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- W3132424897 abstract "Phaleria macrocarpa (Scheff.) Boerl is a medicinal plant found in Malaysia andIndonesia. This plant has been used traditionally to treat various diseases. Littlestudies have been done to identify compound that contributes to medicinal effect.Moreover, there is lack of studies in the method to extract those valuablecomponents from this plant.This research focuses on the leaves part of the plant. A single compound known asphalerin is targeted and extracted from the leaves. The compound is purified andidentified through chemical analysis such as High Performance LiquidChromatography, Thin Layer Chromatography, Nuclear Magnetic Resonance andLiquid Chromatogram Mass Spectroscopy. Phalerin was tested for the bioactivitystudy including antioxidant, anti-inflammatory and anticancer. Then the extractionprocess using solid-liquid extraction method was investigated on the optimumparameters; solvent, extraction temperature, solid-to-solvent ratio and particle size.Phalerin was proven having antioxidant and anti-inflammatory activity. Water wasthe most suitable solvent for extraction of phalerin from the leaves compared tomethanol, ethanol, ethyl acetate and hexane. Water was not only safe but alsoextracted most of polar compounds. The optimum temperature was at 70°C as toavoid degradation of compound. The optimum solid to solvent ratio was 1:20 (g/ml)as too much solvent leads to waste of solvent and extra energy to remove excessliquid. The smallest particle size (<250 μm) was the optimum size as smallerparticle provide larger surface area for mass transfer.Extraction kinetics on extraction of phalerin found that the process reachequilibrium at 120 min of extraction duration. The first order kinetics model wasapplied and successfully described the extraction process. From thermodynamicstudy, the enthalpy change (ΔH) was found to be positive (72.51 kJ/mol), indicatingthe extraction process of Phaleria macrocarpa leaves is endothermic. The Gibb’sfree energy was found to be negative with values range from -2.75 to -9.95 kJ/mol,indicated the extraction was spontaneous at the operating temperature. Thisspontaneity was favored with increasing extraction temperature. Phalerin is a bioactive compound extracted from Phaleria macrocarpa leaves and having antioxidant and anti-inflammatory activities. Standardization of extract and improvement on the extraction process along with clinical study of phalerin may added new information to this study." @default.
- W3132424897 created "2021-03-01" @default.
- W3132424897 creator A5074173561 @default.
- W3132424897 date "2014-11-01" @default.
- W3132424897 modified "2023-09-27" @default.
- W3132424897 title "Extraction, characterisation, optimisation and modeling of Phalerin from Phaleria Macrocarpa (Scheff.) Boerl leaves" @default.
- W3132424897 hasPublicationYear "2014" @default.
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