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• W3132304136 abstract "Parkinson's disease (PD) is the second more common neurodegenerative disease with increasing incidence worldwide associated to the population ageing. Despite increasing awareness and significant research advancements, treatment options comprise dopamine repleting, symptomatic therapies that have significantly increased quality of life and life expectancy, but no therapies that halt or reverse disease progression, which remain a great, unmet goal in PD research. Large biomarker development programs are undertaken to identify disease signatures that will improve patient selection and outcome measures in clinical trials. In this review, we summarize PD-related mechanisms that can serve as targets of therapeutic interventions aiming to slow or modify disease progression, as well as previous and ongoing clinical trials in each field, and discuss future perspectives." @default.
• W3132304136 created "2021-03-01" @default.
• W3132304136 creator A5071258074 @default.
• W3132304136 creator A5074190792 @default.
• W3132304136 creator A5083048222 @default.
• W3132304136 date "2021-02-25" @default.
• W3132304136 modified "2023-10-15" @default.
• W3132304136 title "Novel targeted therapies for Parkinson’s disease" @default.
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