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• W3132444906 endingPage "5083" @default.
• W3132444906 startingPage "5076" @default.
• W3132444906 abstract "Abstract The Aptima human papillomavirus (HPV) test (APTIMA) detects E6‐E7 mRNA in abnormal cells in the uterine cervix. To investigate the accuracy of APTIMA for cervical cancer screening in Japan, 423 subjects, mostly referrals with abnormal cytology or being followed up for cervical intraepithelial neoplasia (CIN)1, were screened using two HPV tests, hybrid capture 2 (HC2) and APTIMA, and by the Pap test. Colposcopy was conducted in all subjects with a positive result in either test type. HPV genotyping was performed by Genosearch‐31. A result of atypical squamous cells‐undetermined significance (ASC‐US) or worse on the HC2 test (ASC‐US‐HC2), and low‐grade squamous intraepithelial lesion (LSIL) or worse (LSIL+) on the Pap test, was regarded as positive. APTIMA (97.5%) was more sensitive than LSIL+ (85.1%) for detecting CIN2 or worse (CIN2+) (McNemar test; p = .0003), and more sensitive (98.6%) than ASC‐US‐HC2 (92.7%) for detecting CIN3+. APTIMA and HC2 had similar sensitivities. HPV genotyping revealed that CIN2/3 with high‐risk HPV (HR‐HPV) was overlooked in five cases by ASC‐US‐HC2, and in four cases by HC2, while no such lesions were missed by APTIMA. Thus, APTIMA might be superior to HC2 for primary HPV screening in Japan. One cancer case positive for HPV67 (potentially high risk, [pHR]) was overlooked by Pap test and both HPV tests, suggesting a need for a new HPV test able to detect pHR‐HPV types." @default.
• W3132444906 created "2021-03-01" @default.
• W3132444906 creator A5021999113 @default.
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• W3132444906 date "2021-03-25" @default.
• W3132444906 modified "2023-09-26" @default.
• W3132444906 title "Comparison of Aptima and hybrid capture‐2 HPV tests and Pap test in the referral population in Japan" @default.
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• W3132444906 doi "https://doi.org/10.1002/jmv.26865" @default.
• W3132444906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33634473" @default.
• W3132444906 hasPublicationYear "2021" @default.
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