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• W3132154952 abstract "Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a severe respiratory disease with a high mortality of ~ 35%. The lack of approved treatments for MERS-CoV infection underscores the need for a user-friendly system for rapid drug screening. In this study, we constructed a MERS-CoV replicon containing the Renilla luciferase (Rluc) reporter gene and a stable luciferase replicon-carrying cell line. Using this cell line, we showed that MERS-CoV replication was inhibited by combined application of lopinavir and ritonavir, indicating that this cell line can be used to screen inhibitors of MERS-CoV replication. Importantly, the MERS-replicon cell line can be used for high-throughput screening of antiviral drugs without the need for live virus handling, providing an effective and safe tool for the discovery of antiviral drugs against MERS-CoV." @default.
• W3132154952 created "2021-03-01" @default.
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• W3132154952 date "2021-02-22" @default.
• W3132154952 modified "2023-10-06" @default.
• W3132154952 title "Development of A MERS-CoV Replicon Cell Line for Antiviral Screening" @default.
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• W3132154952 doi "https://doi.org/10.1007/s12250-020-00341-z" @default.
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