FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132314975> ?p ?o ?g. }

• W3132314975 endingPage "887" @default.
• W3132314975 startingPage "887" @default.
• W3132314975 abstract "High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements (double/triple-hit high grade B-cell lymphoma, HGBL-DH/TH) constitutes a provisional entity among B-cell malignancies with an aggressive behavior and dire prognosis. While evidence for the essential prognostic role of the composition of the tumor-microenvironment (TME) in hematologic malignancies is growing, its prognostic impact in HGBL-DH/TH remains unknown. In this study, we outline the adaptive immune response in a cohort of 47 HGBL-DH/TH and 27 triple-negative diffuse large B-cell lymphoma (tnDLBCL) patients in a large-scale, next-generation sequencing (NGS) investigation of the T-cell receptor (TCR) β-chain repertoire and supplement our findings with data on the Glasgow-Prognostic Score (GPS) at diagnosis, as a score-derived measure of systemic inflammation. We supplement these studies with an immunophenotypic investigation of the TME. Our findings demonstrate that the clonal architecture of the TCR repertoire of HGBL-DH/TH differs significantly from tnDLBCL. Moreover, several entity-exclusive clonotypes, suggestive of tumor-neoantigen selection are identified. Additionally, both productive clonality and percentage of maximum frequency clone as measures of TCR repertoire diversity and tumor-directed activity of the adaptive immune system had significant impact on overall survival (OS; productive clonality: p = 0.0273; HR: 2.839; CI: 1.124–7.169; maximum productive frequency: p = 0.0307; HR: 2.167; CI: 1.074–4.370) but not PFS (productive clonality: p = 0.4459; maximum productive frequency: p = 0.5567) in HGBL-DH/TH patients, while GPS was a significant predictor of both OS and PFS (OS: p < 0.0001; PFS: p = 0.0002). Subsequent multivariate analysis revealed GPS and the revised international prognostic index (R-IPI) to be the only prognosticators holding significant impact for OS (GPS: p = 0.038; R-IPI: p = 0.006) and PFS (GPS: p = 0.029; R-IPI: p = 0.006) in HGBL-DH/TH. Through the identification of expanded, recurrent and entity-exclusive TCR-clonotypes we provide indications for a distinct subset of tumor-neoantigenic elements exclusively shared among HGBL-DH/TH. Further, we demonstrate an adverse prognostic role for both systemic inflammation and uniform adaptive immune response." @default.
• W3132314975 created "2021-03-01" @default.
• W3132314975 creator A5001368830 @default.
• W3132314975 creator A5002180825 @default.
• W3132314975 creator A5011725019 @default.
• W3132314975 creator A5014588081 @default.
• W3132314975 creator A5017368964 @default.
• W3132314975 creator A5028056694 @default.
• W3132314975 creator A5042300762 @default.
• W3132314975 creator A5055216320 @default.
• W3132314975 creator A5057918999 @default.
• W3132314975 creator A5066771031 @default.
• W3132314975 creator A5069241167 @default.
• W3132314975 date "2021-02-20" @default.
• W3132314975 modified "2023-10-16" @default.
• W3132314975 title "Systemic Inflammation and Tumour-Infiltrating T-Cell Receptor Repertoire Diversity Are Predictive of Clinical Outcome in High-Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements" @default.
• W3132314975 cites W1632859538 @default.
• W3132314975 cites W1856646401 @default.
• W3132314975 cites W1947079675 @default.
• W3132314975 cites W1966544892 @default.
• W3132314975 cites W1969096316 @default.
• W3132314975 cites W1976564639 @default.
• W3132314975 cites W1978681820 @default.
• W3132314975 cites W1983404060 @default.
• W3132314975 cites W2039123767 @default.
• W3132314975 cites W2043071551 @default.
• W3132314975 cites W2050407789 @default.
• W3132314975 cites W2060354653 @default.
• W3132314975 cites W2072351874 @default.
• W3132314975 cites W2074640340 @default.
• W3132314975 cites W2085276059 @default.
• W3132314975 cites W2089543767 @default.
• W3132314975 cites W2102862705 @default.
• W3132314975 cites W2115919161 @default.
• W3132314975 cites W2141053032 @default.
• W3132314975 cites W2141269240 @default.
• W3132314975 cites W2147246240 @default.
• W3132314975 cites W2148295649 @default.
• W3132314975 cites W2157612047 @default.
• W3132314975 cites W2158267770 @default.
• W3132314975 cites W2159713741 @default.
• W3132314975 cites W2279684443 @default.
• W3132314975 cites W2291298003 @default.
• W3132314975 cites W2310716991 @default.
• W3132314975 cites W2342183967 @default.
• W3132314975 cites W2516172649 @default.
• W3132314975 cites W2518845767 @default.
• W3132314975 cites W2523350566 @default.
• W3132314975 cites W2591946624 @default.
• W3132314975 cites W2610797169 @default.
• W3132314975 cites W2752126733 @default.
• W3132314975 cites W2753952666 @default.
• W3132314975 cites W2803706853 @default.
• W3132314975 cites W2896150319 @default.
• W3132314975 cites W2902375153 @default.
• W3132314975 cites W2963769245 @default.
• W3132314975 cites W2968849363 @default.
• W3132314975 cites W2972566401 @default.
• W3132314975 cites W3007632958 @default.
• W3132314975 cites W3015511442 @default.
• W3132314975 cites W3032800433 @default.
• W3132314975 cites W3087456886 @default.
• W3132314975 cites W3120050808 @default.
• W3132314975 cites W3125460427 @default.
• W3132314975 doi "https://doi.org/10.3390/cancers13040887" @default.
• W3132314975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7924187" @default.
• W3132314975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33672644" @default.
• W3132314975 hasPublicationYear "2021" @default.
• W3132314975 type Work @default.
• W3132314975 sameAs 3132314975 @default.
• W3132314975 citedByCount "5" @default.
• W3132314975 countsByYear W31323149752022 @default.
• W3132314975 countsByYear W31323149752023 @default.
• W3132314975 crossrefType "journal-article" @default.
• W3132314975 hasAuthorship W3132314975A5001368830 @default.
• W3132314975 hasAuthorship W3132314975A5002180825 @default.
• W3132314975 hasAuthorship W3132314975A5011725019 @default.
• W3132314975 hasAuthorship W3132314975A5014588081 @default.
• W3132314975 hasAuthorship W3132314975A5017368964 @default.
• W3132314975 hasAuthorship W3132314975A5028056694 @default.
• W3132314975 hasAuthorship W3132314975A5042300762 @default.
• W3132314975 hasAuthorship W3132314975A5055216320 @default.
• W3132314975 hasAuthorship W3132314975A5057918999 @default.
• W3132314975 hasAuthorship W3132314975A5066771031 @default.
• W3132314975 hasAuthorship W3132314975A5069241167 @default.
• W3132314975 hasBestOaLocation W31323149751 @default.
• W3132314975 hasConcept C104317684 @default.
• W3132314975 hasConcept C126322002 @default.
• W3132314975 hasConcept C143998085 @default.
• W3132314975 hasConcept C159654299 @default.
• W3132314975 hasConcept C19317047 @default.
• W3132314975 hasConcept C203014093 @default.
• W3132314975 hasConcept C2776090121 @default.
• W3132314975 hasConcept C2776107976 @default.
• W3132314975 hasConcept C2777537477 @default.
• W3132314975 hasConcept C2778453870 @default.
• W3132314975 hasConcept C2779338263 @default.
• W3132314975 hasConcept C502942594 @default.

• next