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• W3132318946 abstract "The elevated plus maze test is a widely used test for assessing anxiety-like behavior and screening novel therapeutic agents in rodents. Previous studies have shown that a variety of internal factors and procedural variables can influence elevated plus maze behavior. Although some studies have suggested a link between behavior and plasma corticosterone levels, the relationships between them remain unclear. In this study, we investigated the effects of experience with a battery of behavioral tests, the wall color of the closed arms, and illumination level on the behavior and plasma corticosterone responses in the elevated plus maze in male C57BL/6J mice. Mice were either subjected to a series of behavioral tests, including assessments of general health and neurological function, a light/dark transition test, and an open field test, or left undisturbed until the start of the elevated plus maze test. The mice with and without test battery experience were allowed to freely explore the elevated plus maze. The other two independent groups of naïve mice were tested in mazes with closed arms with different wall colors (clear, transparent blue, white, and black) or different illumination levels (5, 100, and 800 lx). Immediately after the test, blood was collected to measure plasma corticosterone concentrations. Mice with test battery experience showed a lower percentage of open arm time and entries and, somewhat paradoxically, had lower plasma corticosterone levels than the mice with no test battery experience. Mice tested in the maze with closed arms with clear walls exhibited higher open arm exploration than mice tested in the maze with closed arms with black walls, while there were no significant differences in plasma corticosterone levels between the different wall color conditions. Illumination levels had no significant effects on any measure. Our results indicate that experience with other behavioral tests and different physical features of the maze affect elevated plus maze behaviors. Increased open arm time and entries are conventionally interpreted as decreased anxiety-like behavior, while other possible interpretations are considered: open arm exploration may reflect heightened anxiety and panic-like reaction to a novel situation under certain conditions. With the possibility of different interpretations, the present findings highlight the need to carefully consider the test conditions in designing experiments and drawing conclusions from the behavioral outcomes in the elevated plus maze test in C57BL/6J mice." @default.
• W3132318946 created "2021-03-01" @default.
• W3132318946 creator A5038209011 @default.
• W3132318946 creator A5086676643 @default.
• W3132318946 date "2021-02-15" @default.
• W3132318946 modified "2023-09-25" @default.
• W3132318946 title "Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventional interpretation of the test" @default.
• W3132318946 cites W1119193083 @default.
• W3132318946 cites W1529722613 @default.
• W3132318946 cites W1888844103 @default.
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• W3132318946 cites W1963956528 @default.
• W3132318946 cites W1964160578 @default.
• W3132318946 cites W1970176091 @default.
• W3132318946 cites W1974857203 @default.
• W3132318946 cites W1978310063 @default.
• W3132318946 cites W1979784935 @default.
• W3132318946 cites W1980127085 @default.
• W3132318946 cites W1981448374 @default.
• W3132318946 cites W1986748964 @default.
• W3132318946 cites W1986837800 @default.
• W3132318946 cites W1990694352 @default.
• W3132318946 cites W1993280093 @default.
• W3132318946 cites W2002346584 @default.
• W3132318946 cites W2003716127 @default.
• W3132318946 cites W2009823007 @default.
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• W3132318946 cites W2014564827 @default.
• W3132318946 cites W2017638095 @default.
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• W3132318946 cites W2021875927 @default.
• W3132318946 cites W2024875325 @default.
• W3132318946 cites W2025293038 @default.
• W3132318946 cites W2029515700 @default.
• W3132318946 cites W2029880071 @default.
• W3132318946 cites W2029934056 @default.
• W3132318946 cites W2032058764 @default.
• W3132318946 cites W2033332085 @default.
• W3132318946 cites W2035535425 @default.
• W3132318946 cites W2037091931 @default.
• W3132318946 cites W2040395591 @default.
• W3132318946 cites W2040500050 @default.
• W3132318946 cites W2041561931 @default.
• W3132318946 cites W2041879562 @default.
• W3132318946 cites W2045715406 @default.
• W3132318946 cites W2054453564 @default.
• W3132318946 cites W2062105986 @default.
• W3132318946 cites W2065033726 @default.
• W3132318946 cites W2067421324 @default.
• W3132318946 cites W2070368177 @default.
• W3132318946 cites W2079714688 @default.
• W3132318946 cites W2080239815 @default.
• W3132318946 cites W2081750149 @default.
• W3132318946 cites W2085103715 @default.
• W3132318946 cites W2088133485 @default.
• W3132318946 cites W2089680506 @default.
• W3132318946 cites W2095133395 @default.
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• W3132318946 cites W2122880265 @default.
• W3132318946 cites W2130910626 @default.
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• W3132318946 doi "https://doi.org/10.1186/s13041-020-00721-2" @default.
• W3132318946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7885464" @default.
• W3132318946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33588907" @default.
• W3132318946 hasPublicationYear "2021" @default.
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