FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132238540> ?p ?o ?g. }

• W3132238540 abstract "SUMMARY Many sensory systems use ribbon-type synapses to transmit their signals to downstream circuits. The properties of this synaptic transfer fundamentally dictate which aspects in the original stimulus will be accentuated or suppressed, thereby partially defining the detection limits of the circuit. Accordingly, sensory neurons have evolved a wide variety of ribbon geometries and vesicle pool properties to best support their diverse functional requirements. However, the need for diverse synaptic functions does not only arise across neuron types, but also within . Here we show that UV-cones, a single type of photoreceptor of the larval zebrafish eye, exhibit striking differences in their synaptic ultrastructure and consequent calcium to glutamate transfer function depending on their location in the eye. We arrive at this conclusion by combining serial section electron microscopy and simultaneous “dual-colour” 2-photon imaging of calcium and glutamate signals from the same synapse in vivo . We further use the functional dataset to fit a cascade-like model of the ribbon synapse with different vesicle pool sizes, transfer rates and other synaptic properties. Exploiting recent developments in simulation-based inference, we obtain full posterior estimates for the parameters and compare these across different retinal regions. The model enables us to extrapolate to new stimuli and to systematically investigate different response behaviours of various ribbon configurations. We also provide an interactive, easy-to-use version of this model as an online tool. Overall, we show that already on the synaptic level of single neuron types there exist highly specialized mechanisms which are advantageous for the encoding of different visual features." @default.
• W3132238540 created "2021-03-01" @default.
• W3132238540 creator A5032509976 @default.
• W3132238540 creator A5043130208 @default.
• W3132238540 creator A5045467405 @default.
• W3132238540 creator A5051315695 @default.
• W3132238540 creator A5080642720 @default.
• W3132238540 date "2021-02-24" @default.
• W3132238540 modified "2023-09-27" @default.
• W3132238540 title "Distinct Synaptic Transfer Functions in Same-Type Photoreceptors" @default.
• W3132238540 cites W100464641 @default.
• W3132238540 cites W1963568591 @default.
• W3132238540 cites W1969031128 @default.
• W3132238540 cites W1972836240 @default.
• W3132238540 cites W1976314836 @default.
• W3132238540 cites W1976637712 @default.
• W3132238540 cites W1979556941 @default.
• W3132238540 cites W1991302410 @default.
• W3132238540 cites W2004047341 @default.
• W3132238540 cites W2015872566 @default.
• W3132238540 cites W2069825770 @default.
• W3132238540 cites W2080723158 @default.
• W3132238540 cites W2089965786 @default.
• W3132238540 cites W2092209687 @default.
• W3132238540 cites W2110128463 @default.
• W3132238540 cites W2122776408 @default.
• W3132238540 cites W2147762902 @default.
• W3132238540 cites W2161304688 @default.
• W3132238540 cites W2161533644 @default.
• W3132238540 cites W2171332611 @default.
• W3132238540 cites W2171946863 @default.
• W3132238540 cites W2212616210 @default.
• W3132238540 cites W2291957660 @default.
• W3132238540 cites W2343653086 @default.
• W3132238540 cites W2582049971 @default.
• W3132238540 cites W2782544897 @default.
• W3132238540 cites W2804982001 @default.
• W3132238540 cites W2949161136 @default.
• W3132238540 cites W2951535823 @default.
• W3132238540 cites W2966372873 @default.
• W3132238540 cites W2969486437 @default.
• W3132238540 cites W2989730456 @default.
• W3132238540 cites W3030370277 @default.
• W3132238540 cites W3044003204 @default.
• W3132238540 cites W3087344693 @default.
• W3132238540 cites W3093509734 @default.
• W3132238540 cites W3112717819 @default.
• W3132238540 cites W3115566009 @default.
• W3132238540 cites W3118674805 @default.
• W3132238540 cites W3127355065 @default.
• W3132238540 cites W3173879018 @default.
• W3132238540 cites W3188931025 @default.
• W3132238540 cites W4231616929 @default.
• W3132238540 hasPublicationYear "2021" @default.
• W3132238540 type Work @default.
• W3132238540 sameAs 3132238540 @default.
• W3132238540 citedByCount "1" @default.
• W3132238540 countsByYear W31322385402020 @default.
• W3132238540 crossrefType "posted-content" @default.
• W3132238540 hasAuthorship W3132238540A5032509976 @default.
• W3132238540 hasAuthorship W3132238540A5043130208 @default.
• W3132238540 hasAuthorship W3132238540A5045467405 @default.
• W3132238540 hasAuthorship W3132238540A5051315695 @default.
• W3132238540 hasAuthorship W3132238540A5080642720 @default.
• W3132238540 hasBestOaLocation W31322385401 @default.
• W3132238540 hasConcept C119599485 @default.
• W3132238540 hasConcept C127413603 @default.
• W3132238540 hasConcept C127445978 @default.
• W3132238540 hasConcept C130316041 @default.
• W3132238540 hasConcept C148785051 @default.
• W3132238540 hasConcept C15744967 @default.
• W3132238540 hasConcept C169760540 @default.
• W3132238540 hasConcept C186060115 @default.
• W3132238540 hasConcept C187102610 @default.
• W3132238540 hasConcept C2779918689 @default.
• W3132238540 hasConcept C38120836 @default.
• W3132238540 hasConcept C41008148 @default.
• W3132238540 hasConcept C41625074 @default.
• W3132238540 hasConcept C542102704 @default.
• W3132238540 hasConcept C54355233 @default.
• W3132238540 hasConcept C81299745 @default.
• W3132238540 hasConcept C86803240 @default.
• W3132238540 hasConcept C94487597 @default.
• W3132238540 hasConceptScore W3132238540C119599485 @default.
• W3132238540 hasConceptScore W3132238540C127413603 @default.
• W3132238540 hasConceptScore W3132238540C127445978 @default.
• W3132238540 hasConceptScore W3132238540C130316041 @default.
• W3132238540 hasConceptScore W3132238540C148785051 @default.
• W3132238540 hasConceptScore W3132238540C15744967 @default.
• W3132238540 hasConceptScore W3132238540C169760540 @default.
• W3132238540 hasConceptScore W3132238540C186060115 @default.
• W3132238540 hasConceptScore W3132238540C187102610 @default.
• W3132238540 hasConceptScore W3132238540C2779918689 @default.
• W3132238540 hasConceptScore W3132238540C38120836 @default.
• W3132238540 hasConceptScore W3132238540C41008148 @default.
• W3132238540 hasConceptScore W3132238540C41625074 @default.
• W3132238540 hasConceptScore W3132238540C542102704 @default.
• W3132238540 hasConceptScore W3132238540C54355233 @default.
• W3132238540 hasConceptScore W3132238540C81299745 @default.
• W3132238540 hasConceptScore W3132238540C86803240 @default.

• next