FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132151011> ?p ?o ?g. }

• W3132151011 endingPage "1328" @default.
• W3132151011 startingPage "1316" @default.
• W3132151011 abstract "Abstract Background Neuropathic pain is a complex condition characterized by sensory, cognitive and affective symptoms that magnify the perception of pain. The underlying pathogenic mechanisms are largely unknown and there is an urgent need for the development of novel medications. The endocannabinoid system modulates pain perception and drugs targeting the cannabinoid receptor type 2 (CB2) devoid of psychoactive side effects could emerge as novel analgesics. An interesting model to evaluate the mechanisms underlying resistance to pain is the fragile X mental retardation protein knockout mouse (Fmr1KO), a model of fragile X syndrome that exhibits nociceptive deficits and fails to develop neuropathic pain. Methods A partial sciatic nerve ligation was performed to wild‐type (WT) and Fmr1KO mice having (HzCB2 and Fmr1KO‐HzCB2, respectively) or not (WT and Fmr1KO mice) a partial deletion of CB2 to investigate the participation of the endocannabinoid system on the pain‐resistant phenotype of Fmr1KO mice. Results Nerve injury induced canonical hypersensitivity in WT and HzCB2 mice, whereas this increased pain sensitivity was absent in Fmr1KO mice. Interestingly, Fmr1KO mice partially lacking CB2 lost this protection against neuropathic pain. Similarly, pain‐induced depressive‐like behaviour was observed in WT, HzCB2 and Fmr1KO‐HzCB2 mice, but not in Fmr1KO littermates. Nerve injury evoked different alterations in WT and Fmr1KO mice at spinal and supra‐spinal levels that correlated with these nociceptive and emotional alterations. Conclusions This work shows that CB2 is necessary for the protection against neuropathic pain observed in Fmr1KO mice, raising the interest in targeting this receptor for the treatment of neuropathic pain. Significance Neuropathic pain is a complex chronic pain condition and current treatments are limited by the lack of efficacy and the incidence of important side effects. Our findings show that the pain‐resistant phenotype of Fmr1KO mice against nociceptive and emotional manifestations triggered by persistent nerve damage requires the participation of the cannabinoid receptor CB2, raising the interest in targeting this receptor for neuropathic pain treatment. Additional multidisciplinary studies more closely related to human pain experience should be conducted to explore the potential use of cannabinoids as adequate analgesic tools." @default.
• W3132151011 created "2021-03-01" @default.
• W3132151011 creator A5005470954 @default.
• W3132151011 creator A5020006084 @default.
• W3132151011 creator A5023380523 @default.
• W3132151011 creator A5063994483 @default.
• W3132151011 creator A5072435665 @default.
• W3132151011 creator A5084206957 @default.
• W3132151011 date "2021-03-08" @default.
• W3132151011 modified "2023-10-02" @default.
• W3132151011 title "Role of the endocannabinoid system in a mouse model of Fragile X undergoing neuropathic pain" @default.
• W3132151011 cites W1838128250 @default.
• W3132151011 cites W1970749696 @default.
• W3132151011 cites W1974744093 @default.
• W3132151011 cites W1975585602 @default.
• W3132151011 cites W2006926570 @default.
• W3132151011 cites W2014007136 @default.
• W3132151011 cites W2018388760 @default.
• W3132151011 cites W2034746288 @default.
• W3132151011 cites W2035605437 @default.
• W3132151011 cites W2038338205 @default.
• W3132151011 cites W2044659508 @default.
• W3132151011 cites W2061301719 @default.
• W3132151011 cites W2062830657 @default.
• W3132151011 cites W2064457703 @default.
• W3132151011 cites W2064925871 @default.
• W3132151011 cites W2068185361 @default.
• W3132151011 cites W2105302541 @default.
• W3132151011 cites W2107277218 @default.
• W3132151011 cites W2136408513 @default.
• W3132151011 cites W2145062794 @default.
• W3132151011 cites W2152139376 @default.
• W3132151011 cites W2154834572 @default.
• W3132151011 cites W2172201406 @default.
• W3132151011 cites W2264211366 @default.
• W3132151011 cites W2295932321 @default.
• W3132151011 cites W2314259872 @default.
• W3132151011 cites W2415246453 @default.
• W3132151011 cites W2513701981 @default.
• W3132151011 cites W2520744785 @default.
• W3132151011 cites W2527039926 @default.
• W3132151011 cites W2552622568 @default.
• W3132151011 cites W2569704946 @default.
• W3132151011 cites W2600178581 @default.
• W3132151011 cites W2616514543 @default.
• W3132151011 cites W2749153132 @default.
• W3132151011 cites W2752069735 @default.
• W3132151011 cites W2765113723 @default.
• W3132151011 cites W2774541884 @default.
• W3132151011 cites W2782429951 @default.
• W3132151011 cites W2884378175 @default.
• W3132151011 cites W2885751347 @default.
• W3132151011 cites W2886046928 @default.
• W3132151011 cites W2891765584 @default.
• W3132151011 cites W2906590066 @default.
• W3132151011 cites W2906886777 @default.
• W3132151011 cites W2981882335 @default.
• W3132151011 cites W3023254428 @default.
• W3132151011 cites W3037971984 @default.
• W3132151011 cites W3046137259 @default.
• W3132151011 cites W4211119836 @default.
• W3132151011 doi "https://doi.org/10.1002/ejp.1753" @default.
• W3132151011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33619843" @default.
• W3132151011 hasPublicationYear "2021" @default.
• W3132151011 type Work @default.
• W3132151011 sameAs 3132151011 @default.
• W3132151011 citedByCount "7" @default.
• W3132151011 countsByYear W31321510112021 @default.
• W3132151011 countsByYear W31321510112022 @default.
• W3132151011 countsByYear W31321510112023 @default.
• W3132151011 crossrefType "journal-article" @default.
• W3132151011 hasAuthorship W3132151011A5005470954 @default.
• W3132151011 hasAuthorship W3132151011A5020006084 @default.
• W3132151011 hasAuthorship W3132151011A5023380523 @default.
• W3132151011 hasAuthorship W3132151011A5063994483 @default.
• W3132151011 hasAuthorship W3132151011A5072435665 @default.
• W3132151011 hasAuthorship W3132151011A5084206957 @default.
• W3132151011 hasBestOaLocation W31321510112 @default.
• W3132151011 hasConcept C126322002 @default.
• W3132151011 hasConcept C148001335 @default.
• W3132151011 hasConcept C15490471 @default.
• W3132151011 hasConcept C15744967 @default.
• W3132151011 hasConcept C169760540 @default.
• W3132151011 hasConcept C170493617 @default.
• W3132151011 hasConcept C2775991916 @default.
• W3132151011 hasConcept C2777107010 @default.
• W3132151011 hasConcept C2778938600 @default.
• W3132151011 hasConcept C2780871563 @default.
• W3132151011 hasConcept C2781149210 @default.
• W3132151011 hasConcept C42219234 @default.
• W3132151011 hasConcept C46721173 @default.
• W3132151011 hasConcept C71924100 @default.
• W3132151011 hasConcept C93248783 @default.
• W3132151011 hasConceptScore W3132151011C126322002 @default.
• W3132151011 hasConceptScore W3132151011C148001335 @default.
• W3132151011 hasConceptScore W3132151011C15490471 @default.
• W3132151011 hasConceptScore W3132151011C15744967 @default.
• W3132151011 hasConceptScore W3132151011C169760540 @default.

• next