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- W3132234544 abstract "Depending on the solution conditions, complementary G-rich and C-rich strands from the promoter region of the c-MYC oncogene may adopt a range of conformational states including the duplex, G-quadruplex, i-motif, and coil states. In this work, we report data on changes in volume and adiabatic compressibility accompanying G-quadruplex formation by the G-rich strand from the promoter region of the c-MYC oncogene. We also report changes in volume and adiabatic compressibility accompanying duplex formation by the G-rich and C-rich strands which initially are in the coil, G-quadruplex (G-strand), or i-motif (C-strand) states. Our data enable us to unveil a complex interplay between the volumetric properties of the states adopted by the complementary c-MYC promoter strands while also shedding light on the molecular interactions stabilizing each of the partaking conformational states. We discuss the thermodynamic implications of our volumetric data for understanding the conformational behavior of the DNA system under study as a function of the combined effect of temperature and pressure." @default.
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- W3132234544 date "2021-02-01" @default.
- W3132234544 modified "2023-09-27" @default.
- W3132234544 title "Volumetric Interplay between the Conformational States Adopted by DNA Strands from the Promoter Region of the c-MYC Oncogene" @default.
- W3132234544 doi "https://doi.org/10.1016/j.bpj.2020.11.1469" @default.
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