FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132172325> ?p ?o ?g. }

• W3132172325 abstract "Type 2 diabetes (T2D) is a heterogeneous disease with well-known genetic and environmental risk factors contributing to its prevalence. Epigenetic mechanisms related to changes in DNA methylation (DNAm), may also contribute to T2D risk, but larger studies are required to discover novel markers, and to confirm existing ones.We performed a large meta-analysis of individual epigenome-wide association studies (EWAS) of prevalent T2D conducted in four European studies using peripheral blood DNAm. Analysis of differentially methylated regions (DMR) was also undertaken, based on the meta-analysis results. We found three novel CpGs associated with prevalent T2D in Europeans at cg00144180 (HDAC4), cg16765088 (near SYNM) and cg24704287 (near MIR23A) and confirmed three CpGs previously identified (mapping to TXNIP, ABCG1 and CPT1A). We also identified 77 T2D associated DMRs, most of them hypomethylated in T2D cases versus controls. In adjusted regressions among diabetic-free participants in ALSPAC, we found that all six CpGs identified in the meta-EWAS were associated with white cell-types. We estimated that these six CpGs captured 11% of the variation in T2D, which was similar to the variation explained by the model including only the common risk factors of BMI, sex, age and smoking (R2 = 10.6%).This study identifies novel loci associated with T2D in Europeans. We also demonstrate associations of the same loci with other traits. Future studies should investigate if our findings are generalizable in non-European populations, and potential roles of these epigenetic markers in T2D etiology or in determining long term consequences of T2D." @default.
• W3132172325 created "2021-03-01" @default.
• W3132172325 creator A5006966796 @default.
• W3132172325 creator A5011674003 @default.
• W3132172325 creator A5035976303 @default.
• W3132172325 creator A5041997623 @default.
• W3132172325 creator A5042511675 @default.
• W3132172325 creator A5048996236 @default.
• W3132172325 creator A5049892384 @default.
• W3132172325 creator A5054864150 @default.
• W3132172325 creator A5063443876 @default.
• W3132172325 creator A5066436360 @default.
• W3132172325 creator A5077219302 @default.
• W3132172325 date "2021-02-23" @default.
• W3132172325 modified "2023-10-15" @default.
• W3132172325 title "DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts" @default.
• W3132172325 cites W1808248494 @default.
• W3132172325 cites W1855280120 @default.
• W3132172325 cites W1925664165 @default.
• W3132172325 cites W2005421391 @default.
• W3132172325 cites W2022737835 @default.
• W3132172325 cites W2029033394 @default.
• W3132172325 cites W2035284391 @default.
• W3132172325 cites W2042217215 @default.
• W3132172325 cites W2046671000 @default.
• W3132172325 cites W2048581231 @default.
• W3132172325 cites W2077063343 @default.
• W3132172325 cites W2078539102 @default.
• W3132172325 cites W2108730026 @default.
• W3132172325 cites W2116790770 @default.
• W3132172325 cites W2123263006 @default.
• W3132172325 cites W2125477221 @default.
• W3132172325 cites W2129958809 @default.
• W3132172325 cites W2131298552 @default.
• W3132172325 cites W2132289378 @default.
• W3132172325 cites W2133520037 @default.
• W3132172325 cites W2139168999 @default.
• W3132172325 cites W2140575485 @default.
• W3132172325 cites W2143509157 @default.
• W3132172325 cites W2147293213 @default.
• W3132172325 cites W2148749248 @default.
• W3132172325 cites W2153554912 @default.
• W3132172325 cites W2156472431 @default.
• W3132172325 cites W2159422401 @default.
• W3132172325 cites W2162198924 @default.
• W3132172325 cites W2169353806 @default.
• W3132172325 cites W2169556367 @default.
• W3132172325 cites W2184563578 @default.
• W3132172325 cites W2252921808 @default.
• W3132172325 cites W2261451134 @default.
• W3132172325 cites W2279723444 @default.
• W3132172325 cites W2284785012 @default.
• W3132172325 cites W2286048432 @default.
• W3132172325 cites W2316239158 @default.
• W3132172325 cites W2316537321 @default.
• W3132172325 cites W2345328813 @default.
• W3132172325 cites W2346513496 @default.
• W3132172325 cites W2523285199 @default.
• W3132172325 cites W2557027129 @default.
• W3132172325 cites W2560510482 @default.
• W3132172325 cites W2561301122 @default.
• W3132172325 cites W2571274939 @default.
• W3132172325 cites W2583045209 @default.
• W3132172325 cites W2609896442 @default.
• W3132172325 cites W2617316722 @default.
• W3132172325 cites W2766195635 @default.
• W3132172325 cites W2768591422 @default.
• W3132172325 cites W2782975316 @default.
• W3132172325 cites W2783189216 @default.
• W3132172325 cites W2791576088 @default.
• W3132172325 cites W2799758200 @default.
• W3132172325 cites W2807927825 @default.
• W3132172325 cites W2885294207 @default.
• W3132172325 cites W2894662039 @default.
• W3132172325 cites W2902576384 @default.
• W3132172325 cites W2949944742 @default.
• W3132172325 cites W2951674154 @default.
• W3132172325 cites W2951691152 @default.
• W3132172325 cites W2972630199 @default.
• W3132172325 cites W2973820537 @default.
• W3132172325 cites W2987802490 @default.
• W3132172325 cites W2989282004 @default.
• W3132172325 cites W3005085830 @default.
• W3132172325 cites W3009067006 @default.
• W3132172325 cites W3023972366 @default.
• W3132172325 cites W4229839895 @default.
• W3132172325 cites W4240162249 @default.
• W3132172325 cites W4362236767 @default.
• W3132172325 doi "https://doi.org/10.1186/s13148-021-01027-3" @default.
• W3132172325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7903628" @default.
• W3132172325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33622391" @default.
• W3132172325 hasPublicationYear "2021" @default.
• W3132172325 type Work @default.
• W3132172325 sameAs 3132172325 @default.
• W3132172325 citedByCount "34" @default.
• W3132172325 countsByYear W31321723252021 @default.
• W3132172325 countsByYear W31321723252022 @default.
• W3132172325 countsByYear W31321723252023 @default.
• W3132172325 crossrefType "journal-article" @default.
• W3132172325 hasAuthorship W3132172325A5006966796 @default.

• next