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• W3132531504 abstract "In this study active pharmacovigilance was used in an uncontrolled population to enrich the safety profile and canvass the Adverse Drug Reactions (ADRs) associated with the use of a fixed combination of 0.5% timolol + 0.2% brimonidine + 2.0% dorzolamide (TBD).Active pharmacovigilance consisting of 3 follow-up calls within 60 days was used to monitor the product's safety and identify new risks by searching for unexpected ADRs and increased incidence, tolerability, drug interactions and special population-related ADRs.Ninety-four ADRs were reported by a total of 246 patients (0.38 ADRs/patient); all of them were classified as mild. We found an increased risk of ADRs with a Relative Risk (RR) for simultaneous use of TBD + ophthalmic ciprofloxacin and TBD + oral atorvastatin; 2.0309 (95% CI, 1.2467-3.3083) and 1.8864 (95% CI, 1.0543-3.3754), respectively. Two unexpected ADRs were discovered, both of which presented belonged to the System Organ Class (SOC) of infections and infestations and the preferred term (PT) of nasopharyngitis..Three safety signals were identified, two of them corresponded to an increase in the incidence of ADRs and the last one is associated with 2 unexpected ADR. Nevertheless, we found a good tolerability profile for TBD in the study population." @default.
• W3132531504 created "2021-03-01" @default.
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• W3132531504 date "2021-02-01" @default.
• W3132531504 modified "2023-10-18" @default.
• W3132531504 title "Active Pharmacovigilance in Peruvian Population: Surveillance of a Timolol/Brimonidine/Dorzolamide Ophthalmic Fixed Combination" @default.
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• W3132531504 doi "https://doi.org/10.2147/opth.s288180" @default.
• W3132531504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7896785" @default.
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