FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132494145> ?p ?o ?g. }

• W3132494145 endingPage "1717" @default.
• W3132494145 startingPage "1709" @default.
• W3132494145 abstract "Statins are widely used to lower lipids and reduce cardiovascular events. In vitro studies and small studies in patients with hyperlipidemias show statins inhibit tissue factor (TF) and blood coagulation mechanisms. We assessed the effects of simvastatin on TF and coagulation biomarkers in patients entered in STATCOPE, a multicenter, randomized, placebo-controlled trial of simvastatin (40 mg daily) versus placebo on exacerbation rates in patients with chronic obstructive pulmonary disease (COPD).In 227 patients (114 simvastatin, 113 placebo; mean [± standard error of the mean] age 62 ± 0.53 years, 44.5% women) we measured (baseline, and 6 and 12 months): whole blood membrane TF-procoagulant activity (TF-PCA) and plasma factors VIIa, VII, VIII, fibrinogen, TF antigen, tissue factor pathway inhibitor (TFPI), thrombin-antithrombin complexes (TAT), and D-dimer. We excluded patients with diabetes, cardiovascular disease, and those taking or requiring a statin.In the statin group, there was a small increase in TF-PCA (from 25.18 ± 1.08 to 30.36 ± 1.10 U/ml; p = .03) over 12 months; factors VIIa and VIII, fibrinogen, TAT, and D-dimer did not change. Plasma TFPI (from 52.4 ± 1.75 to 44.7 ± 1.78 ng/ml; p < .0001) and FVIIC (1.23 ± 0.04 to 1.15 ± 0.03 U/ml; p = .03) decreased and correlated with total cholesterol levels. No changes in biomarkers were observed with placebo.In contrast to previous studies on statins, in COPD patients without diabetes, cardiovascular disease, or requiring a statin treatment, simvastatin (40 mg per day) did not decrease TF or factors VIIa and VIII, fibrinogen, TAT, or D-dimer. The decreases in TFPI and factor VII reflect the decrease in serum lipids." @default.
• W3132494145 created "2021-03-01" @default.
• W3132494145 creator A5009003396 @default.
• W3132494145 creator A5035213367 @default.
• W3132494145 creator A5051214320 @default.
• W3132494145 creator A5061115846 @default.
• W3132494145 creator A5064360802 @default.
• W3132494145 creator A5074695753 @default.
• W3132494145 creator A5082951448 @default.
• W3132494145 date "2021-07-01" @default.
• W3132494145 modified "2023-10-17" @default.
• W3132494145 title "Effects of simvastatin on tissue factor pathway of blood coagulation in STATCOPE (Simvastatin in the prevention of COPD exacerbations) trial" @default.
• W3132494145 cites W1671726658 @default.
• W3132494145 cites W1689405614 @default.
• W3132494145 cites W1933011991 @default.
• W3132494145 cites W1979746958 @default.
• W3132494145 cites W1991219293 @default.
• W3132494145 cites W1996651828 @default.
• W3132494145 cites W2001712168 @default.
• W3132494145 cites W2002100924 @default.
• W3132494145 cites W2002116384 @default.
• W3132494145 cites W2032251585 @default.
• W3132494145 cites W2044557947 @default.
• W3132494145 cites W2048590478 @default.
• W3132494145 cites W2057799660 @default.
• W3132494145 cites W2065200453 @default.
• W3132494145 cites W2068898353 @default.
• W3132494145 cites W2070635824 @default.
• W3132494145 cites W2071891597 @default.
• W3132494145 cites W2098560324 @default.
• W3132494145 cites W2100858113 @default.
• W3132494145 cites W2106161370 @default.
• W3132494145 cites W2112098540 @default.
• W3132494145 cites W2112459595 @default.
• W3132494145 cites W2120519273 @default.
• W3132494145 cites W2127304691 @default.
• W3132494145 cites W2137983259 @default.
• W3132494145 cites W2141030542 @default.
• W3132494145 cites W2142649232 @default.
• W3132494145 cites W2143976653 @default.
• W3132494145 cites W2147613516 @default.
• W3132494145 cites W2151625183 @default.
• W3132494145 cites W2326560258 @default.
• W3132494145 cites W2486241607 @default.
• W3132494145 cites W2570787279 @default.
• W3132494145 cites W2786262376 @default.
• W3132494145 cites W2896782950 @default.
• W3132494145 cites W2905313402 @default.
• W3132494145 cites W4231307067 @default.
• W3132494145 doi "https://doi.org/10.1111/jth.15282" @default.
• W3132494145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8238804" @default.
• W3132494145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33638931" @default.
• W3132494145 hasPublicationYear "2021" @default.
• W3132494145 type Work @default.
• W3132494145 sameAs 3132494145 @default.
• W3132494145 citedByCount "2" @default.
• W3132494145 countsByYear W31324941452023 @default.
• W3132494145 crossrefType "journal-article" @default.
• W3132494145 hasAuthorship W3132494145A5009003396 @default.
• W3132494145 hasAuthorship W3132494145A5035213367 @default.
• W3132494145 hasAuthorship W3132494145A5051214320 @default.
• W3132494145 hasAuthorship W3132494145A5061115846 @default.
• W3132494145 hasAuthorship W3132494145A5064360802 @default.
• W3132494145 hasAuthorship W3132494145A5074695753 @default.
• W3132494145 hasAuthorship W3132494145A5082951448 @default.
• W3132494145 hasBestOaLocation W31324941451 @default.
• W3132494145 hasConcept C126322002 @default.
• W3132494145 hasConcept C134018914 @default.
• W3132494145 hasConcept C142724271 @default.
• W3132494145 hasConcept C186738567 @default.
• W3132494145 hasConcept C204787440 @default.
• W3132494145 hasConcept C27081682 @default.
• W3132494145 hasConcept C2776329913 @default.
• W3132494145 hasConcept C2776780178 @default.
• W3132494145 hasConcept C2776839432 @default.
• W3132494145 hasConcept C2777151630 @default.
• W3132494145 hasConcept C2778382381 @default.
• W3132494145 hasConcept C2778589496 @default.
• W3132494145 hasConcept C2779036427 @default.
• W3132494145 hasConcept C555293320 @default.
• W3132494145 hasConcept C71924100 @default.
• W3132494145 hasConcept C90924648 @default.
• W3132494145 hasConceptScore W3132494145C126322002 @default.
• W3132494145 hasConceptScore W3132494145C134018914 @default.
• W3132494145 hasConceptScore W3132494145C142724271 @default.
• W3132494145 hasConceptScore W3132494145C186738567 @default.
• W3132494145 hasConceptScore W3132494145C204787440 @default.
• W3132494145 hasConceptScore W3132494145C27081682 @default.
• W3132494145 hasConceptScore W3132494145C2776329913 @default.
• W3132494145 hasConceptScore W3132494145C2776780178 @default.
• W3132494145 hasConceptScore W3132494145C2776839432 @default.
• W3132494145 hasConceptScore W3132494145C2777151630 @default.
• W3132494145 hasConceptScore W3132494145C2778382381 @default.
• W3132494145 hasConceptScore W3132494145C2778589496 @default.
• W3132494145 hasConceptScore W3132494145C2779036427 @default.
• W3132494145 hasConceptScore W3132494145C555293320 @default.
• W3132494145 hasConceptScore W3132494145C71924100 @default.
• W3132494145 hasConceptScore W3132494145C90924648 @default.

• next