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- W3132295617 abstract "Synthetic polycations, such as nylon-3 copolymers, are regarded to be good functional mimics of antimicrobial peptides acting mostly by permeabilizing bacterial membranes. Understanding more complex membrane behavior behind permeabilization, e.g. vesicle aggregation and fusion, has major implications for the better interpretation of different mechanisms of actions. The interactions of two types of nylon-3 copolymers containing different cationic/hydrophobic subunits with zwitterionic or negatively charged vesicles were evaluated. Cryo-electron microscopy visually shows the complex membrane behaviors (i.e. permeabilization, aggregation, and fusion of vesicles) after adding both copolymers. Fluorescence lifetime-based calcein leakage assay was used to characterize the various types of membrane permeabilization. Even more, the fusion process of vesicles was detected by lipid mixing assay (NBD-Rhodamine resonance energy transfer assay) and content mixing assay (ANTS-DPX Assay). Interestingly, the relationship between membrane permeabilization and aggregation or fusion differs for the two nylon-3 copolymers. Both vesicle aggregation and fusion occur often when polycations such as AMPs and their synthetic mimics interact with charged vesicles. The role of vesicle aggregation and fusion in membrane permeabilization is still unclear." @default.
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- W3132295617 date "2021-02-01" @default.
- W3132295617 modified "2023-09-30" @default.
- W3132295617 title "Vesicle Aggregation and Fusion Influence Membrane Permeabilization Induced by Antimicrobial Polycations" @default.
- W3132295617 doi "https://doi.org/10.1016/j.bpj.2020.11.1053" @default.
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