico site-directed mutagenesis approaches were used to build the wild type and mutant TEX11 protein models. Next through molecular dynamics simulations of TEX11 WT and TEX11 MT proteins were performed to assess important structural modifications and stability behavior. Detailed computational analysis predicted seven nsSNPs of TEX11 as highly damaging (Y275C, L329P, F365C, W637R, L677R, L677P, and D734Y) by all pathogenicity prediction tools. All these mutations showed to decrease protein stability and may contribute to dissociating the molecular interactions. Present comprehensive computational analysis confirms the pathogenicity of infertility associated TEX11 variants which could be used as a genetic diagnostic marker for future therapeutics measures. • This study was undertaken to identify the deleteriouns nsSNPs of human TEX11 gene involved in male infertility • Detailed in silico analysis predicted seven nsSNPs of TEX11 as highly damaging (Y275C, L329P, F365C, W637R, L677R, L677P, and D734Y) • The predicted variants may prove useful for diagnostic purpose as genetic markers for male infertility" @default.
• W3132118255 created "2021-03-01" @default.
• W3132118255 creator A5019682373 @default.
• W3132118255 creator A5049770908 @default.
• W3132118255 creator A5054014050 @default.
• W3132118255 creator A5081801819 @default.
• W3132118255 date "2021-06-01" @default.
• W3132118255 modified "2023-09-27" @default.
• W3132118255 title "Computational screening of pathogenic non-synonymous SNPs of the human TEX11 gene and their structural and functional consequences" @default.
• W3132118255 cites W1031578623 @default.
• W3132118255 cites W1499944371 @default.
• W3132118255 cites W1504401263 @default.
• W3132118255 cites W1969717780 @default.
• W3132118255 cites W1971938921 @default.
• W3132118255 cites W1975459052 @default.
• W3132118255 cites W1998634450 @default.
• W3132118255 cites W2033579939 @default.
• W3132118255 cites W2035687084 @default.
• W3132118255 cites W2049602967 @default.
• W3132118255 cites W2069337540 @default.
• W3132118255 cites W2091916394 @default.
• W3132118255 cites W2102668767 @default.
• W3132118255 cites W2107301924 @default.
• W3132118255 cites W2121519777 @default.
• W3132118255 cites W2126468827 @default.
• W3132118255 cites W2127439007 @default.
• W3132118255 cites W2131581447 @default.
• W3132118255 cites W2132629607 @default.
• W3132118255 cites W2136513422 @default.
• W3132118255 cites W2151183252 @default.
• W3132118255 cites W2158899309 @default.
• W3132118255 cites W2803269156 @default.
• W3132118255 cites W3087451599 @default.
• W3132118255 cites W327137974 @default.
• W3132118255 cites W4253030196 @default.
• W3132118255 doi "https://doi.org/10.1016/j.mgene.2021.100874" @default.
• W3132118255 hasPublicationYear "2021" @default.
• W3132118255 type Work @default.
• W3132118255 sameAs 3132118255 @default.
• W3132118255 citedByCount "1" @default.
• W3132118255 countsByYear W31321182552023 @default.
• W3132118255 crossrefType "journal-article" @default.
• W3132118255 hasAuthorship W3132118255A5019682373 @default.
• W3132118255 hasAuthorship W3132118255A5049770908 @default.
• W3132118255 hasAuthorship W3132118255A5054014050 @default.
• W3132118255 hasAuthorship W3132118255A5081801819 @default.
• W3132118255 hasConcept C104317684 @default.
• W3132118255 hasConcept C135763542 @default.
• W3132118255 hasConcept C153209595 @default.
• W3132118255 hasConcept C54355233 @default.
• W3132118255 hasConcept C70721500 @default.
• W3132118255 hasConcept C86803240 @default.
• W3132118255 hasConceptScore W3132118255C104317684 @default.
• W3132118255 hasConceptScore W3132118255C135763542 @default.
• W3132118255 hasConceptScore W3132118255C153209595 @default.
• W3132118255 hasConceptScore W3132118255C54355233 @default.
• W3132118255 hasConceptScore W3132118255C70721500 @default.
• W3132118255 hasConceptScore W3132118255C86803240 @default.
• W3132118255 hasLocation W31321182551 @default.
• W3132118255 hasOpenAccess W3132118255 @default.
• W3132118255 hasPrimaryLocation W31321182551 @default.
• W3132118255 hasRelatedWork W1984103522 @default.
• W3132118255 hasRelatedWork W1991523530 @default.
• W3132118255 hasRelatedWork W2002128513 @default.
• W3132118255 hasRelatedWork W2014074135 @default.
• W3132118255 hasRelatedWork W2020824267 @default.
• W3132118255 hasRelatedWork W2031436818 @default.
• W3132118255 hasRelatedWork W2075354549 @default.
• W3132118255 hasRelatedWork W2119103177 @default.
• W3132118255 hasRelatedWork W2171277769 @default.
• W3132118255 hasRelatedWork W2092874662 @default.
• W3132118255 hasVolume "28" @default.
• W3132118255 isParatext "false" @default.
• W3132118255 isRetracted "false" @default.
• W3132118255 magId "3132118255" @default.
• W3132118255 workType "article" @default.