Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132206989> ?p ?o ?g. }
- W3132206989 abstract "Abstract This study has explored the effect of acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) on Hematopoietic Stem and Progenitor Cell (HSPCs) in mouse bone marrow. Administration of AF-SWCNTs induced a significant decline in the live-cell recovery from bone marrow. Lin-negative Stem cell enriched HSPCs internalized AF-SWCNTs that remained localized in cytoplasmic areas. Incubation of HSPCs with AF-SWCNTs resulted in induction of cell death, inhibition of cell cycle, and induction of reactive oxygen species (ROS) as well as the expression of Caspase 3, 7 and 9 enzymes. In vitro culture with a cytokine cocktail (SCF, GM-CSF, IL3, IL6, IL7) induced differentiation of HSPCs into lymphocytes and myeloid cells, that was inhibited in presence of AF-SWCNTs. Relative recoveries of lymphocytes specifically B lymphocytes, was significantly reduced by AF-SWCNT-treatment, whereas the relative recovery of myeloid cells remained unaltered. These results suggest that AF-SWCNTs have significant toxic effects on HSPCs and differentially suppress the ontogeny of lymphoid and myeloid cells." @default.
- W3132206989 created "2021-03-01" @default.
- W3132206989 creator A5064199359 @default.
- W3132206989 creator A5080593248 @default.
- W3132206989 date "2021-01-01" @default.
- W3132206989 modified "2023-09-24" @default.
- W3132206989 title "Toxicity of poly-dispersed single-walled carbon nanotubes on bone marrow derived Hematopoietic Stem and Progenitor Cells" @default.
- W3132206989 cites W1966176339 @default.
- W3132206989 cites W1973527971 @default.
- W3132206989 cites W1974153392 @default.
- W3132206989 cites W1988179260 @default.
- W3132206989 cites W1992696749 @default.
- W3132206989 cites W2008183439 @default.
- W3132206989 cites W2010265091 @default.
- W3132206989 cites W2013129082 @default.
- W3132206989 cites W2018858346 @default.
- W3132206989 cites W2019985255 @default.
- W3132206989 cites W2025576061 @default.
- W3132206989 cites W2028735719 @default.
- W3132206989 cites W2037796429 @default.
- W3132206989 cites W2047115108 @default.
- W3132206989 cites W2054124980 @default.
- W3132206989 cites W2056868742 @default.
- W3132206989 cites W2056991950 @default.
- W3132206989 cites W2066472222 @default.
- W3132206989 cites W2071040908 @default.
- W3132206989 cites W2088277794 @default.
- W3132206989 cites W2089220360 @default.
- W3132206989 cites W2090950172 @default.
- W3132206989 cites W2117395313 @default.
- W3132206989 cites W2131759199 @default.
- W3132206989 cites W2154699417 @default.
- W3132206989 cites W2168076509 @default.
- W3132206989 cites W2337572018 @default.
- W3132206989 cites W2443004012 @default.
- W3132206989 cites W2466989460 @default.
- W3132206989 cites W2519786994 @default.
- W3132206989 cites W2556561046 @default.
- W3132206989 cites W2588171719 @default.
- W3132206989 cites W2743486778 @default.
- W3132206989 cites W2768469971 @default.
- W3132206989 cites W2906388603 @default.
- W3132206989 cites W2928622732 @default.
- W3132206989 cites W2951130777 @default.
- W3132206989 cites W3001475210 @default.
- W3132206989 cites W3009840110 @default.
- W3132206989 cites W3010479585 @default.
- W3132206989 cites W3013879154 @default.
- W3132206989 cites W3030978338 @default.
- W3132206989 cites W3033273621 @default.
- W3132206989 cites W4236153851 @default.
- W3132206989 doi "https://doi.org/10.1016/j.crtox.2021.02.003" @default.
- W3132206989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8320641" @default.
- W3132206989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34345853" @default.
- W3132206989 hasPublicationYear "2021" @default.
- W3132206989 type Work @default.
- W3132206989 sameAs 3132206989 @default.
- W3132206989 citedByCount "2" @default.
- W3132206989 countsByYear W31322069892021 @default.
- W3132206989 countsByYear W31322069892022 @default.
- W3132206989 crossrefType "journal-article" @default.
- W3132206989 hasAuthorship W3132206989A5064199359 @default.
- W3132206989 hasAuthorship W3132206989A5080593248 @default.
- W3132206989 hasBestOaLocation W31322069891 @default.
- W3132206989 hasConcept C109159458 @default.
- W3132206989 hasConcept C185592680 @default.
- W3132206989 hasConcept C201750760 @default.
- W3132206989 hasConcept C2022786 @default.
- W3132206989 hasConcept C203014093 @default.
- W3132206989 hasConcept C2779282312 @default.
- W3132206989 hasConcept C2780007613 @default.
- W3132206989 hasConcept C28328180 @default.
- W3132206989 hasConcept C86803240 @default.
- W3132206989 hasConcept C95444343 @default.
- W3132206989 hasConceptScore W3132206989C109159458 @default.
- W3132206989 hasConceptScore W3132206989C185592680 @default.
- W3132206989 hasConceptScore W3132206989C201750760 @default.
- W3132206989 hasConceptScore W3132206989C2022786 @default.
- W3132206989 hasConceptScore W3132206989C203014093 @default.
- W3132206989 hasConceptScore W3132206989C2779282312 @default.
- W3132206989 hasConceptScore W3132206989C2780007613 @default.
- W3132206989 hasConceptScore W3132206989C28328180 @default.
- W3132206989 hasConceptScore W3132206989C86803240 @default.
- W3132206989 hasConceptScore W3132206989C95444343 @default.
- W3132206989 hasFunder F4320320719 @default.
- W3132206989 hasLocation W31322069891 @default.
- W3132206989 hasLocation W31322069892 @default.
- W3132206989 hasLocation W31322069893 @default.
- W3132206989 hasOpenAccess W3132206989 @default.
- W3132206989 hasPrimaryLocation W31322069891 @default.
- W3132206989 hasRelatedWork W26477141 @default.
- W3132206989 hasRelatedWork W29377985 @default.
- W3132206989 hasRelatedWork W3477019 @default.
- W3132206989 hasRelatedWork W42360783 @default.
- W3132206989 hasRelatedWork W42461492 @default.
- W3132206989 hasRelatedWork W47434658 @default.
- W3132206989 hasRelatedWork W5208051 @default.
- W3132206989 hasRelatedWork W53286061 @default.
- W3132206989 hasRelatedWork W6595454 @default.
- W3132206989 hasRelatedWork W8963448 @default.