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• W3132573131 startingPage "1598" @default.
• W3132573131 abstract "Glutamate transporter proteins, expressed on both neurons and glia, serve as the main gatekeepers that dictate the spatial and temporal actions of extracellular glutamate. Glutamate is essential to the function of the healthy brain yet paradoxically contributes to the toxicity associated with many neurodegenerative diseases. Rapid transporter-mediated glutamate uptake, primarily occurring at astrocytic processes, tightens the efficiency of excitatory network activity and prevents toxic glutamate build-up in the extracellular space. Glutamate transporter dysfunction is thought to underlie myriad central nervous system (CNS) diseases including Alzheimer and Huntington disease. Over the past few decades, techniques such as biochemical uptake assays and electrophysiological recordings of transporter currents from individual astrocytes have revealed the remarkable ability of the CNS to efficiently clear extracellular glutamate. In more recent years, the rapidly evolving glutamate-sensing sniffers now allow researchers to visualize real-time glutamate transients on a millisecond time scale with single synapse spatial resolution in defined cell populations. As we transition to an increased reliance on optical-based methods of glutamate visualization and quantification, it is of utmost importance to understand not only the advantages that glutamate biosensors bring to the table but also the associated caveats and their implications for data interpretation. In this review, we summarize the strengths and limitations of the commonly used methods to quantify glutamate uptake. We then discuss what these techniques, when viewed as a complementary whole, have told us about the brain's ability to regulate glutamate levels, in both health and in the context of neurodegenerative disease." @default.
• W3132573131 created "2021-03-01" @default.
• W3132573131 creator A5027419757 @default.
• W3132573131 creator A5035513129 @default.
• W3132573131 creator A5069470898 @default.
• W3132573131 date "2021-02-22" @default.
• W3132573131 modified "2023-10-18" @default.
• W3132573131 title "Entering a new era of quantifying glutamate clearance in health and disease" @default.
• W3132573131 cites W1491108164 @default.
• W3132573131 cites W1532399642 @default.
• W3132573131 cites W1545941184 @default.
• W3132573131 cites W1574724477 @default.
• W3132573131 cites W1644388421 @default.
• W3132573131 cites W1686065874 @default.
• W3132573131 cites W1897919376 @default.
• W3132573131 cites W1900227502 @default.
• W3132573131 cites W1928655587 @default.
• W3132573131 cites W1965044068 @default.
• W3132573131 cites W1965859168 @default.
• W3132573131 cites W1966477142 @default.
• W3132573131 cites W1966556202 @default.
• W3132573131 cites W1966698297 @default.
• W3132573131 cites W1966846060 @default.
• W3132573131 cites W1972161610 @default.
• W3132573131 cites W1972188596 @default.
• W3132573131 cites W1979363543 @default.
• W3132573131 cites W1979889191 @default.
• W3132573131 cites W1980311878 @default.
• W3132573131 cites W1985459796 @default.
• W3132573131 cites W1988278010 @default.
• W3132573131 cites W1988718039 @default.
• W3132573131 cites W1989539506 @default.
• W3132573131 cites W1991806476 @default.
• W3132573131 cites W1997727568 @default.
• W3132573131 cites W2001261203 @default.
• W3132573131 cites W2001618696 @default.
• W3132573131 cites W2002247284 @default.
• W3132573131 cites W2003410399 @default.
• W3132573131 cites W2004156024 @default.
• W3132573131 cites W2004195391 @default.
• W3132573131 cites W2007239691 @default.
• W3132573131 cites W2009812273 @default.
• W3132573131 cites W2012606399 @default.
• W3132573131 cites W2016575029 @default.
• W3132573131 cites W2017349018 @default.
• W3132573131 cites W2017389079 @default.
• W3132573131 cites W2017901987 @default.
• W3132573131 cites W2019784159 @default.
• W3132573131 cites W2025498751 @default.
• W3132573131 cites W2027275070 @default.
• W3132573131 cites W2027582763 @default.
• W3132573131 cites W2028174194 @default.
• W3132573131 cites W2030352252 @default.
• W3132573131 cites W2030641075 @default.
• W3132573131 cites W2035237711 @default.
• W3132573131 cites W2039436205 @default.
• W3132573131 cites W2043001689 @default.
• W3132573131 cites W2044398560 @default.
• W3132573131 cites W2045792432 @default.
• W3132573131 cites W2048916015 @default.
• W3132573131 cites W2050523782 @default.
• W3132573131 cites W2052935486 @default.
• W3132573131 cites W2054197740 @default.
• W3132573131 cites W2063690295 @default.
• W3132573131 cites W2064119008 @default.
• W3132573131 cites W2072623748 @default.
• W3132573131 cites W2073953555 @default.
• W3132573131 cites W2075770826 @default.
• W3132573131 cites W2079185455 @default.
• W3132573131 cites W2081070804 @default.
• W3132573131 cites W2082151254 @default.
• W3132573131 cites W2082180868 @default.
• W3132573131 cites W2082524462 @default.
• W3132573131 cites W2083204774 @default.
• W3132573131 cites W2086915118 @default.
• W3132573131 cites W2091931057 @default.
• W3132573131 cites W2092358916 @default.
• W3132573131 cites W2092939335 @default.
• W3132573131 cites W2099687721 @default.
• W3132573131 cites W2104849634 @default.
• W3132573131 cites W2105832751 @default.
• W3132573131 cites W2108370047 @default.
• W3132573131 cites W2112541356 @default.
• W3132573131 cites W2119883995 @default.
• W3132573131 cites W2120741241 @default.
• W3132573131 cites W2121588319 @default.
• W3132573131 cites W2124603852 @default.
• W3132573131 cites W2126033464 @default.
• W3132573131 cites W2128426029 @default.
• W3132573131 cites W2128744963 @default.
• W3132573131 cites W2129082075 @default.
• W3132573131 cites W2129567809 @default.
• W3132573131 cites W2135573968 @default.
• W3132573131 cites W2141199312 @default.
• W3132573131 cites W2142097068 @default.
• W3132573131 cites W2147372806 @default.
• W3132573131 cites W2147453924 @default.
• W3132573131 cites W2147800368 @default.

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