FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132151251> ?p ?o ?g. }

• W3132151251 endingPage "R713" @default.
• W3132151251 startingPage "R704" @default.
• W3132151251 abstract "The Tibetan chicken ( Gallus gallus; TBC) is an indigenous breed found in the Qinghai-Tibet Plateau that are well adapted to a hypoxic environment. The energy metabolism of embryonic brains in TBCs under hypoxia has been little reported. This study investigated changes in energy metabolism of the TBC brain during embryo development under hypoxia. We found that TBCs exhibited a change of glycolysis and the tricarboxylic acid cycle during embryo development under hypoxia. Hypoxia-inducible factor (HIF)-1 was potentially involved in this by directly inducing overexpression of pyruvate dehydrogenase kinase 1 ( PDK1) and the glycolytic genes hexokinase 1 ( HK1) and lactate dehydrogenase A ( LDHA) to increase glycolysis of TBCs to adapt to hypoxia. Although these may not be unique to TBCs, as we had also found similar results in Dwarf Laying Chickens, a lowland chicken breed, TBCs had a stronger regulating ability. In summary, our study revealed that HIF-1 induced energy metabolism changes in the TBC brain via upregulating expressions of PDK1 and other HIF-1 target genes like HK1 and LDHA to increase glycolysis for TBC hypoxic adaptations during embryo development. It indicates the potential application of TBC energy metabolism research for other animals living on the Qinghai-Tibet Plateau." @default.
• W3132151251 created "2021-03-01" @default.
• W3132151251 creator A5020993784 @default.
• W3132151251 creator A5024924117 @default.
• W3132151251 creator A5033626807 @default.
• W3132151251 creator A5049341927 @default.
• W3132151251 creator A5073288930 @default.
• W3132151251 creator A5073492416 @default.
• W3132151251 creator A5074627981 @default.
• W3132151251 date "2021-05-01" @default.
• W3132151251 modified "2023-10-18" @default.
• W3132151251 title "HIF-1 regulates energy metabolism of the Tibetan chicken brain during embryo development under hypoxia" @default.
• W3132151251 cites W1583486645 @default.
• W3132151251 cites W1982449224 @default.
• W3132151251 cites W1984060145 @default.
• W3132151251 cites W1985458442 @default.
• W3132151251 cites W1989048472 @default.
• W3132151251 cites W1998664010 @default.
• W3132151251 cites W2010394923 @default.
• W3132151251 cites W2012245441 @default.
• W3132151251 cites W2021741218 @default.
• W3132151251 cites W2027705428 @default.
• W3132151251 cites W2033958147 @default.
• W3132151251 cites W2035983112 @default.
• W3132151251 cites W2038009564 @default.
• W3132151251 cites W2053291546 @default.
• W3132151251 cites W2056158543 @default.
• W3132151251 cites W2074824347 @default.
• W3132151251 cites W2077688090 @default.
• W3132151251 cites W2078118869 @default.
• W3132151251 cites W2078489806 @default.
• W3132151251 cites W2098861504 @default.
• W3132151251 cites W2098972920 @default.
• W3132151251 cites W2101084498 @default.
• W3132151251 cites W2102526923 @default.
• W3132151251 cites W2109492293 @default.
• W3132151251 cites W2112337731 @default.
• W3132151251 cites W2121248812 @default.
• W3132151251 cites W2121437466 @default.
• W3132151251 cites W2125724189 @default.
• W3132151251 cites W2135836641 @default.
• W3132151251 cites W2140034535 @default.
• W3132151251 cites W2143343444 @default.
• W3132151251 cites W2152701395 @default.
• W3132151251 cites W2158196806 @default.
• W3132151251 cites W2163069245 @default.
• W3132151251 cites W2171627387 @default.
• W3132151251 cites W2172654775 @default.
• W3132151251 cites W2228720667 @default.
• W3132151251 cites W2291309867 @default.
• W3132151251 cites W2321482338 @default.
• W3132151251 cites W2323751465 @default.
• W3132151251 cites W2915070117 @default.
• W3132151251 cites W3128849265 @default.
• W3132151251 cites W4294718043 @default.
• W3132151251 doi "https://doi.org/10.1152/ajpregu.00052.2020" @default.
• W3132151251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33596720" @default.
• W3132151251 hasPublicationYear "2021" @default.
• W3132151251 type Work @default.
• W3132151251 sameAs 3132151251 @default.
• W3132151251 citedByCount "5" @default.
• W3132151251 countsByYear W31321512512021 @default.
• W3132151251 countsByYear W31321512512023 @default.
• W3132151251 crossrefType "journal-article" @default.
• W3132151251 hasAuthorship W3132151251A5020993784 @default.
• W3132151251 hasAuthorship W3132151251A5024924117 @default.
• W3132151251 hasAuthorship W3132151251A5033626807 @default.
• W3132151251 hasAuthorship W3132151251A5049341927 @default.
• W3132151251 hasAuthorship W3132151251A5073288930 @default.
• W3132151251 hasAuthorship W3132151251A5073492416 @default.
• W3132151251 hasAuthorship W3132151251A5074627981 @default.
• W3132151251 hasConcept C134018914 @default.
• W3132151251 hasConcept C165135838 @default.
• W3132151251 hasConcept C178790620 @default.
• W3132151251 hasConcept C181199279 @default.
• W3132151251 hasConcept C185592680 @default.
• W3132151251 hasConcept C196843134 @default.
• W3132151251 hasConcept C20251656 @default.
• W3132151251 hasConcept C2777318727 @default.
• W3132151251 hasConcept C2779826832 @default.
• W3132151251 hasConcept C2780854706 @default.
• W3132151251 hasConcept C2910680157 @default.
• W3132151251 hasConcept C540031477 @default.
• W3132151251 hasConcept C55493867 @default.
• W3132151251 hasConcept C62231903 @default.
• W3132151251 hasConcept C7836513 @default.
• W3132151251 hasConcept C86803240 @default.
• W3132151251 hasConcept C87073359 @default.
• W3132151251 hasConcept C95444343 @default.
• W3132151251 hasConceptScore W3132151251C134018914 @default.
• W3132151251 hasConceptScore W3132151251C165135838 @default.
• W3132151251 hasConceptScore W3132151251C178790620 @default.
• W3132151251 hasConceptScore W3132151251C181199279 @default.
• W3132151251 hasConceptScore W3132151251C185592680 @default.
• W3132151251 hasConceptScore W3132151251C196843134 @default.
• W3132151251 hasConceptScore W3132151251C20251656 @default.
• W3132151251 hasConceptScore W3132151251C2777318727 @default.
• W3132151251 hasConceptScore W3132151251C2779826832 @default.

• next