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- W3132155087 abstract "Significance Chronic pain is one of the most pressing national healthcare problems, and as a result, chronic pain was named by the NIH as the “silent epidemic.” Consequentially, chronic pain has directly contributed to the disproportionate increase in opioid use in America. However, thus far, there has been little progress in discovery of alternative noninvasive therapeutics for chronic pain. The current report outlines the repurposing of three tetracyclines for treatment of neuropathic pain by targeting the catalytic domain of EphB1 kinase. These results can be readily applicable clinically for treatment of neuropathic pain and provide proof of concept for the development of molecules for targeting Eph/ephrin-mediated pathologies." @default.
- W3132155087 created "2021-03-01" @default.
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- W3132155087 date "2021-02-24" @default.
- W3132155087 modified "2023-10-05" @default.
- W3132155087 title "Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain" @default.
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- W3132155087 doi "https://doi.org/10.1073/pnas.2016265118" @default.
- W3132155087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7958374" @default.
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- W3132155087 hasPublicationYear "2021" @default.
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