FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132293720> ?p ?o ?g. }

• W3132293720 endingPage "815" @default.
• W3132293720 startingPage "803" @default.
• W3132293720 abstract "To summarise the available information on efficacy and safety of immunomodulatory agents in SARS-CoV-2 infection.As part of a European League Against Rheumatism (EULAR) taskforce, a systematic literature search was conducted from January 2019 to 11 December 2020. Two reviewers independently identified eligible studies according to the Population, Intervention, Comparator and Outcome framework and extracted data on efficacy and safety of immunomodulatory agents used therapeutically in SARS-CoV-2 infection at any stage. The risk of bias was assessed with validated tools.Of the 60 372 records, 401 articles were eligible for inclusion. Studies were at variable risk of bias. Randomised controlled trials (RCTs) were available for the following drugs: hydroxychloroquine (n=12), glucocorticoids (n=6), tocilizumab (n=4), convalescent plasma (n=4), interferon beta (n=2), intravenous immunoglobulins (IVIg) (n=2) and n=1 each for anakinra, baricitinib, colchicine, leflunomide, ruxolitinib, interferon kappa and vilobelimab. Glucocorticoids were able to reduce mortality in specific subsets of patients, while conflicting data were available about tocilizumab. Hydroxychloroquine was not beneficial at any disease stage, one RCT with anakinra was negative, one RCT with baricitinib+remdesivir was positive, and individual trials on some other compounds provided interesting, although preliminary, results.Although there is emerging evidence about immunomodulatory therapies for the management of COVID-19, conclusive data are scarce with some conflicting data. Since glucocorticoids seem to improve survival in some subsets of patients, RCTs comparing glucocorticoids alone versus glucocorticoids plus anticytokine/immunomodulatory treatment are warranted. This systematic literature review informed the initiative to formulate EULAR 'points to consider' on COVID-19 pathophysiology and immunomodulatory treatment from the rheumatology perspective." @default.
• W3132293720 created "2021-03-01" @default.
• W3132293720 creator A5025055498 @default.
• W3132293720 creator A5051196993 @default.
• W3132293720 creator A5053844235 @default.
• W3132293720 creator A5069190353 @default.
• W3132293720 creator A5071307383 @default.
• W3132293720 creator A5074050010 @default.
• W3132293720 creator A5074519726 @default.
• W3132293720 creator A5077451505 @default.
• W3132293720 date "2021-02-15" @default.
• W3132293720 modified "2023-10-18" @default.
• W3132293720 title "Immunomodulatory therapies for SARS-CoV-2 infection: a systematic literature review to inform EULAR points to consider" @default.
• W3132293720 cites W3009035323 @default.
• W3132293720 cites W3014663601 @default.
• W3132293720 cites W3019062306 @default.
• W3132293720 cites W3025795175 @default.
• W3132293720 cites W3026306769 @default.
• W3132293720 cites W3028706489 @default.
• W3132293720 cites W3030158388 @default.
• W3132293720 cites W3033762686 @default.
• W3132293720 cites W3033871404 @default.
• W3132293720 cites W3034858522 @default.
• W3132293720 cites W3035293132 @default.
• W3132293720 cites W3037701834 @default.
• W3132293720 cites W3037867966 @default.
• W3132293720 cites W3038241707 @default.
• W3132293720 cites W3038423562 @default.
• W3132293720 cites W3043308024 @default.
• W3132293720 cites W3045085017 @default.
• W3132293720 cites W3049278054 @default.
• W3132293720 cites W3081112627 @default.
• W3132293720 cites W3081265795 @default.
• W3132293720 cites W3081721922 @default.
• W3132293720 cites W3081752913 @default.
• W3132293720 cites W3082108964 @default.
• W3132293720 cites W3083863843 @default.
• W3132293720 cites W3084100353 @default.
• W3132293720 cites W3087214787 @default.
• W3132293720 cites W3087360005 @default.
• W3132293720 cites W3087596809 @default.
• W3132293720 cites W3088243710 @default.
• W3132293720 cites W3089416670 @default.
• W3132293720 cites W3089478012 @default.
• W3132293720 cites W3089750907 @default.
• W3132293720 cites W3091501889 @default.
• W3132293720 cites W3091868035 @default.
• W3132293720 cites W3092712522 @default.
• W3132293720 cites W3092855600 @default.
• W3132293720 cites W3093604087 @default.
• W3132293720 cites W3093711492 @default.
• W3132293720 cites W3093837118 @default.
• W3132293720 cites W3093849061 @default.
• W3132293720 cites W3094209984 @default.
• W3132293720 cites W3094452591 @default.
• W3132293720 cites W3094609299 @default.
• W3132293720 cites W3096274861 @default.
• W3132293720 cites W3100405799 @default.
• W3132293720 cites W3100526596 @default.
• W3132293720 cites W3102453076 @default.
• W3132293720 cites W3107151174 @default.
• W3132293720 cites W3108663934 @default.
• W3132293720 cites W3110466220 @default.
• W3132293720 cites W3110844195 @default.
• W3132293720 cites W3119648922 @default.
• W3132293720 cites W3121693389 @default.
• W3132293720 cites W3124292577 @default.
• W3132293720 cites W4205523030 @default.
• W3132293720 cites W4210642183 @default.
• W3132293720 cites W4255364305 @default.
• W3132293720 doi "https://doi.org/10.1136/annrheumdis-2020-219725" @default.
• W3132293720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8142448" @default.
• W3132293720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33589438" @default.
• W3132293720 hasPublicationYear "2021" @default.
• W3132293720 type Work @default.
• W3132293720 sameAs 3132293720 @default.
• W3132293720 citedByCount "27" @default.
• W3132293720 countsByYear W31322937202021 @default.
• W3132293720 countsByYear W31322937202022 @default.
• W3132293720 countsByYear W31322937202023 @default.
• W3132293720 crossrefType "journal-article" @default.
• W3132293720 hasAuthorship W3132293720A5025055498 @default.
• W3132293720 hasAuthorship W3132293720A5051196993 @default.
• W3132293720 hasAuthorship W3132293720A5053844235 @default.
• W3132293720 hasAuthorship W3132293720A5069190353 @default.
• W3132293720 hasAuthorship W3132293720A5071307383 @default.
• W3132293720 hasAuthorship W3132293720A5074050010 @default.
• W3132293720 hasAuthorship W3132293720A5074519726 @default.
• W3132293720 hasAuthorship W3132293720A5077451505 @default.
• W3132293720 hasBestOaLocation W31322937201 @default.
• W3132293720 hasConcept C126322002 @default.
• W3132293720 hasConcept C168563851 @default.
• W3132293720 hasConcept C177713679 @default.
• W3132293720 hasConcept C2777178219 @default.
• W3132293720 hasConcept C2779123688 @default.
• W3132293720 hasConcept C2779134260 @default.
• W3132293720 hasConcept C2781228260 @default.
• W3132293720 hasConcept C2908647359 @default.

• next