Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132138075> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W3132138075 abstract "ADAMTS members have been implicated in vascular diseases by degrading extracellular matrix (ECM), but their functional significance in vascular development remains unknown. We now show that the secreted protease ADAMTS18 is produced by mesenchymal cells and fibroblasts surrounding the embryonic aortic arch (AOAR) and the common carotid artery (CCA). ADAMTS18 deficiency leads to aberrant AOAR and CCA, which further disturbs the development of the 3rd and 4th branchial arch appendages, leading to lack of formation of the carotid body, generation of ectopic and hypoplastic thymus, and variation of intracranial vascular branches of CCA. ADAMTS18 was shown to modulate the ECM abundance around AOAR and CCA, in particular fibronectin (Fn). Adamts18 deficiency lead to Fn accumulation, thus activating the Notch3 signaling pathway to promote the differentiation of cranial neural crest cells (CNCCs) to vascular smooth muscle cells. These data disclose that ADAMTS18-mediated ECM homeostasis is crucial for the differentiation of CNCCs." @default.
- W3132138075 created "2021-03-01" @default.
- W3132138075 creator A5005463689 @default.
- W3132138075 creator A5043059211 @default.
- W3132138075 creator A5045814399 @default.
- W3132138075 creator A5052615768 @default.
- W3132138075 creator A5056091982 @default.
- W3132138075 creator A5059798037 @default.
- W3132138075 creator A5060656369 @default.
- W3132138075 creator A5068381320 @default.
- W3132138075 creator A5073847344 @default.
- W3132138075 creator A5079815759 @default.
- W3132138075 creator A5080402486 @default.
- W3132138075 date "2021-01-01" @default.
- W3132138075 modified "2023-09-23" @default.
- W3132138075 title "ADAMTS18 Modulates the Development of Aortic Arch and Common Carotid Artery" @default.
- W3132138075 doi "https://doi.org/10.2139/ssrn.3780285" @default.
- W3132138075 hasPublicationYear "2021" @default.
- W3132138075 type Work @default.
- W3132138075 sameAs 3132138075 @default.
- W3132138075 citedByCount "0" @default.
- W3132138075 crossrefType "journal-article" @default.
- W3132138075 hasAuthorship W3132138075A5005463689 @default.
- W3132138075 hasAuthorship W3132138075A5043059211 @default.
- W3132138075 hasAuthorship W3132138075A5045814399 @default.
- W3132138075 hasAuthorship W3132138075A5052615768 @default.
- W3132138075 hasAuthorship W3132138075A5056091982 @default.
- W3132138075 hasAuthorship W3132138075A5059798037 @default.
- W3132138075 hasAuthorship W3132138075A5060656369 @default.
- W3132138075 hasAuthorship W3132138075A5068381320 @default.
- W3132138075 hasAuthorship W3132138075A5073847344 @default.
- W3132138075 hasAuthorship W3132138075A5079815759 @default.
- W3132138075 hasAuthorship W3132138075A5080402486 @default.
- W3132138075 hasConcept C126749454 @default.
- W3132138075 hasConcept C189165786 @default.
- W3132138075 hasConcept C196843134 @default.
- W3132138075 hasConcept C86492073 @default.
- W3132138075 hasConcept C86803240 @default.
- W3132138075 hasConcept C95444343 @default.
- W3132138075 hasConceptScore W3132138075C126749454 @default.
- W3132138075 hasConceptScore W3132138075C189165786 @default.
- W3132138075 hasConceptScore W3132138075C196843134 @default.
- W3132138075 hasConceptScore W3132138075C86492073 @default.
- W3132138075 hasConceptScore W3132138075C86803240 @default.
- W3132138075 hasConceptScore W3132138075C95444343 @default.
- W3132138075 hasLocation W31321380751 @default.
- W3132138075 hasOpenAccess W3132138075 @default.
- W3132138075 hasPrimaryLocation W31321380751 @default.
- W3132138075 hasRelatedWork W10430741 @default.
- W3132138075 hasRelatedWork W13055029 @default.
- W3132138075 hasRelatedWork W16126408 @default.
- W3132138075 hasRelatedWork W1674676 @default.
- W3132138075 hasRelatedWork W25119454 @default.
- W3132138075 hasRelatedWork W28933028 @default.
- W3132138075 hasRelatedWork W34051461 @default.
- W3132138075 hasRelatedWork W3459498 @default.
- W3132138075 hasRelatedWork W35569930 @default.
- W3132138075 hasRelatedWork W35992532 @default.
- W3132138075 isParatext "false" @default.
- W3132138075 isRetracted "false" @default.
- W3132138075 magId "3132138075" @default.
- W3132138075 workType "article" @default.