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• W3132126917 abstract "Human zona pellucida (ZP) matrix is composed of four glycoproteins designated as ZP glycoprotein -1 (ZP1), -2 (ZP2), -3 (ZP3), and -4 (ZP4). Mutations in the genes encoding human ZP glycoproteins are one of the causative factors leading to abnormal ZP matrix and infertility in women. Relevance of the human ZP glycoproteins in ‘sperm–oocyte’ binding has been delineated by using either transgenic animal models expressing human zona proteins or purified native/recombinant human zona proteins. Studies based on the purified native/recombinant human zona proteins revealed that ZP1, ZP3, and ZP4 primarily bind to the capacitated acrosome-intact human spermatozoa whereas ZP2 binds to acrosome-reacted spermatozoa. On the contrary, human spermatozoa binds to the eggs obtained from transgenic mouse lines expressing human ZP2 but not to those expressing human ZP1, ZP3, and ZP4 suggesting that ZP2 has an important role in human ‘sperm–oocyte’ binding. Further studies using transgenic mouse lines showed that the N-terminus of human ZP2 mediate the taxon-specific human sperm–oocyte binding. Both glycans and protein-protein interactions have a role in human gamete interaction. Further studies have revealed that the purified native/recombinant human ZP1, ZP3, and ZP4 are competent to induce acrosome reaction. Human sperm binds to the mouse transgenic eggs expressing human ZP1-4 instead of mouse ZP1-3 proteins, penetrated the ZP matrix and accumulated in the perivitelline space, which were acrosome-reacted suggesting that human ZP2 in transgenic mouse model also induce acrosome reaction. In humans N -linked glycosylation of zona proteins have been shown to play an important role in induction of the acrosome reaction. Hence in humans, based on studies using transgenic mouse model as well as purified native/recombinant zona proteins, it is likely that more than one zona protein is involved in the ‘sperm–oocyte’ binding and induction of the acrosome reaction." @default.
• W3132126917 created "2021-03-01" @default.
• W3132126917 creator A5077996251 @default.
• W3132126917 date "2021-02-11" @default.
• W3132126917 modified "2023-10-13" @default.
• W3132126917 title "Human Zona Pellucida Glycoproteins: Binding Characteristics With Human Spermatozoa and Induction of Acrosome Reaction" @default.
• W3132126917 cites W1616509154 @default.
• W3132126917 cites W1794113482 @default.
• W3132126917 cites W1963715731 @default.
• W3132126917 cites W1968067554 @default.
• W3132126917 cites W1968290970 @default.
• W3132126917 cites W1970973021 @default.
• W3132126917 cites W1977082455 @default.
• W3132126917 cites W1977297266 @default.
• W3132126917 cites W1978587695 @default.
• W3132126917 cites W1980118313 @default.
• W3132126917 cites W1981898395 @default.
• W3132126917 cites W1989626072 @default.
• W3132126917 cites W1990593359 @default.
• W3132126917 cites W1993059461 @default.
• W3132126917 cites W2002504846 @default.
• W3132126917 cites W2005038934 @default.
• W3132126917 cites W2005520822 @default.
• W3132126917 cites W2008084413 @default.
• W3132126917 cites W2008881740 @default.
• W3132126917 cites W2019456930 @default.
• W3132126917 cites W2026486120 @default.
• W3132126917 cites W2027906358 @default.
• W3132126917 cites W2029171490 @default.
• W3132126917 cites W2029586927 @default.
• W3132126917 cites W2034819522 @default.
• W3132126917 cites W2036224430 @default.
• W3132126917 cites W2040418931 @default.
• W3132126917 cites W2050255768 @default.
• W3132126917 cites W2053921943 @default.
• W3132126917 cites W2055918259 @default.
• W3132126917 cites W2056274976 @default.
• W3132126917 cites W2062173578 @default.
• W3132126917 cites W2063608213 @default.
• W3132126917 cites W2065296043 @default.
• W3132126917 cites W2070754177 @default.
• W3132126917 cites W2071348291 @default.
• W3132126917 cites W2077345744 @default.
• W3132126917 cites W2079194758 @default.
• W3132126917 cites W2082789073 @default.
• W3132126917 cites W2082827470 @default.
• W3132126917 cites W2084857735 @default.
• W3132126917 cites W2085216282 @default.
• W3132126917 cites W2089097517 @default.
• W3132126917 cites W2091099401 @default.
• W3132126917 cites W2092195265 @default.
• W3132126917 cites W2098169015 @default.
• W3132126917 cites W2100577383 @default.
• W3132126917 cites W2102969883 @default.
• W3132126917 cites W2102973468 @default.
• W3132126917 cites W2104449835 @default.
• W3132126917 cites W2109177107 @default.
• W3132126917 cites W2110456656 @default.
• W3132126917 cites W2110762398 @default.
• W3132126917 cites W2123244447 @default.
• W3132126917 cites W2126596396 @default.
• W3132126917 cites W2127176880 @default.
• W3132126917 cites W2130583664 @default.
• W3132126917 cites W2136069515 @default.
• W3132126917 cites W2138080570 @default.
• W3132126917 cites W2140372422 @default.
• W3132126917 cites W2141372545 @default.
• W3132126917 cites W2141492781 @default.
• W3132126917 cites W2141731481 @default.
• W3132126917 cites W2149353919 @default.
• W3132126917 cites W2149563114 @default.
• W3132126917 cites W2150077769 @default.
• W3132126917 cites W2153578796 @default.
• W3132126917 cites W2157080555 @default.
• W3132126917 cites W2157920066 @default.
• W3132126917 cites W2158795116 @default.
• W3132126917 cites W2163116586 @default.
• W3132126917 cites W2167019883 @default.
• W3132126917 cites W2168301890 @default.
• W3132126917 cites W2170323001 @default.
• W3132126917 cites W2286444875 @default.
• W3132126917 cites W2344601317 @default.
• W3132126917 cites W2589065883 @default.
• W3132126917 cites W2618576980 @default.
• W3132126917 cites W2640706551 @default.
• W3132126917 cites W2753536711 @default.
• W3132126917 cites W2792364159 @default.
• W3132126917 cites W2794555508 @default.
• W3132126917 cites W2800846715 @default.
• W3132126917 cites W2807711110 @default.
• W3132126917 cites W2886250188 @default.
• W3132126917 cites W2916229347 @default.
• W3132126917 cites W2957321430 @default.
• W3132126917 cites W2960886004 @default.
• W3132126917 cites W2980775094 @default.
• W3132126917 doi "https://doi.org/10.3389/fcell.2021.619868" @default.
• W3132126917 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7928326" @default.
• W3132126917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33681199" @default.
• W3132126917 hasPublicationYear "2021" @default.
• W3132126917 type Work @default.

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