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• W3132180801 abstract "There is a marked discrepancy between SARS-CoV-2 seroprevalence and COVID-19 cases and deaths in Africa. SARS-CoV-2 stimulates humoral and cellular immunity systems, as well as mitogen-activated protein kinase (MAPK) and nuclear NF-kB signalling pathways, which regulate inflammatory gene expression and immune cell differentiation. The result is pro-inflammatory cytokines release, hyperinflammatory condition, and cytokine storm, which provoke severe lung alterations that can lead to multi-organ failure in COVID-19. Multiple genetic and immunologic factors may contribute to the severity of COVID-19 in African individuals when compared to the rest of the global population. In this article, the role of malaria, NF-kB and MAPK pathways, caspase-12 expression, high level of LAIR-1-containing antibodies, and differential glycophorins (GYPA/B) expression in COVID-19 are discussed. Understanding pathophysiological mechanisms can help identify target points for drugs and vaccines development against COVID-19. To our knowledge, this is the first study that explores this link and proposes a biological and molecular answer to the epidemiologic discrepancy in COVID-19 in Africa." @default.
• W3132180801 created "2021-03-01" @default.
• W3132180801 creator A5004043577 @default.
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• W3132180801 date "2021-07-01" @default.
• W3132180801 modified "2023-09-29" @default.
• W3132180801 title "Protection against COVID-19 in African population: Immunology, genetics, and malaria clues for therapeutic targets" @default.
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• W3132180801 doi "https://doi.org/10.1016/j.virusres.2021.198347" @default.
• W3132180801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7898966" @default.
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• W3132180801 hasPublicationYear "2021" @default.
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