FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132575616> ?p ?o ?g. }

• W3132575616 endingPage "825" @default.
• W3132575616 startingPage "816" @default.
• W3132575616 abstract "Circular ribonucleic acids (circRNAs) are highly stable and conserved forms of RNAs present in all eukaryotes. They can modulate the expression of genes by sponging specific micro RNAs (miRNAs), thereby affecting various disease processes. However, their expression pattern in human breast cancer has not been elucidated.In this study, differentially expressed circRNAs in breast cancer tissues and paired noncancerous tissues were analyzed using an Arraystar Human circRNA Microarray, and hsa_circ_0006220 was selected for its 27-fold downregulation in breast cancer tissues. Its expression was also verified in 50 breast cancer and paired noncancerous tissues using real-time polymerase chain reaction (RT-PCR). An analysis of the expression of hsa_circ_0006220 and the clinicopathological factors in breast cancer was conducted. A receiver operating characteristic (ROC) curve of hsa_circ_0006220 was constructed. The interaction between hsa_circ_0006220 and five possible target miRNAs was predicted, and their expression were verified when overexpressing hsa_circ_0006220 by RT-PCR.Hsa_circ_0006220 was found to be significantly downregulated in breast cancer tissues compared to the paired noncancerous tissues by microarray and RT-PCR. The expression of hsa_circ_0006220 was significantly inversely correlated with histological type (P=0.0028) and lymph node metastasis (P=0.0341). The area under the ROC curve (AUC) was 0.706. Five miRNAs that might be sponged by hsa_circ_0006220 were predicted. MiR-197-5p was significantly downregulated after overexpression of hsa_circ_0006220.Our results indicated that hsa_circ_0006220 may play a role in human breast cancer and might be a potential tumor marker for breast cancer screening." @default.
• W3132575616 created "2021-03-01" @default.
• W3132575616 creator A5009864563 @default.
• W3132575616 creator A5014979192 @default.
• W3132575616 creator A5058544003 @default.
• W3132575616 date "2021-02-01" @default.
• W3132575616 modified "2023-10-10" @default.
• W3132575616 title "Downregulation of hsa_circ_0006220 and its correlation with clinicopathological factors in human breast cancer" @default.
• W3132575616 cites W1032731786 @default.
• W3132575616 cites W1493361958 @default.
• W3132575616 cites W1754491478 @default.
• W3132575616 cites W182754908 @default.
• W3132575616 cites W1879429720 @default.
• W3132575616 cites W1968716940 @default.
• W3132575616 cites W1998477030 @default.
• W3132575616 cites W2004102690 @default.
• W3132575616 cites W2010461414 @default.
• W3132575616 cites W2017919052 @default.
• W3132575616 cites W2020475978 @default.
• W3132575616 cites W2034305079 @default.
• W3132575616 cites W2044702943 @default.
• W3132575616 cites W2048940716 @default.
• W3132575616 cites W2058835062 @default.
• W3132575616 cites W2064165694 @default.
• W3132575616 cites W2065846888 @default.
• W3132575616 cites W2081427413 @default.
• W3132575616 cites W2095799789 @default.
• W3132575616 cites W2121626677 @default.
• W3132575616 cites W2126938291 @default.
• W3132575616 cites W2132893003 @default.
• W3132575616 cites W2132940486 @default.
• W3132575616 cites W2137691989 @default.
• W3132575616 cites W2140963401 @default.
• W3132575616 cites W2153766359 @default.
• W3132575616 cites W2172167537 @default.
• W3132575616 cites W2209325576 @default.
• W3132575616 cites W2255059492 @default.
• W3132575616 cites W2279780945 @default.
• W3132575616 cites W2332619026 @default.
• W3132575616 cites W2346480860 @default.
• W3132575616 cites W2402967447 @default.
• W3132575616 cites W2421638364 @default.
• W3132575616 cites W2440841988 @default.
• W3132575616 cites W2466847990 @default.
• W3132575616 cites W2474303280 @default.
• W3132575616 cites W2606372789 @default.
• W3132575616 cites W2609210159 @default.
• W3132575616 cites W2776155300 @default.
• W3132575616 cites W2804009653 @default.
• W3132575616 cites W2811010093 @default.
• W3132575616 cites W2917423152 @default.
• W3132575616 cites W3010143586 @default.
• W3132575616 doi "https://doi.org/10.21037/gs-21-42" @default.
• W3132575616 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7944078" @default.
• W3132575616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33708563" @default.
• W3132575616 hasPublicationYear "2021" @default.
• W3132575616 type Work @default.
• W3132575616 sameAs 3132575616 @default.
• W3132575616 citedByCount "7" @default.
• W3132575616 countsByYear W31325756162021 @default.
• W3132575616 countsByYear W31325756162023 @default.
• W3132575616 crossrefType "journal-article" @default.
• W3132575616 hasAuthorship W3132575616A5009864563 @default.
• W3132575616 hasAuthorship W3132575616A5014979192 @default.
• W3132575616 hasAuthorship W3132575616A5058544003 @default.
• W3132575616 hasBestOaLocation W31325756161 @default.
• W3132575616 hasConcept C104317684 @default.
• W3132575616 hasConcept C121608353 @default.
• W3132575616 hasConcept C126322002 @default.
• W3132575616 hasConcept C127561419 @default.
• W3132575616 hasConcept C142724271 @default.
• W3132575616 hasConcept C145059251 @default.
• W3132575616 hasConcept C150194340 @default.
• W3132575616 hasConcept C153911025 @default.
• W3132575616 hasConcept C186836561 @default.
• W3132575616 hasConcept C2775893923 @default.
• W3132575616 hasConcept C2994423619 @default.
• W3132575616 hasConcept C48023723 @default.
• W3132575616 hasConcept C502942594 @default.
• W3132575616 hasConcept C530470458 @default.
• W3132575616 hasConcept C54355233 @default.
• W3132575616 hasConcept C58471807 @default.
• W3132575616 hasConcept C71924100 @default.
• W3132575616 hasConcept C86803240 @default.
• W3132575616 hasConceptScore W3132575616C104317684 @default.
• W3132575616 hasConceptScore W3132575616C121608353 @default.
• W3132575616 hasConceptScore W3132575616C126322002 @default.
• W3132575616 hasConceptScore W3132575616C127561419 @default.
• W3132575616 hasConceptScore W3132575616C142724271 @default.
• W3132575616 hasConceptScore W3132575616C145059251 @default.
• W3132575616 hasConceptScore W3132575616C150194340 @default.
• W3132575616 hasConceptScore W3132575616C153911025 @default.
• W3132575616 hasConceptScore W3132575616C186836561 @default.
• W3132575616 hasConceptScore W3132575616C2775893923 @default.
• W3132575616 hasConceptScore W3132575616C2994423619 @default.
• W3132575616 hasConceptScore W3132575616C48023723 @default.
• W3132575616 hasConceptScore W3132575616C502942594 @default.
• W3132575616 hasConceptScore W3132575616C530470458 @default.

• next