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Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132386419> ?p ?o ?g. }

• W3132386419 endingPage "1382" @default.
• W3132386419 startingPage "1377" @default.
• W3132386419 abstract "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing more than two million deaths. The SARS-CoV-2 Spike glycoproteins mediate viral entry and represent the main target for antibody responses. Humoral responses were shown to be important for preventing and controlling infection by coronaviruses. A promising approach to reduce the severity of COVID-19 is the transfusion of convalescent plasma. However, longitudinal studies revealed that the level of antibodies targeting the receptor-binding domain (RBD) of the SARS-CoV-2 Spike declines rapidly after the resolution of the infection.To extend this observation beyond the RBD domain, we performed a longitudinal analysis of the persistence of antibodies targeting the full-length SARS-CoV-2 Spike in the plasma from 15 convalescent donors. We generated a 293T cell line constitutively expressing the SARS-CoV-2 Spike and used it to develop a high-throughput flow cytometry-based assay to detect SARS-CoV-2 Spike-specific antibodies in the plasma of convalescent donors.We found that the level of antibodies targeting the full-length SARS-CoV-2 Spike declines gradually after the resolution of the infection. This decline was not related to the number of donations but strongly correlated with the decline of RBD-specific antibodies and the number of days post-symptom onset. These findings help to better understand the decline of humoral responses against the SARS-CoV-2 Spike and provide important information on when to collect plasma after recovery from active infection for convalescent plasma transfusion." @default.
• W3132386419 created "2021-03-01" @default.
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• W3132386419 date "2021-02-18" @default.
• W3132386419 modified "2023-10-03" @default.
• W3132386419 title "High‐throughput detection of antibodies targeting the <scp>SARS‐CoV</scp>‐2 <scp>Spike</scp> in longitudinal convalescent plasma samples" @default.
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• W3132386419 doi "https://doi.org/10.1111/trf.16318" @default.
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• W3132386419 hasPublicationYear "2021" @default.
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